Cortical motor neurophysiology of patients with schizophrenia: A study using transcranial magnetic stimulation

Soubasi, Evanthia; Chroni, Elisabeth; Gourzis, Philippos; Zisis, Th.; Beratis, Stavroula; Papathanasopoulos, Panayiotis

doi:10.1016/j.psychres.2009.04.003

Cited by 25 publications

(22 citation statements)

References 36 publications

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“…For example, the rMT can vary depending on whether the subject is contracting or relaxing the muscles, on the position of the subject's hand [60], and on the subject's medication [61,62]. Thus, functional disturbances [63] could affect the rMT measurement, leading to an approximate reflection of global cortical excitability in patients with schizophrenia. Investigating cortical excitability in the primary motor cortex might imperfectly reflect the cortical excitability in the temporal cortex in patients with schizophrenia.…”

Section: Discussionmentioning

confidence: 99%

Cortical Anatomical Variations and Efficacy of rTMS in the Treatment of Auditory Hallucinations

et al. 2015

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Section: Discussionmentioning

confidence: 99%

Cortical Anatomical Variations and Efficacy of rTMS in the Treatment of Auditory Hallucinations

et al. 2015

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“…42 Studies assessing GABA B -mediated inhibition in SCZ have produced varied results. For instance, in both chronic medicated and unmedicated SCZ patients, one study assessing LICI found no difference with controls, 43 whereas in studies assessing SP, decreased, 28,29,31,37,44 incr eased, 23,25,36,45,46 and comparable 27,47-50 duration has been reported. Two studies assessing first-episode patients reported increased SP early in the illness.…”

Section: Gaba B -Mediated Inhibitionmentioning

confidence: 98%

Cortical Inhibition, Excitation, and Connectivity in Schizophrenia: A Review of Insights From Transcranial Magnetic Stimulation

Rogasch

Daskalakis

Fitzgerald

2013

Schizophrenia Bulletin

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Schizophrenia (SCZ) is a debilitating mental illness with an elusive pathophysiology. Over the last decade, theories emphasizing cortical dysfunction have received increasing attention to explain the heterogeneous symptoms experienced in SCZ. Transcranial magnetic stimulation (TMS) is a noninvasive form of brain stimulation that is particularly suited to probing the fidelity of specific excitatory and inhibitory neuronal populations in conscious humans. In this study, we review the contribution of TMS in assessing inhibitory and excitatory neuronal populations and their long-range connections in SCZ. In addition, we discuss insights from combined TMS and electroencephalography into the functional consequences of impaired excitation/ inhibition on cortical oscillations in SCZ.

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“…benzodiazepines (74), anticonvulsants (109 2006), antidepressants (79) and others (110)) and/or presenting neuropsychiatric disorders (e.g. major depression (111), schizophrenia (112), fibromyalgia (113), migraine (114), and others); an issue that is likely to interfere with the chosen dosage. Finally, other variables influence baseline cortical excitability such as gender (115), age (116) and smoking (117).…”

Section: The Clinical Research Of Transcranial Direct Current Stimmentioning

confidence: 99%

Clinical research with transcranial direct current stimulation (tDCS): Challenges and future directions

et al. 2012

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Background Transcranial direct current stimulation (tDCS) is a neuromodulatory technique that delivers low-intensity, direct current to cortical areas facilitating or inhibiting spontaneous neuronal activity. In the past ten years, tDCS physiological mechanisms of action have been intensively investigated giving support for the investigation of its applications in clinical neuropsychiatry and rehabilitation. However, new methodological, ethical, and regulatory issues emerge when translating the findings of preclinical and phase I studies into phase II and III clinical studies. The aim of this comprehensive review is to discuss the key challenges of this process and possible methods to address them. Methods We convened a workgroup of researchers in the field to review, discuss and provide updates and key challenges of neuromodulation use for clinical research. Main Findings/Discussion We reviewed several basic and clinical studies in the field and identified potential limitations, taking into account the particularities of the technique. We review and discuss the findings into four topics: (i) mechanisms of action of tDCS, parameters of use and computer-based human brain modeling investigating electric current fields and magnitude induced by tDCS; (ii) methodological aspects related to the clinical research of tDCS as divided according to study phase (i.e., preclinical, phase I, phase II and phase III studies); (iii) ethical and regulatory concerns; (iv) future directions regarding novel approaches, novel devices, and future studies involving tDCS. Finally, we propose some alternative methods to facilitate clinical research on tDCS.

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Cortical motor neurophysiology of patients with schizophrenia: A study using transcranial magnetic stimulation

Cited by 25 publications

References 36 publications

Cortical Anatomical Variations and Efficacy of rTMS in the Treatment of Auditory Hallucinations

Cortical Anatomical Variations and Efficacy of rTMS in the Treatment of Auditory Hallucinations

Cortical Inhibition, Excitation, and Connectivity in Schizophrenia: A Review of Insights From Transcranial Magnetic Stimulation

Clinical research with transcranial direct current stimulation (tDCS): Challenges and future directions

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