Corrigendum to “Does Comorbidity Increase the Risk of Dengue Hemorrhagic Fever and Dengue Shock Syndrome?”

Mahmood, Shahıd; Hafeez, Saadia; Nabeel, Hibbah; Zahra, Urooj; Nazeer, Hammad

doi:10.1155/2017/2725850

Cited by 15 publications

(3 citation statements)

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“…Our study showed that delayed hospitalization tends to lead the patient in severity of the disease and these results are in accordance with the previous studies [ 4 , 39 ]. Increased in bleeding tendencies, delayed in hospitalization [ 39 ], hospital admission with warning signs [ 40 , 41 ], co-morbidities [ 42 ] are all associated risk factors of DHF. These findings are harmonious with the reported studies [ 4 , 31 ].…”

Section: Discussionmentioning

confidence: 99%

“…Statistically we found that there is strong association of diabetes mellitus (DM) with DHF while the patient suffering from DM individually had higher odds for developing DHF than patients without disease. Increased capillary fragility and permeability due to activation of T lymphocytes and release of cytokines in DM are might be some possible factors of development of DHF dengue [ 22 , 42 ]. Secondary infection was associated with DHF cases more than DF (Table 4 ), but there was no statistical association between secondary infection and the development of DHF.…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of clinical and laboratory characteristics of dengue viral infection and risk factors of dengue hemorrhagic fever: a multi-center retrospective analysis

Riaz,

Harun,

Mallhi

et al. 2024

BMC Infect Dis

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Background Dengue Viral Infection (DVI) has become endemic in Pakistan since the first major outbreak in Karachi in 1996. Despite aggressive measures taken by relevant authorities, Pakistan has been dealing with a worsening dengue crisis for the past two decades. DHF is severe form of dengue infection which is linked with significant morbidity and mortality. Early identification of severe dengue infections can reduce the morbidity and mortality. In this context we planned current study in which we find out the different factors related with DHF as well as clinical laboratory features of DHF and compare them to DF so that patients can be best evaluated for DHF and managed accordingly at admission. Methods Retrospective study conducted over a period of 6 years (2013–2018) in two tertiary care hospitals in Pakistan. Data were collected by using a pre-structured data collection form. Data were statistically analyzed to determine the clinical and laboratory characteristics of DVI and risk factors of dengue hemorrhagic fever (DHF). Results A total 512 dengue cases (34.05 ± 15.08 years; Male 69.53%) were reviewed. Most common clinical manifestations of DVI were fever (99.60%), headache (89.1%), chills (86.5%), rigors (86.5%), myalgia (72.3%). Less common clinical manifestations were vomiting (52.5%), arthralgia (50.2%) and skin rashes (47.5%). Furthermore, nasal bleeding (44.1%), gum bleeding (32.6%), pleural effusion (13.9%) and hematuria (13.1%) were more profound clinical presentations among DHF patients. Mortality rate was 1.5% in this study. Logistic regression analysis indicated that delayed hospitalization (OR: 2.30) and diabetes mellitus (OR:2.71), shortness of breath (OR:2.21), association with risk groups i.e., living near stagnant water, travelling to endemic areas, living in endemic regions (OR:1.95), and presence of warning signs (OR:2.18) were identified as risk factors of DHF. Statistically we found that there is strong association of diabetes mellitus (DM) with DHF while the patient suffering from DM individually had higher odds (2.71) of developing DHF than patients without disease. Conclusions The current study demonstrated that the clinical and laboratory profiles of DF and DHF are significantly distinct. Significant predictors of DHF were advanced age, diabetes mellitus, ascites, pleural effusion, thick gallbladder and delayed hospitalization. The identification of these factors at early stage provides opportunities for the clinicians to identify high risk patients and to reduce dengue-related morbidity and mortality.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Evaluation of clinical and laboratory characteristics of dengue viral infection and risk factors of dengue hemorrhagic fever: a multi-center retrospective analysis

Riaz,

Harun,

Mallhi

et al. 2024

BMC Infect Dis

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“…The presence of comorbid conditions such as hypertension and diabetes mellitus was relatively low in our cohort, which may limit the generalizability of our findings to populations with higher prevalence of these conditions. Previous research has indicated that comorbidities can impact the clinical course of dengue fever and may influence the host's lipid metabolism [11] .…”

Section: Discussionmentioning

confidence: 99%

Alterations in plasma lipid levels as potential predictive markers for clinical prognosis in dengue fever

Vaishnavi,

Geetha,

Gowrishankar

2024

Int. J. Mosq. Res.

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Introduction: Dengue fever, a mosquito-borne viral infection, presents with varying clinical manifestations that can progress to severe outcomes. Recent studies suggest alterations in plasma lipid profiles may predict disease severity, yet the mechanisms and prognostic value of these changes remain unclear. Aim of the present study was to investigate changes in plasma lipid profiles during dengue infection and assess their potential as predictive biomarkers for disease severity and clinical outcomes. Materials and Methods: This prospective observational study included 150 confirmed cases of dengue fever from the Department of General Medicine at a tertiary care hospital. Plasma lipid profiles (total cholesterol, HDL, LDL, VLDL cholesterol, and triglycerides) were measured in the acute phase and convalescent phase. Baseline demographic and clinical characteristics were analyzed, and their associations with lipid profile changes and disease severity were evaluated. Results: Significant increases in total cholesterol, HDL, LDL, and triglycerides were observed from the acute to the convalescent phase (p-values: 0.001, < 0.001, 0.002, and 0.01, respectively). VLDL cholesterol also showed an upward trend (p=0.05). Patients with more severe forms of dengue (DHF, DSS) exhibited more pronounced lipid alterations. Baseline characteristics indicated a median age of 35 years, with a slight male predominance (60%) and a majority presenting without comorbid conditions (80%). Conclusions: Plasma lipid profile alterations during dengue infection correlate with disease severity, suggesting their potential utility as biomarkers for predicting clinical outcomes. Further research is needed to understand the mechanisms driving these changes and to validate their prognostic value, which could lead to improved diagnostic and therapeutic strategies for dengue fever management.

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Association of Allergic Symptoms with Dengue Infection and Severity: A Systematic Review and Meta-analysis

et al. 2019

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Corrigendum to “Does Comorbidity Increase the Risk of Dengue Hemorrhagic Fever and Dengue Shock Syndrome?”

Cited by 15 publications

References 1 publication

Evaluation of clinical and laboratory characteristics of dengue viral infection and risk factors of dengue hemorrhagic fever: a multi-center retrospective analysis

Evaluation of clinical and laboratory characteristics of dengue viral infection and risk factors of dengue hemorrhagic fever: a multi-center retrospective analysis

Alterations in plasma lipid levels as potential predictive markers for clinical prognosis in dengue fever

Association of Allergic Symptoms with Dengue Infection and Severity: A Systematic Review and Meta-analysis

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