Coumarins — An Important Class of Phytochemicals

Matos, María João; Santana, Lourdes; Uriarte, Eugenio; Guirado, Orlando A. Abreu; Molina, Enrique; Yordi, Estela Guardado

doi:10.5772/59982

Cited by 152 publications

(149 citation statements)

References 96 publications

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“…More than 1300 coumarins have been identified as secondary metabolites from plants, bacteria, and fungi (Hwang et al 2013;Venugopala et al 2013;Wang et al 2013;Islam et al 2015). The name coumarin comes from a French term for the Tonka bean, coumarou (Dipteryx odorata), isolated by Vogel, 1820 (Venugopala et al 2013;Rohini and Srikumar 2014;Matos et al 2015). Due to its sweet odor, similar to vanilla, coumarin has been used in perfumes since 1882 (Aslam et al 2010;Santos et al 2013;Matos et al 2015).…”

Section: Introductionmentioning

confidence: 96%

“…The name coumarin comes from a French term for the Tonka bean, coumarou (Dipteryx odorata), isolated by Vogel, 1820 (Venugopala et al 2013;Rohini and Srikumar 2014;Matos et al 2015). Due to its sweet odor, similar to vanilla, coumarin has been used in perfumes since 1882 (Aslam et al 2010;Santos et al 2013;Matos et al 2015).…”

Section: Introductionmentioning

confidence: 96%

“…They were first synthesized in 1868, and it was used in the pharmaceutical industry as a precursor in the synthesis of a number of anticoagulant pharmaceuticals. The simplicity and versatility of the coumarin molecule makes it an interesting starting point for a wide range of applications (Matos et al 2015). They are used as technological potential in pharmaceutical, agrochemical, fragrance industries, food, cosmetic industry, and in color technology as optical brightening agents or laser dyes (Daru and Stirling 2011;Santos et al 2013;Venugopala et al 2013;Vekariya and Patel 2014).…”

Section: Introductionmentioning

confidence: 99%

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Fungi as a source of natural coumarins production

Costa

Tavares

Oliveira

2016

Appl Microbiol Biotechnol

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Natural coumarins and derivatives are compounds that occur naturally in several organisms (plant, bacteria, and fungi) consisting of fused benzene and α-pyrone rings. These compounds show high technological potential applications in agrochemical, food, pharmaceuticals, and cosmetics industries. Therefore, the need for bulk production of coumarins and the advancement of the chemical and pharmaceutical industries led to the development of synthetic coumarin. However, biotransformation process, synthetic bioengineering, metabolic engineering, and bioinformatics have proven effective in the production of natural products. Today, these biological systems are recognized as green chemistry innovation and business strategy. This review article aims to report the potential of fungi for synthesis of coumarin. These microorganisms are described as a source of natural products capable of synthesizing many bioactive metabolites. The features, classification, properties, and industrial applications of natural coumarins as well as new molecules obtained by basidiomycetes and ascomycetes fungi are reported in order to explore a topic not yet discussed in the scientific literature.

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Section: Introductionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Fungi as a source of natural coumarins production

Costa

Tavares

Oliveira

2016

Appl Microbiol Biotechnol

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“…Coumarins are mainly found in secondary plant metabolites, acting as growth regulators, controlling biochemical transformations and demonstrating defensive properties against infection (Chattha et al, 2018). They are also found in some bacteria, fungi or sponges and can be synthesized chemically (Matos et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Coumarins as potential supportive medication for the treatment of epilepsy

Bryda¹,

Zagaja²,

Szewczyk³

et al. 2019

Acta Neurobiologiae Experimentalis

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Epilepsy, one of the most common neurological disorders, is a chronic disease of the brain manifested by seizures due to sudden, spontaneous bioelectrical discharges in nerve cells. An estimated 50 million people worldwide suffer from epilepsy.Antiepileptic drugs are the mainstream treatment for epilepsy; however, the drug resistance occurring in 20-30% of patients and side effects of available medications have resulted in a search for natural remedies that can support disease therapy. Coumarins may be a promising option. They are a group of natural plant-derived substances of great interest due to their broad spectrum of biological activities, including potent pharmacological properties. Recent data from experimental models demonstrates the possibility for coumarin use as a supporting treatment of epileptic seizures. This article focuses on the most recent research reports available in the literature relating to the use of several selected coumarins in different experimental models of epilepsy.

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“…Moreover, these coumarin derivatives have been used essentially as coumarin‐based antioxidant, antineoplastic, anticancer, antidiabetic, antimicrobial, analgesic and anti‐neurodegenerative drugs . The use of coumarin‐supported chemosensors and fluorescent probes is rapidly becoming more popular as these have extensive application due to their specific pharmacokinetic and pharmacological properties in living cells …”

Section: Introductionmentioning

confidence: 99%

Bimolecular fluorescence quenching reactions of the biologically active coumarin composite 2‐acetyl‐3H‐benzo[f]chromen‐3‐one in different solvents

Koppal

Melavanki

Kusanur³

et al. 2018

Luminescence

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A study on fluorescence quenching was carried out for the coumarin derivative 2-acetyl-3H-benzo[f]chromen-3-one (2AHBC) with aniline at room temperature. Efficient fluorescence quenching was observed and Stern-Volmer (S-V) plots showed upward curves from linearity in all solvents of different polarities. For the solute 2AHBC, ground state complex formation does not hold in our study. The kinetic distance (r) value was found to be greater than the encounter distance (R) and indicated that the quenching reaction was held within the sphere of action. Diffusion-limited reactions were found to be more prominent in high polarity solvents, namely dimethyl sulfoxide (DMSO), DMF, ACN, methanol, ethanol, propanol and DCM. The relationships between quenching constant (K ) and dielectric constants (ε) of the different solvents were studied.

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Coumarins — An Important Class of Phytochemicals

Cited by 152 publications

References 96 publications

Fungi as a source of natural coumarins production

Fungi as a source of natural coumarins production

Coumarins as potential supportive medication for the treatment of epilepsy

Bimolecular fluorescence quenching reactions of the biologically active coumarin composite 2‐acetyl‐3H‐benzo[f]chromen‐3‐one in different solvents

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