Cosmetic Dermatology

Glogau, Richard G.

doi:10.1001/archderm.134.10.1204

Cited by 11 publications

(6 citation statements)

References 2 publications

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“…Besides clinically visible AKs, it is well known that subclinical lesions can also be detected in chronically sun‐exposed skin which is described by the concept of field cancerisation . The risk of progression into invasive cutaneous squamous cell carcinoma (SCC) of a single AK ranges between 0.025% and 16% per year . Accordingly, the risk of developing an SCC rises with increasing numbers of AK lesions .…”

Section: Introductionmentioning

confidence: 99%

“…The risk of progression into invasive cutaneous squamous cell carcinoma (SCC) of a single AK ranges between 0.025% and 16% per year . Accordingly, the risk of developing an SCC rises with increasing numbers of AK lesions . Since it is not possible to predict if and when an AK will transform into invasive SCC, treatment is advised to prevent tumour progression .…”

Section: Introductionmentioning

confidence: 99%

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Argon plasma coagulation of actinic keratoses imaged by optical coherence tomography: An in vivo study indicating a possible lesion‐directed treatment

Schmitz

Hessam

Scholl

et al. 2018

Journal of Biophotonics

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Actinic keratoses (AKs) can progress into invasive squamous cell carcinoma and thus may become a life threatening disease. Argon plasma coagulation (APC) might complement the therapeutic armamentarium in particular for AK lesions. However, there is no data on APC-induced micromorphological changes following the treatment of AKs. We aimed to determine in vivo APC-induced effects on the epidermis and dermoepidermal junction (DEJ) zone in AK lesions. We performed APC in 108 AKs using the spray mode with a power setting of 15 W and a flow rate of 2.0 L/min. Before and after the intervention, optical coherence tomography (OCT) was performed. After APC, 74.2% (46/62) lesions presented with clearly demarcated DEJ and without any epidermal tissue left, 25.8% (16/62) of treated lesions showed residual epidermal tissue left. In 19.4% (12/62), parts of the DEJ and in 6.5% (4/62), the entire DEJ could not be discriminated. The χ test showed a significant (P = 0.0025) association between the presence of hyperkeratosis prior to APC and intact DEJ after APC. In conclusion, APC as shown by OCT is a well controllable treatment modality for AKs causing only limited damage to dermal tissue. Further studies are needed to evaluate clinical outcome as well as recurrence rates.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Argon plasma coagulation of actinic keratoses imaged by optical coherence tomography: An in vivo study indicating a possible lesion‐directed treatment

Schmitz

Hessam

Scholl

et al. 2018

Journal of Biophotonics

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“…Actinic keratoses (AKs) are common skin disorders, predominantly found in sun exposed surfaces . AKs are premalignant intra‐epithelial lesions (PELs) that can progress to squamous cell carcinomas (SCCs) . An example of an intra‐epithelial SCC is Bowen's diseases (BDs).…”

Section: Introductionmentioning

confidence: 99%

Focal adhesion kinase and Src expression in premalignant and malignant skin lesions

Choi

Kim

Sohn

et al. 2015

Experimental Dermatology

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Focal adhesion kinase (FAK) and Src are non-receptor tyrosine kinases. FAK and Src play a critical role in inducing malignant transformation in tumor cells. We performed immunohistochemical staining for total and phosphorylated forms of FAK and Src, to evaluate the role of FAK and Src in the development of premalignant and malignant skin lesions. A total of 59 facial skin samples (30 actinic keratoses, 10 Bowen's diseases, 13 squamous cell carcinomas and six perilesional skins) were immunohistochemically stained for Ki-67, total (t) and phosphorylated (p) form of FAK and Src. Cells positive for t-Src, p-Src-y530, t-FAK and pFAK-s722 were detected in premalignant intra-epithelial lesions (PELs) and squamous cell carcinomas (SCCs), but not in the perilesional skin. There was a tendency towards high correlation between Ki-67 and t-FAK or pFAK-s722, suggestive of the active role of FAK in cell proliferation. However, our findings of higher t-Src and p-Src-y530 positive cells in PELs, as compared to SCCs (with higher Ki-67 level), are suggestive of the other role of Src in tumor formation and progression, which requires further investigation.

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“…Skin is the first line of defense to various adverse conditions, such as rashes, burns, injuries, infections, and disorders, such as scleroderma, dermatitis, psoriasis, and cancer [11,12]. The skin's morphological change that comes with aging is wrinkles, decrease the number of sweat glands and blood vessels, dryness, develop brown spots, heliodermatitis and hyperplasia of elastic fibres [13][14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Anti-aging Effect of Free Curcumin and Niosome Entrapping Curcumin in H2O2-induced Aging in Human Fibroblast Cell Lines

Mohammad¹

2019

JAP

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Aging is not a disease but it a changes that come with time, aging may make an individual susceptible to disease. Exposure to smoke, UV radiation, chemicals or other exogenous agents over time can damage cells, as can produce DNA replication errors or oxidative stress. The use of antioxidant curcumin can produce intracellular defenses in addition to low expensive and no side effect. In the present study, hydrogen peroxide (H2O2) was used to produce oxidative stress in Human Fibroblast cell lines (HFB4) and free curcumin and niosome entrapping curcumin treatments are used for aged HFB4 cell lines. Using Flowcytometry analysis, p 16 INK4a and p53 BP1 genes levels were investigated as aging biomarkers. Result show that H2O2 treated cell lines are highly elevate p16 INK4a and p53 BP1 genes. While HFB4 cells treated with free curcumin and niosome entrapping curcumin were significantly protected against aged process.

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Cosmetic Dermatology

Cited by 11 publications

References 2 publications

Argon plasma coagulation of actinic keratoses imaged by optical coherence tomography: An in vivo study indicating a possible lesion‐directed treatment

Argon plasma coagulation of actinic keratoses imaged by optical coherence tomography: An in vivo study indicating a possible lesion‐directed treatment

Focal adhesion kinase and Src expression in premalignant and malignant skin lesions

Anti-aging Effect of Free Curcumin and Niosome Entrapping Curcumin in H2O2-induced Aging in Human Fibroblast Cell Lines

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