Corrigendum to “Hydrogen Sulfide Prevents Formation of Reactive Oxygen Species through PI3K/Akt Signaling and Limits Ventilator‐Induced Lung Injury”

Spassov, Sashko; Donus, Rosa; Ihle, Paul Mikael; Engelstaedter, Helen; Hoetzel, Alexander; Faller, Simone

doi:10.1155/2017/9230134

Cited by 4 publications

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“…Conspicuously, inhibiting TLR2/4 signaling averts translocation of NF-κB and activation of JNK which would eventually lead to preventing cell apoptosis ( Li et al, 2014 ). Additionally, another study showed that the anti-apoptotic and anti-inflammatory effects of exogenous H 2 S may be mediated by inhibiting JNK phosphorylation ( Li X. et al, 2019 ), downregulation of NF-κB ( Li et al, 2016 ), or by direct inhibition of ROS production ( Spassov et al, 2017 ). Consequently, it is possible that the neutral effect of PAG pretreatment on hepatic caspase-3 expression might be linked to its non-significant effect on the oxidative status of CP-treated rats.…”

Section: Discussionmentioning

confidence: 99%

TLRs-JNK/ NF-κB Pathway Underlies the Protective Effect of the Sulfide Salt Against Liver Toxicity

Abdel‐latif

Heeba

Hassanin³

et al. 2022

Front. Pharmacol.

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Hydrogen sulfide (H2S) is an endogenously gas transmitter signaling molecule with known antioxidant, anti-inflammatory, and cytoprotective properties. Although accumulating evidence shows the therapeutic potential of H2S in various hepatic diseases, its role in cyclophosphamide (CP)-induced hepatotoxicity remains elusive. The present study was undertaken to investigate the impact of endogenous and exogenous H2S on toll-like receptors (TLRs)-mediated inflammatory response and apoptosis in CP-induced hepatotoxicity. Either an H2S donor (NaHS (100 μM/kg) or an H2S blocker [dl-propargylglycine (PAG) (30 mg/kg, i. p.)], was administered for 10 days before a single ip injection of CP (200 mg/kg). NaHS attenuated conferred hepatoprotection against CP-induced toxicity, significantly decreasing serum hepatic function tests and improving hepatic histopathology. Additionally, NaHS-treated rats exhibited antioxidant activity in liver tissues compared with the CP group. The upregulated hepatic levels of TLR2/4 and their downstream signaling molecules including c-Jun N-terminal kinase (JNK) and nuclear factor-kappa B (NF-κB) were also suppressed by NaHS protective treatment. NaHS showed anti-inflammatory and antiapoptotic effects; reducing hepatic level tumor necrosis factor-alpha (TNF-α) and caspase-3 expression. Interestingly, the cytotoxic events induced in CP-treated rats were not significantly altered upon the blocking of endogenous H2S. Taken together, the present study suggested that exogenously applied H2S rather than the endogenously generated H2S, displayed a hepatoprotective effect against CP-induced hepatotoxicity that might be mediated by TLRs-JNK/NF-κB pathways.

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