Cortisol and dehydroepiandrosterone sulfate in patients with schizophrenia spectrum disorders with respect to cognitive performance

Misiak, Błażej; Piotrowski, Patryk; Chęć, Magdalena; Samochowiec, Jerzy

doi:10.1016/j.cpnec.2021.100041

Cited by 6 publications

(8 citation statements)

References 46 publications

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“…controls. This is in agreement with the results of most studies [2,[12][13][18][19][20][21][22][23][24][25][26][27]. However, there are studies reporting no significant differences between the schizophrenic patients and healthy controls in terms of serum cortisol levels [16,[28][29] as well as lower serum cortisol levels in patients with schizophrenia [30][31].…”

Section: Discussionsupporting

confidence: 91%

“…Examined serum DHEA-S levels in this study showed statistically significant higher levels in patients with schizophrenia compared to control subjects, which coincided with the results of most studies [15,19,21,28,[33][34][35][36]. By contrast, some other studies found decreased serum DHEA-S levels [37] and no difference [2,16] in schizophrenia patients compared to healthy controls.…”

Section: Discussionsupporting

confidence: 90%

“…Finally, we found that the cortisol/DHEA-S ratio was not significantly different between patients with schizophrenia and control group, but it significantly decreased over the 6 week period of treatment with the different types of antipsychotics (typical/atypical). Previous research suggests that the ratio of cortisol/DHEA-S may be increased in patients with schizophrenia [16], however some studies found no difference in ratio compared to healthy controls [2,23] and the authors of a recent study report a significant decrease of cortisol/DHEA-S ratio in patients relative to controls [36]. We also found no significant difference in cortisol/DHEA-S ratio between the subgroup of patients treated with typical antipsychotics and the subgroup treated with atypical antipsychotics.…”

Section: Discussionmentioning

confidence: 92%

“…Schizophrenia is a chronic and disabling mental disorder characterized by psychopathological symptoms, elevated emotional distress and a significant decline in cognition, quality of life and psychosocial functioning [1]. Apart from a clear role of genetic factors, a number of environmental exposure factors have been identified that increase a risk of schizophrenia [2]. For instance, it has been reported that stressful life events at various life periods play an important role in shaping the risk for schizophrenia and triggering psychotic relapse [3].…”

Section: Correlation Between the Different Types Of Antipsychotics An...mentioning

confidence: 99%

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Correlation Between the Different Types of Antipsychotics and Serum Cortisol, Dehidroepiandrosterone Sulfat and their Ratio in Schizophrenia

Babinkostova

Manuseva

Marković

2022

Prilozi

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Background: Evidence for disturbances in HPA activation and abnormal HPA regulatory mechanisms in schizophrenia is accumulating. Aim: To compare serum levels of cortisol, DHEA-S and their ratio between patients with schizophrenia and healthy controls and among patients before and after treatment with different types of antipsychotics. Material and methods: In this clinical prospective study, 60 patients with schizophrenia and 40 healthy age and sex matched control subjects were included. All patients experienced an acute exacerbation of the illness (PANSS: P1 and P3 ≥ 4). Clinical evaluation of patients was performed using the Positive and Negative Symptom Scale. A questionnaire for socio-demographic and clinical data collection was used. Serum levels of cortisol, DHEA-S and their ratio were measured at baseline in all participants and after 3 and 6 weeks, respectively, of the antipsychotic treatment with different types of antipsychotics in patients with schizophrenia. Results: Patients with schizophrenia had significantly higher serum cortisol and DHEA-S levels in comparison to the control group. There was no significant difference in serum levels of cortisol, DHEA-S and their ratio between patients treated with different types of antipsychotics (typical/atypical). Serum levels of the analyzed hormones significantly reduce during the 6-week period of examination in both subgroups treated with different types of antipsychotics. Conclusion: Elevated serum cortisol and DHEA-S in schizophrenic patients might be associated with their role in the pathophysiology of the disorder. There is no significant difference in serum levels of cortisol, DHEA-S and their ratio among the patients treated with different types of antipsychotics.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 92%

Section: Correlation Between the Different Types Of Antipsychotics An...mentioning

confidence: 99%

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Correlation Between the Different Types of Antipsychotics and Serum Cortisol, Dehidroepiandrosterone Sulfat and their Ratio in Schizophrenia

Babinkostova

Manuseva

Marković

2022

Prilozi

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“…Moreover, there is evidence that ACEs might contribute to dysfunction of the HPA axis in psychosis ( 38 – 41 ). Our group has recently reported that elevated cortisol levels might be associated with deficits of delayed memory in subjects with SSD ( 42 ). In turn, Aas et al ( 40 ) found that elevated hair cortisol levels are correlated with working memory deficits in individuals with schizophrenia and bipolar disorder.…”

Section: Discussionmentioning

confidence: 99%

Adverse Childhood Experiences and Neurocognition in Schizophrenia Spectrum Disorders: Age at First Exposure and Multiplicity Matter

et al. 2021

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Adverse childhood experiences (ACEs) might be related to cognitive impairments observed in schizophrenia spectrum disorders (SSD). However, it remains unknown what aspects of ACEs are associated with cognitive impairments in SSD. Therefore, we aimed to investigate the association between various characteristics of ACEs (age at first exposure, severity, and multiplicity) and cognition in SSD and healthy controls (HCs). We enrolled 127 individuals with SSD and 56 HCs. Cognitive performance was assessed using the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). The Childhood Experience of Care and Abuse Questionnaire was administered to record a history of ACEs. The following characteristics of ACEs were analyzed: multiplicity, severity, and age at first exposure. Individuals with SSD had significantly lower scores on all RBANS domains. Multiplicity and severity of ACEs were significantly higher in patients with SSD compared to HCs. In both groups, greater multiplicity of ACEs was associated with lower scores of global cognition and delayed memory. Additionally, in subjects with SSD, greater multiplicity and younger age at first exposure were associated with lower scores of attention. The present findings indicate that greater multiplicity and younger age at first exposure are the most important aspects of ACEs contributing to cognitive impairments observed in SSD. Moreover, ACEs might exert differential impact on cognition in SSD and HCs.

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Blood concentrations of anterior pituitary hormones in drug-naïve people with first-episode psychosis: A systematic review and meta-analysis

Cavaleri,

Capogrosso,

Guzzi

et al. 2023

Psychoneuroendocrinology

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Cortisol and dehydroepiandrosterone sulfate in patients with schizophrenia spectrum disorders with respect to cognitive performance

Cited by 6 publications

References 46 publications

Correlation Between the Different Types of Antipsychotics and Serum Cortisol, Dehidroepiandrosterone Sulfat and their Ratio in Schizophrenia

Correlation Between the Different Types of Antipsychotics and Serum Cortisol, Dehidroepiandrosterone Sulfat and their Ratio in Schizophrenia

Adverse Childhood Experiences and Neurocognition in Schizophrenia Spectrum Disorders: Age at First Exposure and Multiplicity Matter

Blood concentrations of anterior pituitary hormones in drug-naïve people with first-episode psychosis: A systematic review and meta-analysis

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