Cost and Characteristics of Intravenous Proton Pump Inhibitor Use and Misuse in a Tertiary Care Hospital

Correlates and economic outcomes of proton pump inhibitor use by routes in intensive care unit patients

“…Though parenteral PPI administration may be appropriate in some cases, the inappropriate and costly use of intravenous (i.v.) PPIs as reported in the literature [16][17][18] can be avoided. Consequently, many studies encourage the use of oral versus i.v.…”

“…Therefore, 'treatment algorithms or protocols for SUP based on prescribing patterns, hospital formulary restrictions, and cost-analysis are needed for each institution to guide critical care providers on the appropriate delivery of SUP treatments' [13,14]. Despite several potential advantages of oral administration of PPI into the gastrointestinal tract, physicians and pharmacists often choose the parenteral route for PPI administration over the enteral route [15][16][17][18]. Though parenteral PPI administration may be appropriate in some cases, the inappropriate and costly use of intravenous (i.v.)…”