Corticomedullary Index of Human Kidney

Hassan, SM Nurul; Nargis, Waheeda; Khalil, Mansur; Khalil, M; Alam, Mahabub

doi:10.3329/bja.v10i1.15753

Cited by 3 publications

(3 citation statements)

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“…In this research, the impaired renal function in aged-S rats was consistent with histopathological alterations. The renal cortex was chosen for histopathological assessment because it is more affected by age than the medulla [ 35 ]. The reported histopathological changes in this study were in agreement with those in previous research [ 30 , 36 , 37 ].…”

Section: Discussionmentioning

confidence: 99%

Treadmill Exercise Training Ameliorates Functional and Structural Age-Associated Kidney Changes in Male Albino Rats

Salem

Faried

2021

The Scientific World Journal

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Aging is a biological process that impacts multiple organs. Unfortunately, kidney aging affects the quality of life with high mortality rate. So, searching for innovative nonpharmacological modality improving age-associated kidney deterioration is important. This study aimed to throw more light on the beneficial effect of treadmill exercise on the aged kidney. Thirty male albino rats were divided into three groups: young (3-4 months old), sedentary aged (23-24 months old), and exercised aged (23-24 months old, practiced moderate-intensity treadmill exercise 5 days/week for 8 weeks). The results showed marked structural alterations in the aged kidney with concomitant impairment of kidney functions and increase in arterial blood pressure with no significant difference in kidney weight. Also, it revealed that treadmill exercise alleviated theses effects in exercised aged group with reduction of urea and cystatin C. Exercise training significantly decreased glomerulosclerosis index, tubular injury score, and % area of collagen deposition. Treadmill exercise exerted its beneficial role via a significant reduction of C-reactive protein and malondialdehyde and increase in total antioxidant capacity. In addition, exercise training significantly decreased desmin immunoreaction and increased aquaporin-3, vascular endothelial growth factor, and beclin-1 in the aged kidney. This study clarified that treadmill exercise exerted its effects via antioxidant and anti-inflammatory mechanisms, podocyte protection, improving aquaporin-3 and vascular endothelial growth factor expression, and inducing autophagy in the aged kidney. This work provided a new insight into the promising role of aerobic exercise to ameliorate age-associated kidney damage.

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Section: Discussionmentioning

confidence: 99%

Treadmill Exercise Training Ameliorates Functional and Structural Age-Associated Kidney Changes in Male Albino Rats

Salem

Faried

2021

The Scientific World Journal

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“…This agrees with existing reports. 10,18,26 Brennan 22 in a pilot study had earlier mentioned that low birth weight infants (<2500 g) have a reduced number of glomeruli and nephrons and thus smaller kidneys. Thus, RPT may be useful in the assessment of effect of obesity or acute weight loss on the kidneys in children.…”

Section: Discussionmentioning

confidence: 99%

Sonographic assessment of normal renal parenchymal and medullary pyramid thicknesses among children in Enugu, Southeast, Nigeria

Eze

Akpan²,

Nwadike

2016

Radiography

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“…The relative medullary thickness and the medulla/cortex ratio of the one-humped Arabian camel, both indices of the length of the Loop of Henle and the vasa recta 43 and predictors of maximum concentrating ability 44,45 , have been reported to be 7.89 46 and ~4/1 1,20,36 . In humans, these values are 3.0 47 and ~2.7/1 48 , respectively. This large medullary interface is lined by simple, low cuboidal epithelium which enhances the recycling of urea and water.…”

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Multiomic analysis of the Arabian camel (Camelus dromedarius) kidney reveals a role for cholesterol in water conservation

et al. 2021

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The Arabian camel (Camelus dromedarius) is the most important livestock animal in arid and semi-arid regions and provides basic necessities to millions of people. In the current context of climate change, there is renewed interest in the mechanisms that enable camelids to survive in arid conditions. Recent investigations described genomic signatures revealing evolutionary adaptations to desert environments. We now present a comprehensive catalogue of the transcriptomes and proteomes of the dromedary kidney and describe how gene expression is modulated as a consequence of chronic dehydration and acute rehydration. Our analyses suggested an enrichment of the cholesterol biosynthetic process and an overrepresentation of categories related to ion transport. Thus, we further validated differentially expressed genes with known roles in water conservation which are affected by changes in cholesterol levels. Our datasets suggest that suppression of cholesterol biosynthesis may facilitate water retention in the kidney by indirectly facilitating the AQP2-mediated water reabsorption.

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Corticomedullary Index of Human Kidney

Abstract: Bangladesh Journal of Anatomy, January 2012, Vol. 10 No. 1 pp 20-22 DOI: http://dx.doi.org/10.3329/bja.v10i1.15753

Cited by 3 publications

References 0 publications

Treadmill Exercise Training Ameliorates Functional and Structural Age-Associated Kidney Changes in Male Albino Rats

Treadmill Exercise Training Ameliorates Functional and Structural Age-Associated Kidney Changes in Male Albino Rats

Sonographic assessment of normal renal parenchymal and medullary pyramid thicknesses among children in Enugu, Southeast, Nigeria

Multiomic analysis of the Arabian camel (Camelus dromedarius) kidney reveals a role for cholesterol in water conservation

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