Correlations between selected parameters of nasal cavity in neonates and young infants — computed tomography study

Likus, Wirginia; Gruszczyńska, Katarzyna; Markowski, Jarosław; Machnikowska-Sokołowska, Magdalena; Olczak, Zbigniew; Bajor, Grzegorz; Łos, Marek; Baron, Jan

doi:10.5603/fm.a2015.0128

Cited by 9 publications

(10 citation statements)

References 11 publications

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“…On the other hand, many viruses preferentially, or exclusively replicate in dividing cells; hence, their components are potentially becoming an important source/inspiration in the search of drugs that preferentially target cancer stem cells ( Akbari-Birgani et al, 2016 ; Farahani et al, 2014 ; Jain et al, 2015 ; Jain et al, 2016 ). Beside viral methods, some clinically tested drugs as well as new drugs with preferential toxicity towards cancer stem cells are increasingly becoming available ( Jangamreddy et al, 2013 ; Likus et al, 2016a ; Likus et al, 2016b ; Moghadam et al, 2015 ; Moosavi et al, 2016 ). Such tasks are facilitated by recent progress in methodologies that allows for better detection and monitoring of cancer stem cells ( Cieslar-Pobuda et al, 2016 ; Cieslar-Pobuda et al, 2015 ; Likus et al, 2016b ).…”

Section: Discussionmentioning

confidence: 99%

Structure and properties of slow-resorbing nanofibers obtained by (co-axial) electrospinning as tissue scaffolds in regenerative medicine

Hudecki

Gola

Ghavami

et al. 2017

PeerJ

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With the rapid advancement of regenerative medicine technologies, there is an urgent need for the development of new, cell-friendly techniques for obtaining nanofibers—the raw material for an artificial extracellular matrix production. We investigated the structure and properties of PCL10 nanofibers, PCL5/PCL10 core-shell type nanofibers, as well as PCL5/PCLAg nanofibres prepared by electrospinning. For the production of the fiber variants, a 5–10% solution of polycaprolactone (PCL) (Mw = 70,000–90,000), dissolved in a mixture of formic acid and acetic acid at a ratio of 70:30 m/m was used. In order to obtain fibers containing PCLAg 1% of silver nanoparticles was added. The electrospin was conducted using the above-described solutions at the electrostatic field. The subsequent bio-analysis shows that synthesis of core-shell nanofibers PCL5/PCL10, and the silver-doped variant nanofiber core shell PCL5/PCLAg, by using organic acids as solvents, is a robust technique. Furthermore, the incorporation of silver nanoparticles into PCL5/PCLAg makes such nanofibers toxic to model microbes without compromising its biocompatibility. Nanofibers obtained such way may then be used in regenerative medicine, for the preparation of extracellular scaffolds: (i) for controlled bone regeneration due to the long decay time of the PCL, (ii) as bioscaffolds for generation of other types of artificial tissues, (iii) and as carriers of nanocapsules for local drug delivery. Furthermore, the used solvents are significantly less toxic than the solvents for polycaprolactone currently commonly used in electrospin, like for example chloroform (CHCl3), methanol (CH3OH), dimethylformamide (C3H7NO) or tetrahydrofuran (C4H8O), hence the presented here electrospin technique may allow for the production of multilayer nanofibres more suitable for the use in medical field.

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Section: Discussionmentioning

confidence: 99%

Structure and properties of slow-resorbing nanofibers obtained by (co-axial) electrospinning as tissue scaffolds in regenerative medicine

Hudecki

Gola

Ghavami

et al. 2017

PeerJ

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“…This may impact the ease of maneuverability of instrumentation within the sinonasal cavity and necessitate the use of smaller equipment. The published norms for piriform aperture width at birth, 2 years, and 5 years reveal increasing diameter from 15 to 18 mm to greater than 20 mm, respectively . Prior radioanatomic studies revealed no statistically significant increase in piriform aperture diameter from that of the neonate until 15 to 18 years, but the clinical significance of these small changes is notable.…”

