Could the erythrocyte indices or serum ferritin predict the therapeutic response to a trial with oral iron during pregnancy? Results from the Accuracy study for Maternal Anaemia diagnosis (AMA)

Salvi, Cristiane Campello Bresani; Braga, Cynthia; Figueirôa, José Natal; Filho, Malaquias Batista

doi:10.1186/s12884-016-1005-x

Cited by 5 publications

(3 citation statements)

References 34 publications

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“…Although the MCH retains accuracy and stability between analysers and is somewhat less affected by pre‐analytical variables, it is not specific for iron deficiency. None of these parameters alone is able to predict response to oral iron 10–12 …”

Section: Haemoglobin Concentration and Red Cell Parameters (Hct MCV M...mentioning

confidence: 99%

Guideline for the laboratory diagnosis of iron deficiency in adults (excluding pregnancy) and children

et al. 2021

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This Good Practice Paper was compiled according to the British Society for Haematology (BSH) process at: https://b-s-h. org.uk/media/16732/bsh-guidance-development-process-dec-5-18.pdf. The BSH produces 'Good Practice Papers' to recommend good practice in areas where there is a limited evidence base but for which a degree of consensus or uniformity is likely to be beneficial to patient care. The Grading of Recommendations Assessment, Development and Evaluation (GRADE) nomenclature was used to evaluate levels of evidence and to assess the strength of recommendations. The GRADE criteria can be found at http://www.gradeworkinggroup.org. Literature review detailsUp to June 2020 MEDLINE and PUBMED were searched systematically for publications in English from 1966 to 2020, with additional ad hoc searches up to June 2021 for any new evidence using key words: iron deficiency, anaemia and each of the parameters discussed. Review of the manuscriptReview of the manuscript was performed by the BSH Guidelines Committee General Haematology Task Force, the BSH Guidelines Committee and the General Haematology sounding board of the BSH. It was made available on the members' section of the BSH website for comment.

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Section: Haemoglobin Concentration and Red Cell Parameters (Hct MCV M...mentioning

confidence: 99%

Guideline for the laboratory diagnosis of iron deficiency in adults (excluding pregnancy) and children

et al. 2021

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“…18.6% ± 5.3, P = 0.965) ( 16 ). Furthermore, RDW failed to predict responsiveness to iron supplementation therapy ( 17 , 18 ). De Sà et al studied RDW values in new-borns of anaemic and non-anaemic women.…”

Section: Discussionmentioning

confidence: 99%

Red blood cell distribution width in pregnancy: a systematic review

et al. 2018

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Anisocytosis has been associated with the severity and prognosis of several acute and chronic diseases, as well as physiological conditions such as pregnancy. Anisocytosis is quantified by the red blood cell distribution width (RDW), expressed as the ratio, multiplied by 100, between the standard deviation (SD) of red blood cell volumes and the mean corpuscular volume, or as the SD of erythrocyte volumes (RDW-SD). The aim of the present review was to report the state of the art on the physiological values and the putative diagnostic and prognostic roles of RDW in complicated pregnancy. Literature research for articles published in the last ten years was conducted in Pubmed, Web of Science, ClinicalTrials.gov, and Scopus databases. Abstracts were independently screened by two investigators. If relevant, full articles were retrieved. References, in these articles, citing relevant reviews or original studies were also accessed to identify additional eligible studies. Any disagreement between the reviewers was resolved by a third investigator. A total of 28 studies were included in the review. These studies reported changes in RDW values during physiological pregnancy, and associations between the RDW and several pregnancy complications including anaemia, preeclampsia, gestational diabetes, and recurrent miscarriage. This review provides background information for establishing physiological and pathological RDW values in pregnancy for diagnostic and prognostic use in clinical practice.

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“…Anemia in pregnancy is a major public health problem, especially in developing countries 1,2 . Different studies have shown different prevalence of anemia during pregnancy ranging from 16.6-95.0% [3][4][5][6] .…”

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confidence: 99%

Iron Deficiency Anemia by Serum Ferritin Levels at a Tertiary Care Hospital

2018

JMPB

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Background: Iron deficiency anemia (IDA) during pregnancy is a common nutritional disorder with adverse effects for the baby, such as premature birth and low birth weight, and the mother, such as cardiovascular symptoms and reduced physical and mental strength. Objective; To determine the frequency of iron deficiency anemia by serum ferritin levels at a tertiary care hospital. Material and Methods; All the patients who meet inclusion criteria of this study were registered from Department of Gynecology and Obstetrics, Nishtar Hospital Multan. Proper permission was taken from Institutional Ethical Committee to conduct this study. Examination was done including general physical examination. Venous blood sample (3 ml) was taken and sent to the Pathology Laboratory of the Hospital for serum ferritin levels estimation to diagnose iron deficiency anemia. Data was entered and analyzed by SPSS version 20. Results; Our study comprised of a total of 382 patients meeting inclusion criteria of our study. Mean gestational age of our study cases was 29.21 ± 7.16 weeks and 198 (51.8 %) had gestational age up to 30 weeks. Mean age of our study cases was 26.77 ± 4.29 years (with minimum age of our study cases was 20 years while maximum age was 36 years). Our study results have indicated that majority of our study cases i.e. 298 (78.0 %) were aged up to 30 years. Of these 382 study cases, 156 (40.8 %) belonged to rural areas and 226 (59.2 %) belonged to urban areas. Monthly family income up to Rs. 25000 was noted in 213 (55.8%) while more than Rs. 25000 was noted in 169 (44.2%). Of these 382 study cases, 241 (63.1%) were illiterate and 141 (36.9%) were literate. Mean duration of marriage was 5.17 ± 2.41 years and 199 (52.1%) had duration of marriage more than 5 years. Mean body mass index of our study cases was 25.82 ± 2.44 kg/m 2 and obesity was present in 56 (14.7 %) of our study cases. Mean serum Ferritin level was 11.43 ± 3.98 mg/dl and iron deficiency anemia was noted in 213 (55.8%) of our study cases. Conclusion; Very high frequency of iron deficiency anemia was noted in our study among pregnant women. Iron Deficiency anemia was significantly associated with gestational age, age, residential status, low family income and duration of marriage. All the clinicians should screen these pregnant ladies for serum ferritin levels at the start of pregnancy and should counsel them for better awareness which will lead to proper management of iron deficiency anemia.

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Could the erythrocyte indices or serum ferritin predict the therapeutic response to a trial with oral iron during pregnancy? Results from the Accuracy study for Maternal Anaemia diagnosis (AMA)

Cited by 5 publications

References 34 publications

Guideline for the laboratory diagnosis of iron deficiency in adults (excluding pregnancy) and children

Guideline for the laboratory diagnosis of iron deficiency in adults (excluding pregnancy) and children

Red blood cell distribution width in pregnancy: a systematic review

Iron Deficiency Anemia by Serum Ferritin Levels at a Tertiary Care Hospital

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