Correlative Study of Diabetic Retinopathy with HbA1c and
Microalbuminuria

Garg, Pragati; Misra, Smriti; Yadav, Swati; Singh, Luxmi

doi:10.17554/j.issn.2409-5680.2018.04.79

Cited by 13 publications

(17 citation statements)

References 16 publications

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“…Patients with uncontrolled diabetes had higher chances of developing DR (66.61%). Similar findings were reported by Garg Petal, 17 Long Metal 19 and Lind Metal. 34 Zhang R et al 18 reported that when fasting plasma glucose exceeded 7.03 mmol/L and HbA1c exceeded 6.4%, the prevalence of DR increased sharply.…”

Section: Discussionsupporting

confidence: 91%

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Association of HbA1c levels with diabetic retinopathy

Singh

Prasad²,

Kaul³

et al. 2021

IJCEO

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To study the association of HbA1C levels with diabetic retinopathy. A total of 330 diagnosed diabetic subjects of all age groups and genders participated in the study. They were grouped according to presence or absence of diabetic retinopathy. All patients HbA1C levels along with fasting blood glucose levels was obtained. Observations were made to find the association between HbA1C levels and diabetic retinopathy. Mean HbA1c level among diabetic retinopathy subjects (9.50) was higher than subjects without retinopathy (8.49). The difference was found to be statistically significant (p < 0.05). With high HbA1c levels high mean fasting blood glucose levels were associated (R value: 0.5856). This is a moderate positive correlation. As glycosylated haemoglobin (HbA1c) levels increases prevalence of diabetic retinopathy also increases and there is a strong relationship between HbA1c levels and diabetic retinopathy.

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Section: Discussionsupporting

confidence: 91%

“…In a study by Lokesh S et al, 16 majority of the patients (38%) were in the age range 61-70 years. Similar findings were reported by Khalid M et al, 12 Pragati Garg, 17 Zhang R, 18 Long M 19 where majority of the patients were above the age of 50 years.…”

Section: Discussionsupporting

confidence: 88%

Association of HbA1c levels with diabetic retinopathy

Singh

Prasad²,

Kaul³

et al. 2021

IJCEO

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“…Fundus examination findings positive for retinopathy were observed in 198 (44.59%) cases. Thus, prevalence of diabetic retinopathy in type II diabetic cases with microalbuminuria as observed in present study was 44.59% [28] .…”

Section: Observation and Resultssupporting

confidence: 65%

“…In the present study, majority of diabetic retinopathy patients had very mild to moderate non-proliferative diabetic retinopathy (58.58%) followed by severe to very severe non-proliferative diabetic retinopathy (29.29%), Only 24 (12.12%) cases had proliferative diabetic retinopathy. In different cross-Sectional studies, prevalence of different grades of retinopathy have been shown to be of similar order with prevalence of lower grades of retinopathy being higher as compared to higher grades or proliferative retinopathy [5,14,15,16,17,28] .…”

Section: Observation and Resultsmentioning

confidence: 99%

“…A total of 444 diabetic patients with microalbuminuria were enrolled in this study. Majority of patients were females (53.16%) and aged between 41 and 60 years (54.730) [28] . Contrary to the profile of patients in present series, Chung et al [11] (2011) had majority of male patients (54%) with a mean age of 64.9 ± 10.8 years in the study population, thus, showing the patients in their series to be older than in present study.…”

Section: Discussionmentioning

confidence: 99%

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A Correlative Study of Duration of Diabetes Mellitus, Microalbuminuria, Hyperlipidaemia with the Severity of Diabetic Retinopathy

