Cost-effectiveness of Screening for Colorectal Cancer in the General Population

Abstract

Screening for CRC, even in the setting of imperfect compliance, significantly reduces CRC mortality at costs comparable to other cancer screening procedures. However, compliance rates significantly affect the incremental CE ratios. In this model of CRC, 60% compliance with an every 5-year schedule of screening was roughly equivalent to 100% compliance with an every 10-year schedule. Mathematical modeling used to inform clinical guidelines needs to take into account expected compliance rates. JAMA. 2000;284:1954-1961.

Survival and costs of colorectal cancer treatment and effects of changing treatment strategies: a model approach

“…Norwegian study by Aas [10], our overall cost estimate was 39% higher, but only 1.3% higher after adjusting for differences in the included costs and time horizon (see more in [5]). The increase in costs according to the disease stage was similar to increases reported by Ladabaum et al [23] and Frazier et al [21], while Brown et al [24] found an increase in costs for stages I-III, but a decrease for stages IV.…”

Cost‐effectiveness analysis of a community‐based colorectal cancer screening program in Shanghai, China

“…We also found that the cost of colonoscopy and pathology had a limited influence on ICER, which is consistent with the results of a previous study 44 . The cost of colonoscopy during screening therefore might contribute little to the incremental costs.…”

Comparison of various strategies for colorectal cancer screening tests

“…For this reason, we used the transition probabilities for determination of the initial probability distribution. The determined values lie within the ranges published in [1].…”