Section: Introductionmentioning

confidence: 88%

The expanded endonasal approach in pediatric skull base surgery: A review

London

Rangel

Walz

2020

Laryngoscope Investig Oto

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Objective: Surgery of the pediatric skull base has multiple unique challenges and has seen recent rapid advances. The objective of this review is to assess key issues in pediatric skull base surgery (SBS), including anatomic limitations, surgical approaches, reconstruction techniques, postoperative care, complications, and outcomes.Data Sources: PubMed literature review.Review Methods: A review of the literature was conducted to assess the challenges, recent advances, and reported outcomes in pediatric SBS.Results: The pediatric skull base presents multiple anatomic challenges, including variable patterns of pneumatization, narrow piriform aperture width, and narrow intercarotid distance at the level of the cavernous sinus but not the superior clivus. These issues may be particularly challenging in patients less than 2 years of age. Endoscopic endonasal approaches in the sagittal and coronal plane have been applied to the pediatric skull base while open approaches may still be necessary in the setting of extensive intracranial or orbital disease, as well as disease lateral to critical neurovascular structures. While the nasoseptal flap was initially called into question for pediatric cases, it has been shown through multiple reports to be a feasible and robust reconstructive option. Complications and outcomes often depend upon the pathology. In children, response to noxious stimuli, ability to avoid Valsalva, and adherence to nasal precautions is variable. The use of lumbar drains is more common in pediatric than adult patients.Conclusion: While the pediatric skull base presents unique challenges, outcomes data support that endoscopic endonasal approaches are a pertinent surgical technique in appropriately selected patients. Level of Evidence: 3aK E Y W O R D S endoscopic endonasal approach, pediatric skull base surgery, skull base reconstruction, surgical outcomes

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“…The pyriform aperture poses the second restriction point for skull base surgeons. Previous radioanatomic studies report a mean pyriform aperture diameter of 15 mm at birth, gradually increasing to 18 mm by age 2 years and exceeding 20 mm by age 5 years [5][6][7]. While these measurements may seem trivial, their clinical significance lies in the nearly doubled cross-sectional area of the aperture, transitioning from 15 mm to 20 mm in diameter [8].…”

Section: Nasal and Pyriform Aperturesmentioning

confidence: 96%

Special Considerations in Pediatric Endoscopic Skull Base Surgery

Valencia-Sanchez,

Kim,

Zhou

et al. 2024

JCM

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Originally pioneered in adults, endoscopic endonasal approaches for skull base pathology are being increasingly applied as a minimally invasive alternative for young children. Intrinsic anatomic differences between these patient populations have sparked discussions on the feasibility, safety, and efficacy of these techniques in pediatric patients. This work aims to serve as a primer for clinicians engaged in the rapidly evolving field of pediatric endoscopic skull base surgery. A succinct overview of relevant embryology, sinonasal anatomy, and diagnostic workup is presented to emphasize key differences and unique technical considerations. Additional discussions regarding select skull base lesions, reconstructive paradigms, potential surgical complications, and postoperative care are also highlighted in the setting of multidisciplinary teams.

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Correlations between selected parameters of nasal cavity in neonates and young infants — computed tomography study

Abstract: Background: Correlations between selected metric parameters of the nasal cavity and nasopharynx in children without atresia may be useful for anticipating probable dimensions of this region in living subjects (Folia Morphol 2016; 75, 3: 334-340)

Cited by 9 publications

References 11 publications

Structure and properties of slow-resorbing nanofibers obtained by (co-axial) electrospinning as tissue scaffolds in regenerative medicine

Structure and properties of slow-resorbing nanofibers obtained by (co-axial) electrospinning as tissue scaffolds in regenerative medicine

The expanded endonasal approach in pediatric skull base surgery: A review

Special Considerations in Pediatric Endoscopic Skull Base Surgery

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