Correlation of the degree of dyspnea with health‐related quality of life, functional abilities, and diffusing capacity for carbon monoxide in patients with systemic sclerosis and active alveolitis: Results from the scleroderma lung study

Khanna, Dinesh; Clements, Philip J.; Fürst, Daniel E.; Chon, Yun; Elashoff, Robert M.; Roth, Michael D.; Sterz, Mildred; Chung, Joannie; Fitzgerald, John; Seibold, James R.; Varga, John; Theodore, Arthur C.; Wigley, Fredrick M.; Silver, Richard M.; Steen, Virginia D.; Mayes, Maureen D.; Connolly, M. Kari; Fessler, Barri J.; Rothfield, Naomi F.; Mubarak, Kamal K.; Molitor, Jerry A.; Tashkin, Donald P.

doi:10.1002/art.20787

Cited by 118 publications

(102 citation statements)

References 22 publications

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“…23,32,33 This would be especially important in the few patients in whom the blind had to be removed because of the intention-to-treat principle, but these comprised only two patients who were unblinded after receiving a year of PLA and then received CYC. The cough score is a subjective measurement, the resolution of which may not be sufficiently sensitive to detect clinically relevant changes in cough frequency or severity.…”

Section: Discussionmentioning

confidence: 99%

“…23 Cough severity was graded on a 0-to-3 scale, and cough frequency and phlegm production were graded on 1-to-3 scales ( Fig 1 ). Health-related quality of life was assessed with two instruments: the Medical Outcomes 36-Item Short-Form Health Survey 24 and the Disability Index of the Health Assessment Questionnaire, a measure of functional status that targets the musculoskeletal system and was designed for patients with SSc.…”

Section: Questionnairesmentioning

confidence: 99%

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Correlation of Cough With Disease Activity and Treatment With Cyclophosphamide in Scleroderma Interstitial Lung Disease

Theodore

Tseng

et al. 2012

Chest

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Nonproductive cough is a characteristic symptom of interstitial lung diseases (ILDs), including scleroderma (SSc). In the Scleroderma Lung Study (SLS), a double-blind, randomized, placebo (PLA)-controlled trial of oral cyclophosphamide (CYC) administered for 1 year followed by an additional year of follow-up without treatment, 1 73% of the 158 study participants complained of cough at the time of enrollment, making it the second-most-common nonRaynaud symptom, exceeded only by dyspnea. After 12 to 18 months of therapy initiation, patients who received CYC showed signifi cant improvement in lung function, skin scores, dyspnea, disability, and various aspects of health-related quality of life, compared with those who received PLA. The benefi cial effects on all parameters except dyspnea were lost at 24 months (1 year after discontinuation of CYC). 2 The pathogenesis of cough in SSc and other ILDs is poorly understood. Cough is mediated through

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Section: Discussionmentioning

confidence: 99%

Section: Questionnairesmentioning

confidence: 99%

Correlation of Cough With Disease Activity and Treatment With Cyclophosphamide in Scleroderma Interstitial Lung Disease

Theodore

Tseng

et al. 2012

Chest

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“…Of the few HRQOL studies performed in persons with SSc to date, all have assessed health status (10,11,31) and none have assessed health values. Our results confirm previous findings that individuals with SSc have poor physical functioning (mean PCS score 36.9) and low-normal mental health (mean MCS score 45.5) (10,11).…”

Section: Discussionmentioning

confidence: 99%

Health values of patients with systemic sclerosis

Khanna¹,

Ahmed²,

Fürst³

et al. 2007

Arthritis & Rheumatism

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“…Patients with SSc are classified according to the extent of skin involvement: limited SSc (lSSc), with no detectable skin involvement; limited cutaneous SSc tients with lung disease (30). However, the relevance of using the 2 aggregate scores, PCS and MCS, in SSc has not been demonstrated.…”

Section: Introductionmentioning

confidence: 99%

Assessing disability and quality of life in systemic sclerosis: Construct validities of the Cochin Hand Function Scale, Health Assessment Questionnaire (HAQ), Systemic Sclerosis HAQ, and Medical Outcomes Study 36‐Item Short Form Health Survey

Rannou¹,

Poiraudeau²,

Bérezné³

et al. 2007

Arthritis & Rheumatism

179

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Objective. To assess the construct validity of the Cochin Hand Function Scale (CHFS) and the relevance of using aggregate scores for the scleroderma Health Assessment Questionnaire (sHAQ) and Medical Outcomes Study 36-Item Short Form Health Survey (SF-36) in systemic sclerosis (SSc). Methods. We evaluated 50 patients with SSc (mean ؎ SD age and disease duration 54 ؎ 12 years and 9 ؎ 8 years, respectively), of which 26 had limited cutaneous SSc (lcSSc) and 23 diffuse SSc (dSSc). Quality of life was assessed by the SF-36, global disability by the Health Assessment Questionnaire (HAQ) and sHAQ, and hand disability by the CHFS. Construct validity was assessed by convergent and divergent validity (Spearman's rank correlation coefficient) and factor analysis. Results. The CHFS had good construct validity and its total score explained 75% of the variance of the HAQ. The HAQ had better construct validity than the aggregate sHAQ and their scores correlated well (r ‫؍‬ 0.88). The aggregate sHAQ was no better than the HAQ in discriminating between lcSSc and dSSc. SF-36 physical and mental components had acceptable convergent and divergent validity. Factor analysis of the 8 subscales extracted 3 factors explaining 72% of the variance, which differed from the a priori stratification with physical and mental subscales extracted in the same factor. Conclusion. In patients with SSc, the CHFS has good construct validity, the HAQ should be preferred over the aggregate sHAQ for assessing physical functioning, and use of SF-36 physical and mental components aggregate scores is questionable.

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Correlation of the degree of dyspnea with health‐related quality of life, functional abilities, and diffusing capacity for carbon monoxide in patients with systemic sclerosis and active alveolitis: Results from the scleroderma lung study

Cited by 118 publications

References 22 publications

Correlation of Cough With Disease Activity and Treatment With Cyclophosphamide in Scleroderma Interstitial Lung Disease

Correlation of Cough With Disease Activity and Treatment With Cyclophosphamide in Scleroderma Interstitial Lung Disease

Health values of patients with systemic sclerosis

Assessing disability and quality of life in systemic sclerosis: Construct validities of the Cochin Hand Function Scale, Health Assessment Questionnaire (HAQ), Systemic Sclerosis HAQ, and Medical Outcomes Study 36‐Item Short Form Health Survey

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