Cortical potentials preceding voluntary finger movement in patients with focal cerebellar lesion

Kitamura, Junichi; Shabasaki, Hiroshi; Terashi, Akiro; Tashima, Keiho

doi:10.1016/s0168-5597(98)00052-5

Cited by 30 publications

(21 citation statements)

References 25 publications

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“…Moreover, cerebellar activity was found to be reduced for self‐generated movements resulting in tactile stimulation compared with a movement without causing tactile stimulation, indicating that cerbellar activity is related to (predicted) movement consequences 143. In accordance with this finding, the readiness potential, reflecting movement preparation, is reduced in patients with lesions affecting the cerebellar dentate nucleus 144…”

Section: Potential Mechanisms Of Cerebellar Involvement In Cognitionsupporting

confidence: 54%

Mechanisms of cerebellar contributions to cognition in humans

Bellebaum

Daum

Suchan

2012

WIRES Cognitive Science

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The role of the human cerebellum in cognitive processes is the subject of ongoing debate. On the basis of neuroanatomical findings of closed cerebro-cerebellar loops in monkeys, which originate not only in motor but also in nonmotor regions of the cerebral cortex, this article addresses mechanisms of the involvement of the human cerebellum in two well-studied cognitive domains, executive function, working memory in particular, and associative learning, with special emphasis on the nature of a potential cerebellar contribution to these cognitive processes. The uniform organization of cortico-cerebellar connections suggests parallels in cerebellar information processing in motor- and nonmotor contexts. Taking into account recent models on cerebellar function, it is suggested that the main contribution of the cerebellum to motor as well as to cognitive tasks may be to provide accurate predictions of future sensations, actions, and events. WIREs Cogn Sci 2012, 3:171-184. doi: 10.1002/wcs.1161 For further resources related to this article, please visit the WIREs website.

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Section: Potential Mechanisms Of Cerebellar Involvement In Cognitionsupporting

confidence: 54%

Mechanisms of cerebellar contributions to cognition in humans

Bellebaum

Daum

Suchan

2012

WIRES Cognitive Science

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“…Magnetoencephalography shows that cerebellar activation anticipates sensory stimuli up to 4 s in advance (Tesche and Karhu, 2000). The cerebellum has an active role in this network, as dentate lesions attenuate the readiness potential (i.e., the Bereitschaftspotential; Kitamura et al, 1999), a major anticipatory marker for self-initiated movements generated in the motor cortices (Deecke et al, 1976; Neshige et al, 1988; Ikeda et al, 1995). Another interesting observation is cerebellar involvement in the 3-4 s integration window present in motor, sensory and cognitive processes, considered to represent the “subjective present” (Bechinger et al, 1969; Fraisse, 1984; Mates et al, 1994).…”

Section: Discussionmentioning

confidence: 99%

Long-Term Predictive and Feedback Encoding of Motor Signals in the Simple Spike Discharge of Purkinje Cells

Popa

Streng

Ebner

2017

eNeuro

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Most hypotheses of cerebellar function emphasize a role in real-time control of movements. However, the cerebellum’s use of current information to adjust future movements and its involvement in sequencing, working memory, and attention argues for predicting and maintaining information over extended time windows. The present study examines the time course of Purkinje cell discharge modulation in the monkey (Macaca mulatta) during manual, pseudo-random tracking. Analysis of the simple spike firing from 183 Purkinje cells during tracking reveals modulation up to 2 s before and after kinematics and position error. Modulation significance was assessed against trial shuffled firing, which decoupled simple spike activity from behavior and abolished long-range encoding while preserving data statistics. Position, velocity, and position errors have the most frequent and strongest long-range feedforward and feedback modulations, with less common, weaker long-term correlations for speed and radial error. Position, velocity, and position errors can be decoded from the population simple spike firing with considerable accuracy for even the longest predictive (-2000 to -1500 ms) and feedback (1500 to 2000 ms) epochs. Separate analysis of the simple spike firing in the initial hold period preceding tracking shows similar long-range feedforward encoding of the upcoming movement and in the final hold period feedback encoding of the just completed movement, respectively. Complex spike analysis reveals little long-term modulation with behavior. We conclude that Purkinje cell simple spike discharge includes short- and long-range representations of both upcoming and preceding behavior that could underlie cerebellar involvement in error correction, working memory, and sequencing.

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“…Patients with cerebellar lesions restricted to the dentate nucleus show a marked attenuation of the readiness potential for self-initiated movements (Kitamura and others 1999), indicating that the cerebellum may be the origin of the temporal delay necessary to maintain anticipatory PFC-IPL activity. Task-to-task variability in this delay period, perhaps resulting from cerebellar signals, may result in decreased PFC-IPL coherence (Carmel and others 2006).…”

Section: Cerebellar Role In Predictionmentioning

confidence: 99%

“…Cerebellar lesions have also been associated with impairments on tasks requiring rapid shifts in attention (Fiez and others 1992; Riva and Giorgi 2000; Gottwald and others 2004; Molinari and others 2004), although these deficits may be related to a resource allocation problem given the increased demands on these patients to prepare and produce responses (Ravizza and Ivry 2001). In addition, patients with cerebellar or cerebellar outflow tract lesions show an attenuation of the readiness potential or the CNV (Ikeda and others 1994; Kitamura and others 1999), as well as a reduction in activity in the contralateral parietal cortex (Lauritzen 2001). …”

Section: Cerebellar Role In Predictionmentioning

confidence: 99%

The Predictive Brain State: Asynchrony in Disorders of Attention?

Ghajar

Ivry

2008

Neuroscientist

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It is postulated that a key function of attention in goal-oriented behavior is to reduce performance variability by generating anticipatory neural activity that can be synchronized with expected sensory information. A network encompassing the prefrontal cortex, parietal lobe, and cerebellum may be critical in the maintenance and timing of such predictive neural activity. Dysfunction of this temporal process may constitute a fundamental defect in attention, causing working memory problems, distractibility, and decreased awareness.

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Cortical potentials preceding voluntary finger movement in patients with focal cerebellar lesion

Cited by 30 publications

References 25 publications

Mechanisms of cerebellar contributions to cognition in humans

Mechanisms of cerebellar contributions to cognition in humans

Long-Term Predictive and Feedback Encoding of Motor Signals in the Simple Spike Discharge of Purkinje Cells

The Predictive Brain State: Asynchrony in Disorders of Attention?

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