Cosmeceuticals. A proposal for rational definition, evaluation, and regulation

Vermeer, Bert-Jan

doi:10.1001/archderm.132.3.337

Cited by 23 publications

(14 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Retinol products are over-the-counter alternatives to topical antiageing treatments; however, retinoic acid is not used for topical application because it is registered as a drug, as is the case with synthetic retinoids such as adapalene, tazarotene, and bexarotene. In contrast, retinyl esters, retinol, retinaldehyde, and the oxoretinoids can be used in topical cosmeceutical preparations [1][2][3].…”

Section: Introductionmentioning

confidence: 99%

A Clinical Anti-Ageing Comparative Study of 0.3 and 0.5% Retinol Serums: A Clinically Controlled Trial

Zasada

Budzisz

Erkiert‐Polguj

2020

Skin Pharmacol Physiol

View full text Add to dashboard Cite

Background: Retinol influences the process of keratinization of the epidermis, which improves stratum corneum structure and reduces transepidermal water loss. It also significantly enhances mature skin by brightening hyperpigmentation and reducing the signs of photoageing. Cosmeceuticals are intended to both provide aesthetic effects for the skin and allow dermatological treatment. The aim of the study was to assess the rejuvenating effect of retinol serum on facial skin at concentrations of 0.3 and 0.5%, as well as any improvements in skin brightening and elasticity. Materials and Methods: Thirty-seven volunteers were included in the study, after confirming tolerance. The novel formula was applied once daily to the face for a period of 12 weeks: one retinol concentration on the left side and the other on the right. The initial study with liquid crystal formula (study vehicle) was carried out for 8 weeks on 28 volunteers. Treatment efficiency was evaluated at baseline, and 56 and 84 days following treatment using the multi probe adapter and Fotomedicus imaging system. PRIMOS was used to measure skin surface roughness. The visual analogue scale method enabled the results to be determined by 3 independent specialists. Results: Skin hyperpigmentation, unevenness, and wrinkles gradually decreased over the course of treatment, both on the left and right parts of the face. Adverse events were predominantly mild or moderate skin irritation. More frequent and more intense symptoms were observed on the left side (0.5%). Conclusion: Retinol in liquid crystal formulation is safe and provides significant clinical benefits associated with unification of skin colour, overall skin tone, skin elasticity, and moisture. Regular use of retinol typically results in brightening of the skin and reduced signs of ageing. The objective findings confirmed the effectiveness of the procedures. © 2020 S. Karger AG, Basel Enrollment Assessed for eligibility (n = 71) Excluded (n = 4) ♦ Not meeting inclusion criteria (n = 4) ♦ Declined to participate (n = 0) ♦ Other reasons (n = 0) Allocated to intervention (n = 28) ♦ Received allocated intervention (n = 28) ♦ Did not receive allocated intervention (give reasons) (n = 0) Lost to follow-up (n = 0) Discontinued intervention (n = 0) Analysed (n = 28) ♦ Excluded from analysis (give reasons) (n = 0) Allocated to intervention (n = 39) ♦ Received allocated intervention (n = 39) ♦ Did not receive allocated intervention (give reasons) (n = 0) Analysed (n = 37) ♦ Excluded from analysis (give reasons) (n = 0) Lost to follow-up due to private matters (n = 2) Discontinued intervention (n = 0) Randomized (n = 67) Allocation Follow-up Analysis Fig. 1. Transparent reporting of 12-week trials.

show abstract

Section: Introductionmentioning

confidence: 99%

A Clinical Anti-Ageing Comparative Study of 0.3 and 0.5% Retinol Serums: A Clinically Controlled Trial

Zasada

Budzisz

Erkiert‐Polguj

2020

Skin Pharmacol Physiol

View full text Add to dashboard Cite

show abstract

“…Cosmeceutical formulations must be tested for 3 important reasons: (1) to determine that they provide a benefit that is perceived by the consumer; (2) to establish that the formulation is safe and free of adverse reactions; and (3) to support marketing claims. Consumers purchase a new cosmeceutical once based on the name, promises made on the packaging, recommendations from advertising or acquaintances, appearance, and fragrance.…”

Section: Development Of Scientific Substantiationmentioning

confidence: 99%

Cosmeceuticals

Draelos

2014

Dermatologic Clinics

View full text Add to dashboard Cite

“…Regulatory texts concerning the definitions of drugs and cosmetics can be found in recent reviews. 3,4 Food and dietary regulations must also be considered as a part of public health safety requirements. It is beyond the scope of this article to repeat administrative definitions, and indeed these may vary from country to country.…”

Section: Regulation Of Drugs and Cosmeticsmentioning

confidence: 99%

The field of cosmetic dermatology: the need for a patient‐centred approach

Wallach¹

2002

J of Cosmetic Dermatology

View full text Add to dashboard Cite

Similar of knowledge and skills are required to deal with certain skin disorders and their corresponding cosmetic complaints. The field of cosmetic dermatology is growing as an overlap between the medical treatment of skin diseases and traditional cosmetology. This poses problems for dermatologists and other professionals, including regulation agencies. Dermatology should be able patients to benefit from all that is necessary for their care, whether that be surgery, drugs or cosmetics. There is no need to modify current regulations. A patient-orientated approach is advocated.

show abstract

Cosmeceuticals. A proposal for rational definition, evaluation, and regulation

Cited by 23 publications

References 10 publications

A Clinical Anti-Ageing Comparative Study of 0.3 and 0.5% Retinol Serums: A Clinically Controlled Trial

A Clinical Anti-Ageing Comparative Study of 0.3 and 0.5% Retinol Serums: A Clinically Controlled Trial

Cosmeceuticals

The field of cosmetic dermatology: the need for a patient‐centred approach

Contact Info

Product

Resources

About