Corticosteroids for Patients With Septic Shock

Evidence‐based sepsis therapy: A hospitalist perspective

“…50 Might not a robust baseline cortisol suggest sufficient adrenal function regardless of the incremental response to cosyntropin? 51 Partial answers were provided by 2 subsequent meta-analyses. Both found that more recent studies gave lower doses of steroids in longer, 5-to 7-day courses to sicker patients and demonstrated improvement in mortality and shock reversal, with relative risk reductions of 14%-22%; the NNT ranged from 8 to 11.…”