Correlation of the vasoconstriction assay and clinical activity in psoriasis

Comparative therapeutic evaluation of different topicals and narrow band ultraviolet B therapy combined with systemic methotrexate in the treatment of palmoplantar psoriasis

“…[9] They range in potency from very weak class VII agents to super potent class I agents as ranked by the Stoughton-Cornell vasoconstriction classification. [10] A double blind, parallel group, multicenter trial revealed that 0.05% halobetasol propionate ointment is more effective in the treatment of patients with chronic localized psoriasis compared to 0.05% clobetasole propionate ointment (86% versus 70%). [11]…”

Study of reservoir effect of clobetasol propionate cream in an experimental animal model using histamine-induced wheal suppression test

“…[36] However, in our study, we have used histamine-induced wheal suppression test for determining the reservoir effect of a topical steroid. This histamine bioassay of topical steroids has many advantages over other known assay techniques.…”

Remission of Psoriasis with Etidronate Treatment of Underlying Paget’s Disease of Bone

“…Psoriasis skin shows both increased metabolic activity [1] and structural abnor malities in the capillary microcirculation [2]. The importance of these microcirculatory changes is suggested by the observation that when chronic psoriatic plaques are treated, the capillary structures return to normal before the labelling index of the basal cells [2], Furthermore the therapeutic efficacy of topical glucocorticoids in psoria sis correlates well with their vasoconstrictor activity [3].…”