Corticotropin releasing factor and neuroplasticity in cocaine addiction

Corominas, M.; Roncero, Carlos; Casas, Miguel

doi:10.1016/j.lfs.2009.11.005

Cited by 31 publications

(48 citation statements)

References 126 publications

(154 reference statements)

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“…In addition, this system has been recently shown to be responsible for the anxiolytic effects of EE (Sztainberg et al, 2010) and in the stress-induced increases in cocaine CPP (Kreibich et al, 2009), suggesting that it may also be involved in the behavioral consequences of environmental switch. In addition, CRF has been shown to have major roles in drug-taking and drug-seeking behavior (Corominas et al, 2010;Koob, 2008), and in models of relapse (Buffalari et al, 2011;Shalev et al, 2010). In agreement with this role, we found that switch from EE to SE produces significant increases in CRF mRNA levels in the BNST, a brain region critically involved in stress responses and emotions (Davis and Whalen, 2001).…”

Section: Discussionsupporting

confidence: 80%

Erratum: Loss of Environmental Enrichment Increases Vulnerability to Cocaine Addiction

Nader¹,

Chauvet²,

Rawas³

et al. 2014

Neuropsychopharmacol

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Life experiences, especially during critical periods of maturation, such as adolescence, can dramatically affect vulnerability to diseases at adulthood. Early exposure to positive environmental conditions such as environmental enrichment (EE) has been shown to reduce the occurrence and the intensity of neurological and psychiatric disorders including drug addiction. However, whether or not exposure to EE during early stages of life would protect from addiction when, at adulthood, individuals may find themselves in non-enriched conditions has not been investigated. Here we show that switching mice from EE to non-enriched standard environments not only results in the loss of the preventive effects of EE but also increases the rewarding effects of cocaine. This enhanced vulnerability is associated with emotional distress and with increased levels in the mRNA levels of corticotropin releasing factor (CRF) in the bed nucleus of the stria terminalis (BNST), as well as with increases in CREB phosphorylation in the BNST and in the shell of the nucleus accumbens. The increased sensitivity to the rewarding effects of cocaine is completely blocked by the CRF antagonist antalarmin, confirming a major role of the CRF system in the negative consequences of this environmental switch. These results indicate that positive life conditions during early stages of life, if they are not maintained at adulthood, may have negative emotional consequences and increase the risks to develop drug addiction.

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Section: Discussionsupporting

confidence: 80%

Erratum: Loss of Environmental Enrichment Increases Vulnerability to Cocaine Addiction

Nader¹,

Chauvet²,

Rawas³

et al. 2014

Neuropsychopharmacol

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“…Psychogenic and environmental stressors are thought to converge on common stress-responsive brain structures, including the paraventricular nucleus (Pacak, Palkovits et al 1995; Sawchenko, Brown et al 1996; Herman, Flak et al 2008). In fact, activation of the hypothalamic-pituitary-adrenal (HPA) axis, and in particular corticotropin releasing factor (CRF) (Corominas, Roncero et al 2010), is implicated in behavioral sensitization to cocaine (Motheral, Cox et al 2002). …”

Section: Discussionmentioning

confidence: 99%

“…The role of CRF in cocaine addiction is well-established (Corominas, Roncero et al 2010). CRF binding protein and the type 2 CRF receptor play key roles in cocaine-seeking behavior (Wang, You et al 2007).…”

Section: Discussionmentioning

confidence: 99%

Cocaine Use in the Past Year Is Associated With Altitude of Residence

Fiedler

Kim

Kondo

et al. 2012

Journal of Addiction Medicine

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Objectives Recently, increased rates of suicide in counties at higher altitudes have been noted. Due to the documented association between cocaine use and suicide, we hypothesized that there would be a correlation between incidence of cocaine use and altitude of residence. Methods Cocaine use data was obtained from the Substate Substance Abuse Estimates from the 1999-2001 National Surveys on Drug Use and Health. Data related to the percentages of people 12 years or older who used cocaine in the past year. Average elevation for United States counties was calculating using the Shuttle Radar Topography Mission elevation dataset and subject region elevation was calculated by averaging the weighted elevations of each region's relevant counties. The correlation between elevation of a substate region and cocaine use in that region was calculated using Pearson correlation coefficients. Results A significant correlation exists between mean altitude of a substate region and cocaine use in that region (r=0.34; p < 0.0001). Regression analysis controlling for age, gender, race, education level, income, unemployment, and population density was performed. Altitude remained a significant factor (p = 0.007), while male sex (p = 0.008) and possessing less than a college education (p < 0.0001) were also significant predictors of self-reported cocaine use in the past year. It is important to note that cocaine use was assessed in isolation of other drugs of abuse, an additional confounding variable. Conclusions This study demonstrates a significant correlation between altitude of substate region of residence and cocaine use. It is possible that stress response due to hypoxia is responsible, however, this requires further investigation. However, because other substance use was not assessed, specificity of this association is unknown Additionally, this correlation may help to explain the elevated rate of suicide in areas of higher elevation.

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“…Addictive drugs not only influence the function of the mesolimbic dopamine system [33] they also trigger a variety of between-systems anatomical [57][58][59][60][61][62] and functional neuroadaptations [63][64][65][66] as well as changes in gene transcription and function in a number of brain systems including the hypothalamus [67], the VTA [68], the amygdala [69][70][71][72][73][74], Acb [75][76][77][78][79], dorsal striatum [80], orbital [81][82] and prefrontal cortices [83][84][85], with important effects on stress responsivity [86][87][88] and epigenetic processes in the limbic system [77;89-92].…”

Section: Drug Self-administration Modelsmentioning

confidence: 99%