Cortical bone viscoelastic damping assessed with resonant ultrasound spectroscopy reflects porosity and mineral content

Fan, Fan; Cai, Xiran; Follet, Hélène; Peyrin, Françoise; Laugier, Pascal; Niu, Haijun; Grimal, Quentin

doi:10.1016/j.jmbbm.2021.104388

Cited by 8 publications

(5 citation statements)

References 43 publications

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“…Our results suggest that Q 11 1 could be of clinical interest as it is correlated with Ct.vBMD (R 0.92 2 = , figure 4). Furthermore, Fan et al (2021) have shown that the shear wave quality factor is correlated to porosity (R 2 =0.53), and it is reasonable to infer that Q 11 1 measured in this study is also related to porosity.…”

Section: Discussionsupporting

confidence: 57%

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In vivo pulse-echo measurement of apparent broadband attenuation and Q factor in cortical bone: a preliminary study

Minonzio¹,

Han²,

Cassereau³

et al. 2021

Phys. Med. Biol.

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Quantitative UltraSound (QUS) methods have been introduced to assess cortical bone health at the radius and tibia through the assessment of Cortical Thickness (Ct.Th), Cortical Porosity (Ct.Po) and bulk wave velocities. Ultrasonic attenuation is another QUS parameter which is not currently used. We assess the feasibility of in vivo measurement of ultrasonic attenuation in cortical bone with a broadband transducer with 3.5 MHz-center frequency. Echoes from the periosteal and endosteal interfaces were fitted with Gaussian pulses using sparse signal processing. Then, the slope of the Broadband Ultrasonic Attenuation (Ct.nBUA) in cortical bone and quality factor Q −1

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Section: Discussionsupporting

confidence: 57%

“…4). Furthermore, Fan et al (2021) have shown that the shear wave quality factor is correlated to porosity (R 2 =0.53), and it is reasonable to infer that…”

Section: Discussionmentioning

confidence: 98%

In vivo pulse-echo measurement of apparent broadband attenuation and Q factor in cortical bone: a preliminary study

Minonzio¹,

Han²,

Cassereau³

et al. 2021

Phys. Med. Biol.

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“…Another limitation of this work was the lack of validation of the shape-optimized stems obtained by the finite element simulations with other experimental or clinical assessments. Furthermore, the mechanical properties of femur bone was considered to be linearly elastic in this study, while the femur bone tissue exhibits minor viscoelastic behavior (Fan et al 2021). The viscoelastic properties of the femur bone may affect the amount of all three failure mechanisms of hip implants used as the objective functions including the stress shielding, initial relative micro-motion, and bone-implant interface stress.…”

Section: Discussionmentioning

confidence: 99%

Multi-objective shape optimization of a cementless femoral stem using the MOPSO algorithm

Yazdi,

Kazemirad

2024

Preprint

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The geometrical shape of the femoral component of hip implants plays a key role in the long-term survivorship of hip implants. The aim of this study was to propose a multi-objective shape optimization procedure using the MOPSO algorithm with three shape-dependent failure mechanisms of hip implants as objective functions including the stress shielding, initial relative micro-motion, and bone-implant interface stress. The Taperloc® Complete femoral stem was selected and its reference geometry was defined with sixty-seven variables. Ten new stem shapes were produced as the swarm members by randomly changing the values of the variables. The values of the three objectives for each stem shape were calculated by the finite element analysis and the position of each swarm member was updated iteratively using the MOPSO algorithm. The geometry that caused a 37% and 33% decrease in the interface stress and stress shielding, respectively, and a 32% increase in the initial micro-motion compared to the Taperloc® Complete stem was selected as the optimized shape. It was shown that thinning the femoral stems without changing their length reduced the induced stress shielding and initial micro-motion and increased the interface stress, whereas shortening the femoral stems reduced the stress shielding and interface stress and increased the initial micro-motion. The proposed procedure may be conveniently used for the shape optimization of commercial femoral stems, which may significantly impact the performance and lifetime of hip implants.

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“…Other metrics beyond HU that directly impact ultrasound propagation through the skull, such as bone porosity and mineral content 36 may allow for improved characterization of cortical and diploë bone properties. One recent study found a difference in ultrasonic imaging contrast for bones with equal porosity but varying pore size, 37 indicating that pore size variations affect the beam transmission.…”

Section: Discussionmentioning

confidence: 99%

The influence of bone model geometries on the determination of skull acoustic properties

Marchant,

Clinard,

Odéen

et al. 2023

Numer Methods Biomed Eng

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In this study, we investigated the impact of various simulated skull bone geometries on the determination of skull speed of sound and acoustic attenuation values via optimization using transmitted pressure amplitudes beyond the bone. Using the hybrid angular spectrum method (HAS), we simulated ultrasound transmission through four model sets of different geometries involving sandwiched layers of diploë and cortical bone in addition to three models generated from CT images of ex‐vivo human skull‐bones. We characterized cost‐function solution spaces for each model and, using optimization, found that when a model possessed appreciable variations in resolvable layer thickness, the predefined attenuation coefficients could be found with low error (RMSE < 0.01 Np/cm). However, we identified a spatial frequency cutoff in the models' geometry beyond which the accuracy of the property determination begins to fail, depending on the frequency of the ultrasound source. There was a large increase in error of the attenuation coefficients determined by the optimization when the variations in layer thickness were above the identified spatial frequency cutoffs, or when the lateral variations across the model were relatively low in amplitude. For our limited sample of three CT‐image derived bone models, the attenuation coefficients were determined successfully. The speed of sound values were determined with low error for all models (including the CT‐image derived models) that were tested (RMSE < 0.4 m/s). These results illustrate that it is possible to determine the acoustic properties of two‐component models when the internal bone structure is taken into account and the structure satisfies the spatial frequency constraints discussed.

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Cortical bone viscoelastic damping assessed with resonant ultrasound spectroscopy reflects porosity and mineral content

Cited by 8 publications

References 43 publications

In vivo pulse-echo measurement of apparent broadband attenuation and Q factor in cortical bone: a preliminary study

In vivo pulse-echo measurement of apparent broadband attenuation and Q factor in cortical bone: a preliminary study

Multi-objective shape optimization of a cementless femoral stem using the MOPSO algorithm

The influence of bone model geometries on the determination of skull acoustic properties

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