Correlation of ultrasonographic appearance of lesions and cytologic and histologic diagnoses in splenic aspirates from dogs and cats: 32 cases (2002–2005)

Ballegeer, Elizabeth A.; Forrest, Lisa J.; Dickinson, Ryan; Schutten, Melissa M.; Delaney, Fern A.; Young, Karen M.

doi:10.2460/javma.230.5.690

Cited by 93 publications

(113 citation statements)

References 22 publications

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“…Além disso, causa desconforto mínimo ao paciente, permitindo que se realizem múltiplas colheitas e amostragens em série, particularmente interessantes quando surgem resultados inconclusivos ou quando existe suspeita de recidiva da lesão 21 . No homem e no cão cada vez mais há estudos que empregam a PAAF para o diagnóstico deste tipo de neoplasia 4,22,23,24,25 . Nos casos de linfadenomegalia, este exame permite a diferenciação rápida entre processos reacionais benignos e neoplásicos 26 .…”

Section: Introductionunclassified

Classificação citológica dos linfomas caninos

Suzano

Sequeira

Rocha

et al. 2010

Braz. J. Vet. Res. Anim. Sci.

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ResumoOs linfomas estão entre as neoplasias mais frequentes na espécie canina. Do IntroduçãoOs linfomas estão entre as neoplasias mais frequentes na espécie canina 1,2,3,4,5 . Nesta espécie, sua incidência é de seis a trinta casos em cada 100.000 cães/ano, sendo maior que na espécie humana 6,7,8 . Ocorrem mais frequentemente em animais com idade entre 5 e 11 anos 9,10,11 , não havendo predileção por sexo 5,11 . Na espécie canina, esta neoplasia é considerada multifatorial e ainda não foi confirmada a participação de agentes virais ou químicos no seu aparecimento 3,12,13 .Os linfomas não-Hodgkin (LNH) do homem apresentam várias características em comum com os linfomas dos cães, particularmente com relação à epidemiologia, etiologia, clínica, morfologia e fenotipagem. Graças a essas semelhanças, os esquemas para classificação morfológica propostas para os LNH -como as de Kiel e Working Formulation -são utilizadas com sucesso por diversos autores para diagnosticar os linfomas da espécie canina. De acordo com alguns autores as características morfológicas dos LNH do homem servem como base para o estabelecimento do prognóstico e de

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Section: Introductionunclassified

Classificação citológica dos linfomas caninos

Suzano

Sequeira

Rocha

et al. 2010

Braz. J. Vet. Res. Anim. Sci.

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“…Survey studies of splenic diseases in this species have reported a prevalence of splenitis ranging from 0.9% to 8%. 7,20 Among its causes, splenitis was described in only single case reports associated with fungal, 2,5,14,25,34,45,46,52 protozoan, 3,18,29,39 or bacterial 1,2,6,12,17,31,40,42,48 infections.The cases related to fungal infections invariably had poor prognosis. In these dogs, necropsy identified splenomegaly and multiple foci of necrosis, while histology documented pyogranulomatous inflammation, multinucleated giant cells, and, in some cases, fungal hyphae.…”

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confidence: 97%

Splenitis in 33 Dogs

et al. 2016

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Splenitis is uncommonly reported in dogs. Herein, the authors describe its prevalence, clinical findings and outcomes, histologic patterns, and causes. Splenic samples of dogs diagnosed with splenitis between 2005 and 2013 were collected and stained with hematoxylin and eosin, Gram, green-Gram, Giemsa, periodic acid-Schiff, and Ziehl-Neelsen. Samples were processed for polymerase chain reaction (PCR) to detect bacteria, fungi, and protozoa ( Leishmania infantum, Hepatozoon canis). Thirty-three of 660 splenic samples (5%) had splenitis. Clinical findings and outcomes were available in 19 dogs (58%); 49% had weakness, 33% had fever, and 84% survived. The most frequent inflammatory patterns included purulent splenitis (27%), pyogranulomatous splenitis (24%), and neutrophilic perisplenitis (15%). One dog had a putative diagnosis of primary splenitis; in 8 dogs, microorganisms were identified histologically or by PCR in the spleen without obvious comorbidities. Twenty-four dogs (73%) had concurrent diseases; a permissive role in the development of splenitis was suspected in 21 of these cases. Histologic examination identified the cause of splenitis in 10 dogs. Bacteria were identified by PCR in 23 cases, but the bacteria were confirmed histologically in only 6 of these. Leishmania was detected with PCR in 6 dogs. Leishmania was identified in 1 dog and H. canis in another histologically, but both were PCR negative. Fungi were identified in 8 spleens by PCR and in 1 by histology. This study suggests that splenitis is uncommon in dogs and is frequently associated with systemic diseases. Prognosis is favorable in most cases. Identification of bacteria, fungi, and protozoa in the spleens of affected dogs with PCR should be interpreted cautiously, because the findings are not confirmed histologically in many cases.

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“…Although this rare tumour showed divergent phenotypic differentiation in this study, the surgery contributed to prolong survival and there was no evidence of tumour infiltration or metastases during the 9-month follow-up period. Sonographic evidence of multiple nodular splenic changes is often associated with malignancy, but is not specific for any particular disease (Hanson et al 2001;Ballegeer et al 2007). Mesenchymomas represent 4% of all splenic malignancies (Spangler and Kass 1997); however, the relative size and morphological appearance makes it difficult to differentiate malignant mesenchymomas from other mesenchymal tumours (Johnson et al 1989;Spangler et al 1994).…”

Section: Discussionmentioning

confidence: 99%

Splenic malignant mesenchymoma in a dog - immunophenotypic features and clinicopathological ramifications: a case report

Dokic¹,

Pirog²,

Benák³

et al. 2014

Vet. Med. - Czech

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ABSTRACT:A 13-year-old spayed bitch was referred for evaluation of an abdominal distension with a palpable, continuously growing mass. Abdominal ultrasonography revealed a 30 × 20 cm mass directly connected to the spleen. Surgical exploration confirmed the sonographic diagnosis with adhesions to the omentum and the liver. Pathohistological samples revealed well differentiated adipose tissue and variably differentiated collagenous and myxomatous tissue. Immunohistochemically, vimentin and in some regions alpha smooth muscle actin were expressed indicating smooth muscle differentiation. The results support the diagnosis of a malignant mesenchymoma composed of liposarcoma, mixosarcoma and leiomyosarcoma. No local recurrence or metastasis occurred during a nine month follow-up. So far, only two pathological retrospective studies describing the common prevalence and properties of canine splenic malignant mesenchymomas were found in the literature. However, this rare tumor entity has to be considered as a differential diagnosis in cases of large splenic masses.

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Correlation of ultrasonographic appearance of lesions and cytologic and histologic diagnoses in splenic aspirates from dogs and cats: 32 cases (2002–2005)

Cited by 93 publications

References 22 publications

Classificação citológica dos linfomas caninos

Classificação citológica dos linfomas caninos

Splenitis in 33 Dogs

Splenic malignant mesenchymoma in a dog - immunophenotypic features and clinicopathological ramifications: a case report

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