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“…The primary driver of the reduced cost of medical care for patients treated with the TSA-based outpatient protocol was reduced cost of hospitalization. Our total cost data at 6 months are similar to that estimated by Seaman et al 16 using a Markov analysis applied to data from the EINSTEIN trial, and the cost difference is similar to that estimated by Lefebvre et al 17 We found 6-month total costs to be $1,446 for rivaroxaban versus $4,006 for LMWH-warfarin for a sample with a mean age of 50 years. The Markov model estimated costs of Seaman et al 16 at $3,195 for rivaroxaban versus $6,188 for LMWH-warfarin for a male of 60 years of age treated for 3 to 12 months.…”
Section: Discussionsupporting
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“…The primary driver of the reduced cost of medical care for patients treated with the TSA-based outpatient protocol was reduced cost of hospitalization. Our total cost data at 6 months are similar to that estimated by Seaman et al 16 using a Markov analysis applied to data from the EINSTEIN trial, and the cost difference is similar to that estimated by Lefebvre et al 17 We found 6-month total costs to be $1,446 for rivaroxaban versus $4,006 for LMWH-warfarin for a sample with a mean age of 50 years. The Markov model estimated costs of Seaman et al 16 at $3,195 for rivaroxaban versus $6,188 for LMWH-warfarin for a male of 60 years of age treated for 3 to 12 months.…”
Section: Discussionsupporting
“…60,61,232 One industry-sponsored cost-effectiveness model comparing rivaroxaban to LMWH and a VKA, based on the EINSTEIN trial, 204,215,216 concluded that there was a high probability that rivaroxaban was cost-effective. 233 We also found that rivaroxaban was likely to be cost-effective for primary prevention after TKR and THR. However, despite including a larger number of trials in a NMA than previous cost-effectiveness models, our interpretation is tentative because of imprecise estimates about effect and safety.…”
Section: Comparisons With the Literaturementioning
“…Rivaroxaban was cost-effective compared to warfarin in three different Markov models using different model time frame from the perspective of U.S. health-care system. [16][17][18] Dabigatran was found to be costsaving or cost-effective compared to vitamin K antagonists for the treatment of DVT in an analysis based on INR monitoring cost data from a Dutch hospital. [33] Lifetime treatment of apixaban was shown to be cost-effective compared to rivaroxaban, dabigatran and low molecular weight heparin/Vitamin-K antagonist in a Markov model performed from UK cost perspective.…”
Section: Discussionmentioning
“…Estimates for post-ICH cost ($2764) were obtained from the literature. [18,24] The two evaluated treatment options in the model were the following: (1) edoxaban (60 mg once daily) with a 5-day heparin lead-in (enoxaparin 80 mg/0.8 mL twice daily, based on the dosing of 1 mg/kg body weight and assumed 80 kg body weight) [18]; and(2) warfarin (5 mg once daily) with a 5-day heparin bridge (enoxaparin 80 mg/0.8 mL twice daily). Unit costs for edoxaban ($9.24 per day) and warfarin ($0.36 per day) were based on the wholesale acquisition cost as of January 2015.…”
Section: Resource Utilization and Cost Estimatesmentioning
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