Cortical thinning related to periventricular and deep white matter hyperintensities

Clinical effect of white matter network disruption related to amyloid and small vessel disease

“…We previously reported that WMH independently affected cognitive impairment regardless of cortical atrophy. 12 Our findings are in line with a recent study that showed that disturbances in WM connectivity explained a substantial proportion of the variance in cognitive function on top of markers of brain atrophy. 10 Furthermore, we found that lacunes affected frontal-executive dysfunction without mediating the WM network or causing cortical atrophy in the frontal lobe.…”

“…With the following evidence, we suggest that the WM network might be a key link between amyloid/SVD burden and cortical atrophy or cognitive impairment: (1) alteration in the WM network was associated with cognitive impairment, 10 (2) propagation of amyloid fibrils and progression of brain atrophy occurred along WM fiber pathways, 11 and (3) the topography of cortical atrophy related to WM hyperintensity (WMH) was similar to cortical regions connected via WM tracts, suggesting that cortical regions that are interconnected via the damaged tracts might become atrophic. 12 We tested the hypothesis that the WM network might be a key link between amyloid/ SVD burden and cortical atrophy or cognitive impairment. We then performed path analyses to evaluate whether the WM network mediates the association between amyloid/SVD burden and cortical atrophy or cognition.…”

“…36 Furthermore, regions of decreased nodal efficiency related to WMH overlapped with regions of cortical atrophy related to WMH. 12 Therefore, it is conceivable that disruption of the WM network by WMH might be related to the development of cortical atrophy. Moreover, sparing of precuneus might be a feature discriminating patients with pure svMCI or pure SVaD from those with AD pathologies.…”

Measurements of lenticulostriate arteries using 7T MRI: new imaging markers for subcortical vascular dementia

“…They met the criteria for SVaD proposed by Erkinjuntti et al [7]. All subjects were given a clinical interview and neurological examination [8].…”

Accelerated progression of white matter hyperintensities and subsequent risk of mortality: a 12-year follow-up study

“…For instance, periventricular (and not deep cortical) WMH is associated with impaired executive function and processing speed (Seo et al, 2012), whereas subjects with depression have higher loads of deep cortical WMH (Sheline et al, 2008). Studies on the association between WMH and mortality have mainly focused on total WMH, and it is unclear whether progression of WMH in different anatomical locations shows differential association in relation to all-cause, cardiovascular, and noncardiovascular mortality.…”