Cortico-cerebellar coordination facilitates neuroprosthetic control

Abbasi, Aamir; Rangwani, Rohit; Bowen, Daniel W.; Fealy, Andrew W.; Danielsen, Nathan P.; Gulati, Tanuj

doi:10.1126/sciadv.adm8246

Cited by 3 publications

(1 citation statement)

References 83 publications

(167 reference statements)

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“…For M1 recordings, 32-channel arrays (33 μm polyamide-coated tungsten microwire arrays) were lowered to a depth of 1,200–1,500 μm in either the left or right M1 depending on handedness. These were implanted centered at 0.5 mm anterior and 3 mm lateral to the bregma ( Ramanathan et al, 2015 ; Lemke et al, 2019 ; Abbasi et al, 2021 , 2024 ; Fleischer et al, 2023 ). For cerebellar recordings, we used 32–64-channel tetrodes (NeuroNexus) or shuttle-mounted polytrodes (Cambridge NeuroTech).…”

Section: Methodsmentioning

confidence: 99%

Modulation of Neural Spiking in Motor Cortex–Cerebellar Networks during Sleep Spindles

Fleischer,

Abbasi,

Gulati

2024

eNeuro

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Sleep spindles appear to play an important role in learning new motor skills. Motor skill learning engages several regions in the brain with two important areas being the motor cortex (M1) and the cerebellum. However, the neurophysiological processes in these areas during sleep, especially how spindle oscillations affect local and cross-region spiking, are not fully understood. We recorded activity from the M1 and cerebellar cortex in 8 rats during spontaneous activity to investigate how sleep spindles in these regions are related to local spiking as well as cross-region spiking. We found that M1 firing was significantly changed during both M1 and cerebellum spindles and this spiking occurred at a preferred phase of the spindle. On average, M1 and cerebellum neurons showed most spiking at the M1 or cerebellum spindle peaks. These neurons also developed a preferential phase-locking to local or cross-area spindles with the greatest phase-locking value at spindle peaks; however, this preferential phase-locking wasn't significant for cerebellar neurons when compared to cerebellum spindles. Additionally, we found the percentage of task-modulated cells in the M1 and cerebellum that fired with non-uniform spike-phase distribution during M1/ cerebellum spindle peaks were greater in the rats that learned a reach-to-grasp motor task robustly. Finally, we found that spindle-band LFP coherence (for M1 and cerebellum LFPs) showed a positive correlation with success rate in the motor task. These findings support the idea that sleep spindles in both the M1 and cerebellum recruit neurons that participate in the awake task to support motor memory consolidation.Significance StatementNeural processing during sleep spindles is linked to memory consolidation. However, little is known about sleep activity in the cerebellum and whether cerebellum spindles can affect spiking activity in local or distant areas. We report the effect of sleep spindles on neuron activity in the M1 and cerebellum—specifically their firing rate and phase-locking to spindle oscillations. Our results indicate that awake practice neuronal activity is tempered during local M1 and cerebellum spindles, and during cross-region spindles, which may support motor skill learning. We describe spiking dynamics in motor networks spindle oscillations that may aid in the learning of skills. Our results support the sleep reactivation hypothesis and suggest that awake M1 activity may be reactivated during cerebellum spindles.

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Section: Methodsmentioning

confidence: 99%

Modulation of Neural Spiking in Motor Cortex–Cerebellar Networks during Sleep Spindles

Fleischer,

Abbasi,

Gulati

2024

eNeuro

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Cortex deviates from criticality during action and deep sleep: a temporal renormalization group approach

Sooter,

Fontenele,

et al. 2024

Preprint

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The hypothesis that the brain operates near criticality explains observations of complex, often scale-invariant, neural activity. However, the brain is not static, its dynamical state varies depending on what an organism is doing. Neurons often become more synchronized (ordered) during unconsciousness and more desynchronized (disordered) in highly active awake conditions. Are all these states equidistant from criticality; if not, which is closest? The fundamental physics of how systems behave near criticality came from renormalization group (RG) theory, but RG for neural systems remains largely undeveloped. Here we developed a temporal RG (tRG) theory for analysis of typical neuroscience data. We mathematically identified multiple types of criticality (tRG fixed points) and developed tRG-driven data analytic methods to assess proximity to each fixed point based on relatively short time series. Unlike traditional methods for studying criticality in neural systems, our tRG approach allows time-resolved measurements of distance from criticality in experiments at behaviorally relevant timescales. We apply our approach to recordings of spike activity in mouse visual cortex, showing that the relaxed, awake state is closest to criticality. When arousal shifts away from this state – either increasing in more active awake states or decreasing in deep sleep – cortical dynamics deviate from criticality.

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EBAX-1/ZSWIM8 destabilizes miRNAs resulting in transgenerational memory of a predatory trait

Quiobe,

Kalirad,

Röseler

et al. 2024

Preprint

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Environmental influences on traits and associated transgenerational epigenetic inheritance have widespread implications, but remain controversial and underlying mechanisms poorly understood. We introduce long-term environmental induction experiments on alternative diets inPristionchus pacificus, a nematode exhibiting mouth-form plasticity including predation, by propagating 110 isogenic lines for 101 generations with associated food-reversal experiments. We found dietary induction and subsequent transgenerational memory of the predatory morph and identified a role of ubiquitin ligase EBAX-1/ZSWIM8 in this process.Ppa-ebax-1mutants have no memory andPpa-EBAX-1 destabilizes the clustered microRNA familymiR-2235a/miR-35.Deletions of a cluster of 44 identicalmiR-2235acopies resulted in precocious and extended transgenerational inheritance of the predatory morph. These findings indicate that EBAX-1/ZSWIM8 destabilizes miRNAs resulting in transgenerational memory, suggesting a role for target-directed miRNA degradation.

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Cortico-cerebellar coordination facilitates neuroprosthetic control

Cited by 3 publications

References 83 publications

Modulation of Neural Spiking in Motor Cortex–Cerebellar Networks during Sleep Spindles

Modulation of Neural Spiking in Motor Cortex–Cerebellar Networks during Sleep Spindles

Cortex deviates from criticality during action and deep sleep: a temporal renormalization group approach

EBAX-1/ZSWIM8 destabilizes miRNAs resulting in transgenerational memory of a predatory trait

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