Correlative study of tumor budding, mode of invasion and lymphocytic host response with known clinicopathological prognostic factors in oral squamous cell carcinoma

Chaitra, B; Burela, Manasa; Laxmi, Kasula; Inuganti, Renuka Venkata; Tejeswini, Vaddatti

doi:10.4103/jomfp.jomfp_178_20

Cited by 6 publications

(6 citation statements)

References 22 publications

(16 reference statements)

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“…3 Furthermore, one study demonstrated that patients with a WPOI of 5 had a worse 5-year OS rate than those with a WPOI of 1 to 4 (HR, 321.70; 95% CI, 14.31–7228.42; p < 0.001), 20 whereas another reported a 70% mortality rate for patients with a WPOI of 5 compared with 26% for those with a WPOI of 1 to 4 ( p < 0.01). 17 By contrast, another research group found no significant difference in the OS rate between patients with a WPOI of 1 to 4 and those with a WPOI of 5. 10 However, these researchers adjusted their analytical models for the DOI.…”

Section: Discussionmentioning

confidence: 92%

“…Chaitra et al. 17 reported that the mortality rate was 70% in patients with a WPOI of 5 compared with 26% in patients with a WPOI of 0 to 4 ( p < 0.01).…”

Section: Resultsmentioning

confidence: 98%

“…After this thorough screening process, we agreed to include 18 studies involving 3954 patients in our qualitative and quantitative synthesis. 1–5,8,10–12,17–25 The study flow diagram of the selection process is shown in Figure 1.…”

Section: Resultsmentioning

confidence: 99%

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Impact of worst pattern of invasion on prognosis of oral squamous cell carcinoma: a systematic review and meta-analysis

Binmadi,

Mohamed

2023

J Int Med Res

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Objective The relationship between the worst pattern of invasion (WPOI) and the prognosis of oral squamous cell carcinoma (OSCC) remains controversial. This systematic review and meta-analysis was performed to determine the impact of the WPOI on the prognosis of OSCC. Methods Studies from six databases were assessed for quality using the Newcastle–Ottawa Scale, and data were analyzed using Stata software. Results Eighteen studies involving 3954 patients showed that patients with a WPOI of 4 to 5 had significantly worse overall survival, disease-specific survival, and disease-free survival than patients with a WPOI of 1 to 3. Significant associations of the WPOI with locoregional recurrence and mortality were found. Conclusion A higher WPOI was significantly associated with a worse prognosis of OSCC across various outcomes. Incorporating the WPOI into standard histopathological assessments may guide personalized treatments and improve outcomes.

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Section: Discussionmentioning

confidence: 92%

“…Chaitra et al. 17 reported that the mortality rate was 70% in patients with a WPOI of 5 compared with 26% in patients with a WPOI of 0 to 4 ( p < 0.01).…”

Section: Resultsmentioning

confidence: 98%

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Impact of worst pattern of invasion on prognosis of oral squamous cell carcinoma: a systematic review and meta-analysis

Binmadi,

Mohamed

2023

J Int Med Res

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“…These studies have shown a significant association between TB and WPOI with lymph node involvement, worse disease-specific survival, and high rates of recurrence. [ 5 11 16 17 20 21 24 25 26 27 28 ] However, Chaturvedi et al . found a significant association with locoregional recurrence rather than overall survival.…”

Section: Discussionmentioning

confidence: 99%

“…We also found a significant association between the presence of TB with POI ( P < 0.00001) and the grade of the tumor ( P < 0.003216) in similar lines as studied by Chaitra et al . [ 25 ] and Xie et al . [ 17 ] We also found that POI was also significantly associated with the grade of the tumor ( P = 0.009).…”

Section: Discussionmentioning

confidence: 99%

Relevance of Tumor Budding and Pattern of Invasion in Oral Squamous Cell Carcinoma

Deshpande,

Munemane,

Karle

et al. 2024

International Journal of Applied &Amp; Basic Medical Research

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Background: Standard histopathological parameters such as depth of invasion (DOI), lymphovascular invasion (LVI), and perineural invasion (PNI) are known parameters that can correlate with the prognosis and aggressiveness of oral squamous cell carcinomas (OSCCs). Tumor budding (TB) (≤5 tumor cells at infiltrating borders) and pattern of invasion (POI) are emerging histopathological parameters that have shown promising results as reliable risk factors in predicting nodal metastasis in early OSCCs. Aim: The aim of the study was to assess TB and POI in OSCCs. Materials and Methods: A total of 33 surgical resection specimens of OSCC, including buccal mucosa and tongue with neck dissection, were selected. TB and POI along with standard parameters such as grade, DOI, LVI, PNI, lymph node status, and pathological staging were evaluated. These parameters were analyzed in comparison with lymph node involvement and pathological stage of the tumor using the Chi-square and Fischer’s exact test. The SPSS software, v21, was used for statistical analyses. Results: Most of OSCC were moderately differentiated tumors (63.64%). TB was present in 23 cases, in which 69.57% of cases showed low TB (<5 buds), while 30.43% of cases had higher TB (>5 buds). The worst POI (Patterns 4 and 5) was seen in 75.76% of cases. TB, POI, grade, PNI, DOI, and stromal pattern were significantly associated with the pathological stage of the tumor. Conclusion: TB and POI are important and reliable in histopathological parameters in OSCCs.

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Microvascular density analysis and histological parameters of oral cancer progression

et al. 2023

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ObjectivesThis study aimed to investigate the role of blood and lymphatic microvascular density in the progression of oral squamous cell carcinoma (OSCC).Materials and MethodsThe sample was composed of 54 cases of OSCC. The immunoexpression to anti‐alpha‐smooth muscle actin (α‐SMA) and to anti‐endoglin (CD105) was used to determine the microvessel density (MVD); anti‐podoplanin (D2‐40) was used to assess the lymphatic vessel density (LVD); vascular endothelial growth factor (VEGF) was evaluated in malignant cells. The histological differentiation, the worst pattern of invasion (WPOI), tumour thickness and tumour budding (TB) intensity were assessed using haematoxylin–eosin and anti‐pan‐cytokeratin (AE1/AE3). Patients' age and sex, TNM classification and follow‐up time were collected from the medical records.ResultsMVD markers presented a similar pattern of expression in blood vessels. However, only α‐SMA + MVD was significantly higher among women and in tumours ≤4 cm. LVD was lower in tumours with lymph node metastasis. Regarding the histological parameters, high TB intensity was associated with histological differentiation, advanced clinical stage, greater tumour thickness and reduced disease‐free survival. No difference was found in VEGF.ConclusionsThe decrease in OSCC LVD could be related to pathological node involvement, whereas high TB intensity could indicate OSCC progression and worse patient outcomes.

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Correlative study of tumor budding, mode of invasion and lymphocytic host response with known clinicopathological prognostic factors in oral squamous cell carcinoma

Cited by 6 publications

References 22 publications

Impact of worst pattern of invasion on prognosis of oral squamous cell carcinoma: a systematic review and meta-analysis

Impact of worst pattern of invasion on prognosis of oral squamous cell carcinoma: a systematic review and meta-analysis

Relevance of Tumor Budding and Pattern of Invasion in Oral Squamous Cell Carcinoma

Microvascular density analysis and histological parameters of oral cancer progression

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