Correlations between disease activity, autoimmunity and biological parameters in patients with chronic spontaneous urticaria

Montjoye, Laurence de; Darrigade, Anne‐Sophie; Giménez‐Arnau, Ana; Herman, Anne; Dumoutier, Laure; Baeck, Marie

doi:10.23822/eurannaci.1764-1489.132

Cited by 40 publications

(62 citation statements)

References 34 publications

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“…Ma et al demonstrated that plasma levels of D-dimer were associated with disease activity of ANCA-associated vasculitis [34]. A prospective study conducted on patients with chronic spontaneous urticaria has reported that patients with autoimmune status had higher levels of plasma D-dimer than those without autoimmunity [35]. Weinberg et al reported that there were higher levels of D-dimer in the synovium of patients with RA than that in patients with OA and traumatic joint abnormalities [36].…”

Section: Discussionmentioning

confidence: 99%

Plasma Fibrinogen, D-dimer, and Fibrin Degradation Product as Biomarkers of Rheumatoid Arthritis

et al. 2020

Preprint

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Objective: This study aimed to assess the role of coagulation-related indicators such as plasma ﬁbrinogen (FIB), D-dimer, and fibrin degradation product (FDP) in rheumatoid arthritis (RA) and their association with disease activity.Methods: Data from 105 RA patients and 102 age- and gender- matched healthy controls were collected in the retrospective study. Disease activity score in 28 joints based on C-reactive protein (DAS28-CRP) was used to divide the RA patients into inactive group (DAS28-CRP ≤ 2.7) and active group (DAS28-CRP > 2.7). The association between plasma FIB, D-dimer, and FDP and DAS28-CRP was evaluated by spearman correlation. Receiver operating characteristic (ROC) curve was applied to determine the area under curve (AUC) value. The prognostic value of plasma FIB, D-dimer, and FDP in the RA disease activity was tested by logistical regression analysis.Results: RA patients showed higher FAR levels of plasma FIB, D-dimer, and FDP than the controls (P < 0.01). Plasma FIB, D-dimer, and FDP were also increased in active group of RA patients than those in inactive group (P < 0.001). Spearman analysis showed that plasma FIB, D-dimer, and FDP were positively related with DAS28-CRP (P < 0.001) in RA patients. ROC curve analyses revealed that the AUC of D-dimer was higher than ESR and RF, and that of FDP was higher than RF in RA patients. In addition, the optimal cut-oﬀ value of plasma FIB, D-dimer, and FDP for RA diagnosis was 286 mg/dL, 470 μg/L, and 1.45 mg/L, respectively. Logistical regression analyses showed that D-dimer (odds ratio = 2.862, 95% conﬁdence interval: 1.851-4.426, P < 0.001) was a predictor for RA disease activity.Conclusions: FIB, D-dimer, and FDP were increased in RA patients and positively correlated with the disease activity of RA. D-dimer may act as a novel inﬂammatory parameter for predicting disease activity in RA patients.

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Section: Discussionmentioning

confidence: 99%

Plasma Fibrinogen, D-dimer, and Fibrin Degradation Product as Biomarkers of Rheumatoid Arthritis

et al. 2020

Preprint

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“…Rates of concomitant autoimmune diseases tend to be higher in type IIb [25,[118][119][120][121] Rates of concomitant allergic diseases might be higher in type I [119] Total IgE levels low in type IIb and normal or high in type I [14,25] Basopenia rates might be higher in type IIb [24, 111] 2 Eosinopenia rates tend to be higher in type IIb [122] C-reactive protein levels may be higher in type IIb [25,123] ANA positivity rates may be higher in type IIb [124] Responder rates to sgAHs may be lower in type IIb [122][123][124][125] Responder rates to omalizumab high in type I [28] and low in type IIb [62,122,126] Speed of response to omalizumab slow in type IIb [127] Immunosuppressive therapy can be effective in type IIb [128-134] 3 TPO, thyroperoxidase; TG, thyroglobulin; TF, tissue factor; IL, interleukin; dsDNA, double-stranded DNA; BHRA, basophil histamine release assay; BAT, basophil activation test; ASST, autologous serum skin test; WB, Western blot; ELISA, enzyme-linked immunosorbent assay; CRP, C-reactive protein; ANA, antinuclear antibodies; sgAHs, second-generation antihistamines. 1 Measured by ELISA or radioimmunoassay.…”

Section: Type I and Type Iib Autoimmunity: Emerging Endotypes Of Chromentioning

confidence: 99%

Urticaria: Collegium Internationale Allergologicum (CIA) Update 2020

Maurer

Eyerich

et al. 2020

Int Arch Allergy Immunol

132

141

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“… 17 Mean IgE values in CSU patients vary from 66 to 1,037 IU/mL ( Supplementary Table S1 ), regardless of whether comorbid atopic dermatitis was excluded. 18 19 The highest levels of IgE were found in atopic patients with CSU, 20 CSU with concomitant gastroesophageal reflux disorder, 21 and CSU patients with high interleukin (IL)-33 serum levels, 22 indicating that atopic status and concomitant disorders may influence serum total IgE levels of CSU patients.…”

Section: Are Total Serum Ige Levels Elevated In Csu?mentioning

confidence: 99%

Total IgE as a Marker for Chronic Spontaneous Urticaria

Altrichter

Fok

Jiao

et al. 2021

Allergy Asthma Immunol Res

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Objective: Immunoglobulin E (IgE) and its receptor, FcɛRI, importantly contribute to the pathophysiology of chronic spontaneous urticaria (CSU). Recent findings point to a possible role of total IgE as a marker of CSU disease activity, endotypes, and responses to treatment. The evidence in support of total IgE included in the diagnostic workup of patients with CSU has not yet been reviewed. Methods: Publications were searched via PubMed. The search terms used were "chronic urticaria" and "total IgE." Studies were screened by titles and abstracts, and 141 were used in the review. Results: CSU patients frequently had elevated total IgE serum levels (up to 50%), but normal or very low total IgE levels also occurred. High total IgE may represent high disease activity, longer disease duration, high chance of responding to omalizumab treatment, quick relapse after stopping omalizumab, and lower chance of responding to cyclosporine. Low IgE, in contrast, may suggest Type IIb autoimmune CSU, poor response to treatment with omalizumab and a better chance to benefits from cyclosporine treatment. Furthermore, IgE in different CSU cohorts may have different physicochemical properties that could explain differences in treatment responses to IgE-directed therapies. Conclusion: The results of our review suggest that total IgE is a valuable marker for CSU, and we recommend its assessment in the routine diagnostic workup of CSU patients.

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Correlations between disease activity, autoimmunity and biological parameters in patients with chronic spontaneous urticaria

Cited by 40 publications

References 34 publications

Plasma Fibrinogen, D-dimer, and Fibrin Degradation Product as Biomarkers of Rheumatoid Arthritis

Plasma Fibrinogen, D-dimer, and Fibrin Degradation Product as Biomarkers of Rheumatoid Arthritis

Urticaria: Collegium Internationale Allergologicum (CIA) Update 2020

Total IgE as a Marker for Chronic Spontaneous Urticaria

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