Correlations among enthesitis, clinical, radiographic and quality of life parameters in patients with ankylosing spondylitis

Abstract

Enthesitis was found to be associated with higher disease activity, higher fatigue, worse functional status and lower disease duration. As enthesitis was correlated with BASDAI, we conclude that enthesitis can reflect the disease activity in patients with AS.

Clinical Enthesitis in a Prospective Longitudinal Psoriatic Arthritis Cohort: Incidence, Prevalence, Characteristics, and Outcome

“…In SpA patients with enthesitis, a significantly higher frequency of tender and swollen joint counts as well as more inflammatory axial symptoms have been found . Studies in ankylosing spondylitis (AS) patients revealed a correlation between enthesitis and higher disease activity (measured by the Bath Ankylosing Spondylitis Disease Activity Index [BASDAI]) .…”

“…Pain is one of the consequences of enthesitis, and the current study demonstrated an association between the presence of enthesitis and higher pain scores. Rezvani et al found a positive correlation between enthesitis to the fourth question in the BASDAI questionnaire (level of discomfort from any areas tender to touch or pressure) that refer to entheseal pain among 421 AS patients. Additional support for this point derives from studies in juvenile patients with enthesitis‐related arthritis (ERA) .…”

Correlation of enthesitis indices with disease activity and function in axial and peripheral spondyloarthritis: a cross-sectional study comparing MASES, SPARCC and LEI

“…The Win Pepi version 11.65 was used to calculate sample size; aiming to yield a 80% power to estimate the correlation of the enthesitis indices with disease activity scores and accepting a 5% margin of error, 109 subjects (55 with axial SpA and 54 with peripheral SpA) were deemed necessary [34]. The mean of the correlation coefficient (0,372) from previous work which studied correlation of MASES and SPARCC with BASDAI in AS was used to estimate the sample size of axial SpA since AS is the prototype of axial SpA [5,8,14,15]. The mean of the correlation coefficients obtained by Healey et al in their work which studied correlation of DAS 28 ESR with MASES and LEI (0.374) was used to estimate the number of subjects with peripheral SpA [16].…”

“…Patients with enthesitis present higher disease activity, disability and incapacity to work, frequently associated with a poorer quality of life [4][5][6][7][8][9]. In Brazilian patients, enthesitis was strongly associated with a more severe clinical picture, including axial as well as peripheral manifestations as well as higher Bath Ankylosing Disease Activity Index (BASDAI) [4,7].…”

“…There are 3 tools considered more feasible and usually employed in daily practice and clinical trials: the Maastricht Ankylosing Spondylitis Enthesitis Score (MASES), the Spondyloarthritis Research Consortium of Canada index (SPARCC), and the Leeds Enthesitis Index (LEI) [14][15][16]. Although there are several studies showing the correlation among one of these 3 indices with clinical variables, no single study compared the correlation among the three instruments and clinical variables in the same population [5,8,9,21].…”