Correlations between cascade impactor analysis and laser diffraction techniques for the determination of the particle size of aerosolised powder formulations

Pilcer, Gabrielle; Vanderbist, Francis; Amighi, Karim

doi:10.1016/j.ijpharm.2008.02.014

Cited by 49 publications

(31 citation statements)

References 25 publications

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“…In such a system, a laser beam crosses the end of the metal throat of an impactor [105][106][107]. The entire assembly is a closed system that allows for a controlled airflow rate in the measurement zone.…”

Section: Particle Sizementioning

confidence: 99%

“…The difference between classical and new laser diffraction systems is the particle dispersion capacity of the two methods. The compressed air values applied in the classical dry dispersion unit allow all of the agglomerates to break down, whereas the air flow generated in DPI systems is much lower and does not permit the deagglomeration of all particles [107]. Different correlations between geometric and aerodynamic size data have already been demonstrated.…”

Section: Particle Sizementioning

confidence: 99%

“…Different correlations between geometric and aerodynamic size data have already been demonstrated. For a flow rate, specific inhalation device and drug formulation, the FPF can be predicted from measurements obtained from the laser diffraction technique [107].…”

Section: Particle Sizementioning

confidence: 99%

See 2 more Smart Citations

Lactose characteristics and the generation of the aerosol

Pilcer¹,

Wauthoz²,

Amighi³

2012

Advanced Drug Delivery Reviews

Self Cite

178

113

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Section: Particle Sizementioning

confidence: 99%

Section: Particle Sizementioning

confidence: 99%

See 1 more Smart Citation

Lactose characteristics and the generation of the aerosol

Pilcer¹,

Wauthoz²,

Amighi³

2012

Advanced Drug Delivery Reviews

Self Cite

178

113

View full text Add to dashboard Cite

“…It is one of the only techniques which provides a particle size distribution expressed in terms of mass (rather than number) of particles in each size range [25][26][27]. This is the most relevant parameter for predicting particle transport [28], and health hazard [29].…”

Section: Cascade Impactormentioning

confidence: 99%

Bench Scale Generation of Smoke Particulates and Hydrocarbons from Burning Polymers

Stec¹,

Rhodes²

2011

Fire Saf. Sci.

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The soot and hydrocarbon generation behaviour from four common polymers has been investigated under different fire conditions using different bench scale apparatuses. While well-ventilated flaming typically has high CO 2 /CO ratios and high combustion efficiency, in under-ventilated flaming, higher yields of the many products of incomplete combustion are generally observed, including carbon monoxide, soot and hydrocarbons.Hydrocarbon and soot production from polyethylene, polystyrene, polyamide and polyvinyl chloride were investigated using the steady state tube furnace (ISO TS 19700) under well-ventilated, small underventilated and large under-ventilated fire conditions; and in the smoke density chamber (ISO 5659-2) under the three standard test conditions; and the results have been compared to published data from the fire propagation apparatus (ASTM E 2058). The steady state tube furnace and the fire propagation apparatus show good agreement, for hydrocarbon and soot yields. Conversely it proved impossible to identify correlations with these tests for the soot and hydrocarbon yields in the smoke density chamber.To investigate the soot generation further, the particle size distribution was determined using a cascade impactor. This showed the predominance of 1-5 μm particulates for all polymers, except PVC, in underventilated conditions, and a smaller yield and a more even particle size distribution for well-ventilated burning. For PVC, no significant difference was observed for different fire conditions, with no clear trend of particle size distribution.

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“…There are many studies confirmed that the most profitable features of laser diffraction are time saving, reproducibility, automatic data recording, and automatic processing. Furthermore, the applicability of laser diffraction technique is evaluated as an alternative for cascade impactor analysis for the in vitro characterization of various types of medical aerosol generators (15,(26)(27)(28)(29)(30)(31). Some commonly used laser diffractometers are the Spraytec laser diffractometer (Malvern Instruments, UK) and the Sympatec HELOS laser diffraction analyzer (Sympatec GmbH, Clausthal-Zellerfeld, Germany) (14).…”

Section: Introductionmentioning

confidence: 99%

Effects of Temperature and Humidity on Laser Diffraction Measurements to Jet Nebulizer and Comparison with NGI

Song

Zhan

et al. 2015

AAPS PharmSciTech

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Abstract. Laser diffraction (LD) and next generation impactor (NGI) are commonly used for the evaluation of inhaled drug formulations. In this study, the effect of temperature and humidity on the assessment of the nebulizer particle size distribution (PSD) by LD was investigated, and the consistency between NGI and LD measurements was evaluated. There was an increase in particle size with higher temperature or lower humidity. The particle population with a diameter less than 1 μm was significant at a temperature of 5°C or at relative humidity >90%; however, the same particle population became undetectable when temperature increased to 39°C or at relative humidity of 30-45%. The results of the NGI and LD measurements of aerosol generated from three types of jet nebulizers were compared. A poor correlation between the NGI and LD measurements was observed for PARI LC (2.2 μm) (R 2 = 0.893) and PARI LC (2.9 μm) (R 2 =0.878), while a relatively good correlation (R 2 =0.977) was observed for the largest particle size nebulizer (PARI TIA (8.6 μm)). We conclude that the ambient environment and the nebulizer have significant impacts on the performance and consistency between these instruments. These factors should be controlled in the evaluation of inhaled aerosol drug formulations when these instruments are used individually or in combination.

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Correlations between cascade impactor analysis and laser diffraction techniques for the determination of the particle size of aerosolised powder formulations

Cited by 49 publications

References 25 publications

Lactose characteristics and the generation of the aerosol

Lactose characteristics and the generation of the aerosol

Bench Scale Generation of Smoke Particulates and Hydrocarbons from Burning Polymers

Effects of Temperature and Humidity on Laser Diffraction Measurements to Jet Nebulizer and Comparison with NGI

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