Cortical spreading depression modulates the caudate nucleus activity

Seghatoleslam, Masoumeh; Ghadiri, Maryam Khaleghi; Ghaffarian, Nikoo; Speckmann, Erwin‐Josef; Gorji, Ali

doi:10.1016/j.neuroscience.2014.02.029

Cited by 23 publications

(11 citation statements)

References 42 publications

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“…The caudate nucleus seems to be involved in migraine attacks (21) and chronification (22) because this nucleus receives sensory input from the trigeminovascular neurons (7,23). Compared to low frequency migraineurs, high frequency migraineurs have differences in caudate functional connectivity and morphology (22).…”

Section: Discussionmentioning

confidence: 99%

Functional connectivity of hypothalamus in chronic migraine with medication overuse

Lerebours

Boulanouar²,

Barége

et al. 2019

Cephalalgia

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Objective To investigate the functional connectivity of the hypothalamus in chronic migraine compared to interictal episodic migraine in order to improve our understanding of migraine chronification. Methods Using task-free fMRI and ROI-to-ROI analysis, we compared anterior hypothalamus intrinsic connectivity with the spinal trigeminal nucleus in patients with chronic migraine (n = 25) to age- and sex-matched patients with episodic migraine in the interictal phase (n = 22). We also conducted a seed-to-voxel analysis with anterior hypothalamus as a seed. Results All patients with chronic migraine had medication overuse. We found a significant connectivity (T = 2.08, p = 0.024) between anterior hypothalamus and spinal trigeminal nucleus in the chronic group, whereas these two regions were not connected in the episodic group. The strength of connectivity was not correlated with pain intensity (rho: 0.09, p = 0.655). In the seed-to-voxel analysis, three regions were more connected with the anterior hypothalamus in the chronic group: The spinal trigeminal nuclei (MNI coordinate x = 2, y = −44, z = −62), the right dorsal anterior insula (MNI coordinate x = 10, y = 10, z = 18), and the right caudate (MNI coordinate x = 12, y = 28, z = 6). However, these correlations were no longer significant after whole brain FWE correction. Conclusion An increased functional connectivity between the anterior hypothalamus and the spinal trigeminal nucleus, as previously reported in preictal episodic migraine, was demonstrated in chronic migraine with medication overuse. This finding confirms a major role of the anterior hypothalamus in migraine and suggests that chronic migraineurs are locked in the preictal phase.

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Section: Discussionmentioning

confidence: 99%

Functional connectivity of hypothalamus in chronic migraine with medication overuse

Lerebours

Boulanouar²,

Barége

et al. 2019

Cephalalgia

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“…The caudate nucleus, as part of a prefrontal‐striatal‐thalamic circuit, plays a central role in cognitive processes, particularly executive functions, emotion and behaviour (Grahn et al., ; Foerde and Shohamy, ). Moreover, it is known that the caudate nucleus is involved in pain processing (Schweinhardt et al., ; Seghatoleslam et al., ). We speculated that the decreased volumes in the caudate nucleus could lead to disturb sensory pathways and might bias PDM subjects towards unpleasant or painful perceptions from the viscera.…”

Section: Discussionmentioning

confidence: 99%

Altered regional cortical thickness and subcortical volume in women with primary dysmenorrhoea

Liu

Yang

Wang

et al. 2015

European Journal of Pain

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“…The caudate nucleus is a part of basal ganglia and is related to motor tasks and may contribute to pain as well as changes in cognition and behavior in patients with migraine 56. The acute EP patients in our study showed lower GMV values in the left caudate, which indicates caudate dysfunction.…”

Section: Discussionmentioning

confidence: 49%

Gray Matter Volume Changes in Patients With Acute Eye Pain: A Voxel-Based Morphometry Study

Lan

Zhu

et al. 2019

Trans. Vis. Sci. Tech.

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PurposeThe present study was attempted to compare the differences in gray matter volume (GMV) between the acute eye pain (EP) patients and the healthy controls (HCs) using voxel-based morphometry (VBM), and to explore the relationship with clinical features and behavioral performance.MethodsA total of 24 patients (17 males, 7 females) with acute EP and 24 (17 males, 7 females) age-, sex-, and education-matched HCs were recruited from the Ophthalmology Department of the First Affiliated Hospital of Nanchang University. Functional magnetic resonance imaging (fMRI) scans were conducted in all subjects. We analyzed the original three-dimensional (3D) T1 brain images by VBM and compared the GMV values with the HCs. The acute EP patients can be distinguished from the HCs by receiver operating characteristic (ROC) curve.ResultsCompared with HCs, the acute EP patients had significantly lower GMV values in the brain regions of the left cerebellum posterior lobe, the left limbic lobe, the right insula, the left insula, the left thalamus, the left caudate, and the right cuneus. In addition, the WMV values of the whole brain in acute EP patients decreased slightly.ConclusionsThese results demonstrated that the acute EP patients showed an abnormal reduction in GMV in some brain regions, which might provide valuable information for further exploration of underlying neural mechanisms. These abnormal brain regions may reflect the functional disorders of acute EP patients in somatosensory, motor, cognitive functions, and so on.Translational RelevanceThe VBM study provides a diagnostic method for identifying the cause of acute EP, additionally, a novel direction was presented for further exploration of underlying neural mechanisms of acute EP.

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Cortical spreading depression modulates the caudate nucleus activity

Cited by 23 publications

References 42 publications

Functional connectivity of hypothalamus in chronic migraine with medication overuse

Functional connectivity of hypothalamus in chronic migraine with medication overuse

Altered regional cortical thickness and subcortical volume in women with primary dysmenorrhoea

Gray Matter Volume Changes in Patients With Acute Eye Pain: A Voxel-Based Morphometry Study

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