Correlations Between Known Prognostic Markers and Tumor - infiltrating Lymphocytes in Breast Cancer

Zgură, Anca; Galeş, Laurenţia; Hăineală, B.; Brătilă, Elvira; Mehedințu, Claudia; Andreescu, Cristina Veronica; Berceanu, Costin; Petca, Aida; Barac, Ramona; Ionescu, Alec; Anghe, Rodica

doi:10.37358/rc.19.7.7340

Cited by 8 publications

(10 citation statements)

References 6 publications

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“…Recent studies have shown that the therapeutic effect of trastuzumab depends on the acquired and adaptive mechanisms, mediated by immunity. For example, a combination therapy that inhibits the PI3K / AKT pathway for resistance to trastuzumab increases the intratumoral infiltration of T cells, thereby expanding the anti-tumor effect and immune response mediated by CD8 + T cell, thus enhancing the therapeutic effects of the anti-HER2 antibody [19][20].…”

Section: Resultsmentioning

confidence: 99%

Immune Effects of Transtuzumab in HER2 Positive Breast Cancer

Zgură¹,

Galeş²,

Hăineală³

et al. 2019

Rev. Chim.

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The immune system could mediate the antitumor activity of several anticancer treatments. Several chemotherapy compounds, including anthracyclines and oxaliplatin, induce immunogenic cell death that in turn activates the antitumor immune response. Trastuzumab induces antibody-dependant cell-mediated cytotoxicity. On the basis of this background, immune markers have recently been the focus of intense translational research to predict and monitor the efficacy of treatments. Gene expression arrays and immunohistochemistry have assessed immune activation and infiltration by macrophages, natural killer, and T and B lymphocytes. In this paper we present the results of a study that included 22 patients diagnosed with Her2 positive breast cancer undergoing treatment with Transtuzumab.

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Section: Resultsmentioning

confidence: 99%

Immune Effects of Transtuzumab in HER2 Positive Breast Cancer

Zgură¹,

Galeş²,

Hăineală³

et al. 2019

Rev. Chim.

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“…It has been showed that both benign and malignant melanocytic lesions are positive for ERβ, but not for ERα, which seems to be very rarely expressed in the skin [20][21]. In line with this observation, various studies support a role for ERβ in contributing to the better survival rates among women [22,23].…”

Section: Hormones and Melanomamentioning

confidence: 92%

The Evaluation of Estrogen Receptor β as a Potential Prognosis Factor in Melanoma

2020

Rev.Chim.

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Differences across sexes in cutaneous melanoma incidence, metastatic pathways and disease outcome are consistently observed, with women having a significant survival advantage compared with men. This suggests that gender could play a role as a prognostic indicator through sex hormone signaling, but the mechanism is still unclear. This article focuses on available literature data concerning the influence of estrogen receptor beta (ERβ) expression as a host-related biological protective factor for female patients with melanoma. Furthermore, it highlights the potential role of estrogen receptor beta (ERβ) as a prognostic biologic marker in cutaneous melanoma. Keywords: melanoma, sex, hormone receptors, estrogen receptor β

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“…Inhaled administration of corticosteroids is related only to early miscarriage, a correlation with the late miscarriage hasn't been described yet. This reflects that intrauterine exposure to this medication influences the fetal environment, leading to an increased risk of early pregnancy loss [35][36][37].…”

Section: Inhaled Corticosteroidsmentioning

confidence: 99%

The Chemical Pregnancy

Dumitrașcu¹,

Iliescu²,

Petca³

et al. 2019

Rev.Chim.

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The chemical pregnancy is an early pregnancy loss occurring shortly after implantation. 50-75% of all miscarriages are considered to be chemical pregnancies. Although the pregnancy test is positive, the fetus cannot be detected on ultrasounds; it can be asymptomatic or it can have menstrual-like cramping and bleeding. There are numerous risk factors associated with miscarriage, such as: epidemiological, genetic, anatomical, endometrial, endocrine and immune factors, infections, inherited thrombophilia and antiphospholipid syndrome. Many drugs are related with spontaneous miscarriage, significant evidence being found for nonsteroidal anti-inflammatory drugs, inhaled corticosteroids, antidepressant medication, antiepileptic and antihypertensive drugs, the artemisinin-based combination therapy and for the diclofenac/misoprostol combination. Besides the common diseases like asthma, chronic hypertension, chronic kidney disease, thyroid disorders, diabetes mellitus, polycystic ovary syndrome and rheumatoid arthritis, there was also found a higher correlation with the risk of miscarriage for the Zika Virus infection. In conclusion, chemical pregnancy is a type of early pregnancy loss which usually doesn�t need prevention, associated with multiple risk factors.

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Correlations Between Known Prognostic Markers and Tumor - infiltrating Lymphocytes in Breast Cancer

Cited by 8 publications

References 6 publications

Immune Effects of Transtuzumab in HER2 Positive Breast Cancer

Immune Effects of Transtuzumab in HER2 Positive Breast Cancer

The Evaluation of Estrogen Receptor β as a Potential Prognosis Factor in Melanoma

The Chemical Pregnancy

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