Corticosteroid solubility and lipid polarity control release from solid lipid nanoparticles

Jensen, Lotte; Magnussson, Emily; Gunnarsson, Linda; Vermehren, Charlotte; Nielsen, Hanne Mørck; Petersson, Karsten

doi:10.1016/j.ijpharm.2009.10.022

Cited by 87 publications

(36 citation statements)

References 24 publications

(33 reference statements)

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“…The mechanism of action of TG includes their binding in human receptor found in skin keratinocytes and fibroblasts [3,63]. Some strategies used to increase the skin delivery of topical glucocorticoids include new vehicles such as metered dose aerosol sprays with hydrofluoroalkane [64] and foams [65], chemical enhancers [66], iontophoresis [35] as well as micro and nanoparticles [11,20,51,67,68].…”

Section: Discussionmentioning

confidence: 99%

Submicron polymeric particles prepared by vibrational spray-drying: Semisolid formulation and skin penetration/permeation studies

Beber¹,

Andrade²,

Kann³

et al. 2014

European Journal of Pharmaceutics and Biopharmaceutics

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Topical glucocorticoids (TG) such as dexamethasone (DEX) have been used for decades for the treatment of skin diseases. However, TG present welldocumented side effects and their delivery to the skin is often insufficient.Therefore, many efforts have been undergone to improve the amount of drug delivered to the skin and to reduce side effects at the same time. In this work, the feasibility of DEX-submicron polymeric particles (SP) prepared by vibrational spray-drying as an approach to overcome the challenges associated with the topical administration of this drug class was evaluated. DEX was homogeneously dispersed in the SP matrix, according to confocal Raman microscopy analysis. Drug-loaded SP were incorporated into the oil phase of oil-in-water emulsions (creams). The formulation containing polymeric submicron particles (C-SP) showed controlled drug release kinetics and a significant drug accumulation in skin compared to formulations containing nonpolymeric particles or free drug. DEX accumulation in the stratum corneum was evaluated by tape stripping and a depot effect over time was observed for C-SP, while the formulation containing the free drug showed a decrease over time.Similarly, C-SP presented higher drug retention in epidermis and dermis in skin penetration studies performed on pig skin in Franz diffusion cells, while drug permeation into the receptor compartment was negligible. It was demonstrated, for the first time, the advantageous application of submicron polymeric particles obtained by vibrational spray-drying in semisolid formulations for cutaneous administration to overcome challenges related to the therapy with TG such as DEX.

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Section: Discussionmentioning

confidence: 99%

Submicron polymeric particles prepared by vibrational spray-drying: Semisolid formulation and skin penetration/permeation studies

Beber¹,

Andrade²,

Kann³

et al. 2014

European Journal of Pharmaceutics and Biopharmaceutics

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“…The logP is a common property of drug molecules used to characterize hydrophobicity of compounds. The influence of logP to drug transport was recognized in many experimental studies in which the mass release was governed by hydrophobicity; there, more hydrophobic compounds (higher logP) were released slower [3–8]. Consequently, in case drug release from nanoparticle, it can be found that the release process is more dependent on the partitioning of the drug, than on diffusion through the matrix of the nanoparticle [4].…”

Section: Introductionmentioning

confidence: 99%

Mass partitioning effects in diffusion transport

Kojić

Milošević

et al. 2015

Phys. Chem. Chem. Phys.

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Frequently mass exchange takes place in heterogeneous environment among several phases, where mass partitioning may occur at the interface of phases. Analytical and computational methods for diffusion do not usually incorporate molecule partitioning and masking the true picture of mass transport. Here we present a computational Finite Element methodology to calculate diffusion mass transport with partitioning phenomenon included and the analysis of the effects of partitioning. Our numerical results showed that partitioning controls equilibrated mass distribution as expected from analytics solutions. The experimental validation of mass release from drug-loaded nanoparticles showed that partitioning might even dominate in some cases with respect to diffusion itself. The analysis of diffusion kinetics in the parameter space of partitioning and diffusivity showed that partitioning is extremely important parameters in systems, where mass diffusivity is fast and that the concentration of nanoparticles can control payload retention inside nanoparticles. The computational and experimental results suggest that partitioning and physiochemical properties of phases play important, if not crucial, role in diffusion transport and should be included in studies of mass transport processes.

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“…Cyclosporine Liposomes (Freise et al, 1994;Shah et al, 2006); polymeric NP (Gref et al, 2001;Italia et al, 2007;Azzi et al, 2010;Tang et al, 2012); lipid NP (Muller et al, 2008) Preclinical Tacrolimus Lipid NP (Pople and Singh, 2012); polymeric NP (Tammam et al, 2012); liposomes (Erdogan et al, 2002;Zhang et al, 2010) Preclinical Rapamycin/sirolimus Polymeric NP (Yuan et al, 2008;Woo et al, 2012;Shah et al, 2013); micelles (Yanez et al, 2008;Chen et al, 2013); liposomes (Rouf et al, 2009;Ghanbarzadeh et al, 2013) Preclinical Mycophenolic acid Polymeric NP (Shirali et al, 2011); nanogels (Look et al, 2013); dendrimers (Hu et al, 2009) Preclinical Corticosteroids Liposomes Linker et al, 2008;Schweingruber et al, 2011;Ulmansky et al, 2012); polymeric NP (Ishihara et al, 2005;Matsuo et al, 2009); solid lipid NP (Jensen et al, 2010;Zhang and Smith, 2011); dendrimers (Khandare et al, 2005) Preclinical Non-steroidal anti-inflammatory Dendrimers (Chauhan et al, 2004;Na et al, 2006;Chandrasekar et al, 2007;Cheng et al, 2007); nanocolloid (Milkova et al, 2013); lipid NP (Castelli et al, 2005); liposomes (Paavola et al, 2000;Srinath et al, 2000;Turker et al, 2008)…”

Section: Nanocarrier Statusmentioning

confidence: 99%

Immunosuppressive and Anti-Inflammatory Properties of Engineered Nanomaterials

Ilinskaya

Dobrovolskaia

2016

Handbook of Immunological Properties of Engineered Nanomaterials

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Nanoparticle interactions with various components of the immune system are determined by their physicochemical properties such as size, charge, hydrophobicity and shape. Nanoparticles can be engineered to either specifically target the immune system or to avoid immune recognition. Nevertheless, identifying their unintended impacts on the immune system and understanding the mechanisms of such accidental effects are essential for establishing a nanoparticle's safety profile. While immunostimulatory properties have been reviewed before, little attention in the literature has been given to immunosuppressive and anti-inflammatory properties. The purpose of this review is to fill this gap. We will discuss intended immunosuppression achieved by either nanoparticle engineering, or the use of nanoparticles to carry immunosuppressive or anti-inflammatory drugs. We will also review unintended immunosuppressive properties of nanoparticles per se and consider how such properties could be either beneficial or adverse. LINKED ARTICLESThis article is part of a themed section on Nanomedicine. To view the other articles in this section visit http://dx

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Corticosteroid solubility and lipid polarity control release from solid lipid nanoparticles

Cited by 87 publications

References 24 publications

Submicron polymeric particles prepared by vibrational spray-drying: Semisolid formulation and skin penetration/permeation studies

Submicron polymeric particles prepared by vibrational spray-drying: Semisolid formulation and skin penetration/permeation studies

Mass partitioning effects in diffusion transport

Immunosuppressive and Anti-Inflammatory Properties of Engineered Nanomaterials

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