Corrigendum to “Metalloproteinases and Their Tissue Inhibitors in Comparison between Different Chronic Pneumopathies in the Horse”

Barton, Ann Kristin; Shety, Tarek; Bondzio, Angelika; Einspanier, Ralf; Gehlen, Heidrun

doi:10.1155/2017/7825942

Cited by 1 publication

(1 citation statement)

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“…MiR-146-5p targets inflammatory mediators like COX2, IL-1β, KIT, NFKB1, TLR4, TRAF6 , and UHRF1 [ 78 ] and has been proposed as a predictor for asthma exacerbations in childhood asthma [ 79 , 80 ]. The anti-inflammatory miR-135b acts by targeting FOXN3 and RECK , an inhibitor of MMP2, and the known sEA pathogenesis factor MMP9 [ 81 , 82 , 83 ]. These anti-inflammatory actions might be the immunological counterbalance, and thus the defense mechanism of the lung against acute inflammation (likely Th17-mediated, as outlined above) during disease exacerbation.…”

Section: Discussionmentioning

confidence: 99%

An Integrative miRNA-mRNA Expression Analysis Reveals Striking Transcriptomic Similarities between Severe Equine Asthma and Specific Asthma Endotypes in Humans

Hulliger

Pacholewska

Vargas

et al. 2020

Genes

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Severe equine asthma is an incurable obstructive respiratory condition affecting 10–15% of horses in temperate climates. Upon exposure to airborne antigens from hay feeding, affected horses show neutrophilic airway inflammation and bronchoconstriction, leading to increased respiratory effort. The resulting implications range from welfare concerns to economic impacts on equestrian sports and horse breeding. Immunological and pathophysiological characteristics of severe equine asthma show important parallels with allergic and severe neutrophilic human asthma. Our study aimed at investigating regulatory networks underlying the pathophysiology of the disease by profiling miRNA and mRNA expression in lung tissue samples from asthmatic horses compared with healthy controls. We sequenced small RNAs and mRNAs from lungs of seven asthmatic horses in exacerbation, five affected horses in remission, and eight healthy control horses. Our comprehensive differential expression analyses, combined with the miRNA–mRNA negative correlation approach, revealed a strong similarity on the transcriptomic level between severe equine asthma and severe neutrophilic asthma in humans, potentially through affecting Th17 cell differentiation. This study also showed that several dysregulated miRNAs and mRNAs are involved in airway remodeling. These results present a starting point for a better transcriptomic understanding of severe equine asthma and its similarities to asthma in humans.

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