Corticosteroids for treating severe sepsis and septic shock

Comparative effect sizes in randomised trials from less developed and more developed countries: meta-epidemiological assessment

“…Antenatal corticosteroids 33 noticeably reduced fetal and neonatal deaths when given to women at risk of preterm birth in trials conducted in less developed countries, but had a modest, non-nominally significant benefit in trials conducted in more developed countries ( fig 1⇓). A similar pattern was observed for corticosteroids in the treatment of sepsis or septic shock ( fig 2⇓), 34 42 tended to increase mortality in trials from more developed countries and decrease mortality in trials from less developed countries. Finally, altered fractionation radiotherapy compared with conventional radiotherapy resulted in nominally significant decreases in total mortality from oral cavity and oropharyngeal cancer in both less and more developed countries, although this was larger in trials from less developed countries ( fig 11⇓).…”

Comparative effect sizes in randomised trials from less developed and more developed countries: meta-epidemiological assessment

“…Antenatal corticosteroids 33 noticeably reduced fetal and neonatal deaths when given to women at risk of preterm birth in trials conducted in less developed countries, but had a modest, non-nominally significant benefit in trials conducted in more developed countries ( fig 1⇓). A similar pattern was observed for corticosteroids in the treatment of sepsis or septic shock ( fig 2⇓), 34 42 tended to increase mortality in trials from more developed countries and decrease mortality in trials from less developed countries. Finally, altered fractionation radiotherapy compared with conventional radiotherapy resulted in nominally significant decreases in total mortality from oral cavity and oropharyngeal cancer in both less and more developed countries, although this was larger in trials from less developed countries ( fig 11⇓).…”

Regulation of renal glucose transporters during severe inflammation

“…Because of overlapping actions of different proinflammatory cytokines, the regulation of glucose transporters cannot be attributed to single cytokines, providing an explanation why single anti-cytokine strategies do not improve the outcome of septic patients. In addition, our findings contribute to an explanation and understanding of the beneficial effects of glucocorticoids in septic patients (1,2,5,24).…”

Regulation of Renal Sodium Transporters during Severe Inflammation

“…Because of overlapping actions of different proinflammatory cytokines, downregulation of sodium transporters cannot be attributed to single cytokines, providing an explanation for why anti-singlecytokine strategies did not improve the outcome of patients with sepsis (37)(38)(39). In addition, our findings contribute to the explanation and understanding of the beneficial effects of glucocorticoids on the outcome of patients with sepsis (52)(53)(54)(55).…”

Comparative effect sizes in randomised trials from less developed and more developed countries: meta-epidemiological assessment

“…Antenatal corticosteroids 33 noticeably reduced fetal and neonatal deaths when given to women at risk of preterm birth in trials conducted in less developed countries, but had a modest, non-nominally significant benefit in trials conducted in more developed countries ( fig 1⇓). A similar pattern was observed for corticosteroids in the treatment of sepsis or septic shock ( fig 2⇓), 34 42 tended to increase mortality in trials from more developed countries and decrease mortality in trials from less developed countries. Finally, altered fractionation radiotherapy compared with conventional radiotherapy resulted in nominally significant decreases in total mortality from oral cavity and oropharyngeal cancer in both less and more developed countries, although this was larger in trials from less developed countries ( fig 11⇓).…”

Regulation of renal glucose transporters during severe inflammation

“…Because of overlapping actions of different proinflammatory cytokines, the regulation of glucose transporters cannot be attributed to single cytokines, providing an explanation why single anti-cytokine strategies do not improve the outcome of septic patients. In addition, our findings contribute to an explanation and understanding of the beneficial effects of glucocorticoids in septic patients (1,2,5,24).…”

Regulation of Renal Sodium Transporters during Severe Inflammation

“…Because of overlapping actions of different proinflammatory cytokines, downregulation of sodium transporters cannot be attributed to single cytokines, providing an explanation for why anti-singlecytokine strategies did not improve the outcome of patients with sepsis (37)(38)(39). In addition, our findings contribute to the explanation and understanding of the beneficial effects of glucocorticoids on the outcome of patients with sepsis (52)(53)(54)(55).…”

Comparative effect sizes in randomised trials from less developed and more developed countries: meta-epidemiological assessment

“…Antenatal corticosteroids 33 noticeably reduced fetal and neonatal deaths when given to women at risk of preterm birth in trials conducted in less developed countries, but had a modest, non-nominally significant benefit in trials conducted in more developed countries ( fig 1⇓). A similar pattern was observed for corticosteroids in the treatment of sepsis or septic shock ( fig 2⇓), 34 42 tended to increase mortality in trials from more developed countries and decrease mortality in trials from less developed countries. Finally, altered fractionation radiotherapy compared with conventional radiotherapy resulted in nominally significant decreases in total mortality from oral cavity and oropharyngeal cancer in both less and more developed countries, although this was larger in trials from less developed countries ( fig 11⇓).…”

Regulation of renal glucose transporters during severe inflammation

“…Because of overlapping actions of different proinflammatory cytokines, the regulation of glucose transporters cannot be attributed to single cytokines, providing an explanation why single anti-cytokine strategies do not improve the outcome of septic patients. In addition, our findings contribute to an explanation and understanding of the beneficial effects of glucocorticoids in septic patients (1,2,5,24).…”

Regulation of Renal Sodium Transporters during Severe Inflammation

“…Because of overlapping actions of different proinflammatory cytokines, downregulation of sodium transporters cannot be attributed to single cytokines, providing an explanation for why anti-singlecytokine strategies did not improve the outcome of patients with sepsis (37)(38)(39). In addition, our findings contribute to the explanation and understanding of the beneficial effects of glucocorticoids on the outcome of patients with sepsis (52)(53)(54)(55).…”