Corrigendum to “Dux4 induces cell cycle arrest at G1 phase through up regulation of p21 expression” [Biochem. Biophys. Res. Commun. 446 (2014) 235–240]

Xu, Hong‐Liang; Wang, Zhaoxia; Jin, Suqin; Hao, Hongjun; Zheng, Lemin; Zhou, Boda; Zhang, Wei; Lv, He; Yuan, Yun

doi:10.1016/j.bbrc.2014.05.126

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“…Notably, two major 4q subtelomeric allelic variants exist (4qA and 4qB), but only the 4qA allele provides a polymorphic DUX4 polyadenylation signal, which makes it permissive for DUX4 expression in skeletal muscle [ 63 , 64 ]. As described below, in FSHD, DUX4 has been associated with activation of pathways toxic to muscle tissue [ 50 , 65 , 66 ], including oxidative stress and DNA damage [ 67 , 68 ], inhibition of myogenic differentiation [ 67 , 69 , 70 , 71 ], impaired transcript quality control [ 54 , 72 , 73 ] and inflammation [ 40 ], leading to muscle cell apoptosis [ 67 , 74 , 75 ].…”

Section: Pathological Role Of Dux4mentioning

confidence: 99%

DUX4 Role in Normal Physiology and in FSHD Muscular Dystrophy

Mocciaro

Runfola

Ghezzi

et al. 2021

Cells

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In the last decade, the sequence-specific transcription factor double homeobox 4 (DUX4) has gone from being an obscure entity to being a key factor in important physiological and pathological processes. We now know that expression of DUX4 is highly regulated and restricted to the early steps of embryonic development, where DUX4 is involved in transcriptional activation of the zygotic genome. While DUX4 is epigenetically silenced in most somatic tissues of healthy humans, its aberrant reactivation is associated with several diseases, including cancer, viral infection and facioscapulohumeral muscular dystrophy (FSHD). DUX4 is also translocated, giving rise to chimeric oncogenic proteins at the basis of sarcoma and leukemia forms. Hence, understanding how DUX4 is regulated and performs its activity could provide relevant information, not only to further our knowledge of human embryonic development regulation, but also to develop therapeutic approaches for the diseases associated with DUX4. Here, we summarize current knowledge on the cellular and molecular processes regulated by DUX4 with a special emphasis on FSHD muscular dystrophy.

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