Garg¹,

Mishra²,

Mullick³

2019

International Journal of Ophthalmic Research

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Opaque/hazy ocular media preventing fundus visualization, Coexisting ocular disorders likely to mask the findings of diabetic retinopathy, Patients with presence of any of the confounding factors, like fever, active systemic infections, exercise, high protein intake, accelerated hypertension, congestive heart failure, patients not willing to participate in the study were excluded from the study. RESULTS: 444 subjects of either gender were included in our study, out of which 236 patients were females and the rest were males. Majority of the patients lied in the age group of 41-60 years (54.73%) followed by 61-80 years (29.28%) and 20-40 years (15.09%), while only 4(0.90%) patients were aged > 80 years. A statistically significant association with severity of retinopathy and the age of the patients was observed. Proportion of Group I (No retinopathy) was higher in younger patients i.e. 20-40 (74.6%) and 41-60 (54.3%) as compared to elderly cases i.e. 61-80 (46.2%) and this difference was found to be statistically significant (p < 0.001). Statistically significant association was found between the severity of retinopathy and duration of diabetes (p < 0.001). Proportion of severe to very severe retinopathy and proliferative diabetic retinopathy were higher in higher grade of microalbuminuria (Grade II and Grade III). A statistically significant association between microalbuminuria grade and severity of retinopathy was observed (p < 0.001). Total cholesterol was found to be high (240 mg/dl) in 13.74%patients. Prevalence of retinopathy was 60.7%, in patients having high total cholesterol levels. Proportional difference in severity of retinopathy in patients with different total cholesterol levels was found to be statistically significant (p = 0.002). Trivariate analysis between severity of retinopathy, microalbuminuria and serum cholesterol levels, revealed that in microalbuminuria grade 0, difference in prevalence of retinopathy in patients with different serum cholesterol levels was not found to be statistically significant. CONCLUSION: Duration of diabetes and microalbuminuria have been found to be the independent risk factors for diabetic retinopathy, but serum cholesterol levels did not show an independent role in our study. The findings in present study endorsed the view that microalbuminuria poses a risk for diabetic retinopathy which is affected by duration of diabetes, level of glycemic control and lipid levels.

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Prevalence of retinopathy in newly diagnosed type 2 diabetes mellitus patients and its association with microalbuminuria and HbA1c: A cross sectional study from Rajasthan

Praveena¹,

Kumar²,

RK³

2022

J Med sci Res.

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Background: Diabetes mellitus is a major public health problem with multiple medical complications. Microvascular complications of diabetes including diabetic retinopathy, depend on the duration and severity of hyperglycemia. There is a paucity of data about the relationship among diabetic retinopathy, microalbuminuria and HbA1c in newly diagnosed type 2 diabetes mellitus (T2DM) patients. The study was conducted on the prevalence of diabetic retinopathy and its association with microalbuminuria and HbA1c among newly diagnosed T2DM patients. Material and method: It was a hospital-based, cross-sectional study conducted at a tertiary care hospital in Rajasthan. After obtaining written informed consent, data were collected from 150 newly diagnosed T2DM patients. Data were analysed using SPSS 20.0. Categorical variables were presented as proportion and continuous variables were presented as mean (SD). Chi square test and one way ANOVA tests were used for bivariate analysis. Results: The mean (SD) age of patients was 50.43 (12.73) years. About 52.7% (n=79) patients were male. About 30% (n=45) of newly diagnosed T2DM patients had microalbuminuria. Thirty patients (20%) had diabetic retinopathy (DR). About 8% (n=12) participants had mild DR, 10.7% (n=16) had moderate to severe DR and 1.3 (n=2) % had proliferative DR. Microalbuminuria was found significantly associated with HbA1c (P<0.01). Diabetic retinopathy and its severity were also found significantly associated with HbA1c (P<0.01). Conclusion: In newly diagnosed T2DM patients, HbA1c and microalbuminuria are associated with the presence of retinopathy. If follow up studies support these results, periodic ophthalmologic monitoring may be beneficial for those newly diagnosed with T2DM.

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Correlative Study of Diabetic Retinopathy with HbA1c and Microalbuminuria

Cited by 13 publications

References 16 publications

Association of HbA1c levels with diabetic retinopathy

Association of HbA1c levels with diabetic retinopathy

A Correlative Study of Duration of Diabetes Mellitus, Microalbuminuria, Hyperlipidaemia with the Severity of Diabetic Retinopathy

Prevalence of retinopathy in newly diagnosed type 2 diabetes mellitus patients and its association with microalbuminuria and HbA1c: A cross sectional study from Rajasthan

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