Correlation of serum prostate-specific antigen level in various prostate pathology in elderly men

Khant, Varsha S; Goswami, Hansa; Shah, Pooja Y

doi:10.5455/ijmsph.2017.17072016588

Cited by 8 publications

(12 citation statements)

References 10 publications

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“…PSA levels, DRE, and transurethral USG and biopsy investigations are routinely used tests for diagnosing prostate lesions. 10 17,18 All these studies report contrasting results, which are much different from our study.…”

Section: Discussioncontrasting

confidence: 99%

Association of Serum PSA Levels with Histopathological Pattern of Prostate Lesions

Samad¹,

Fayyaz²,

Siddiqa³

et al. 2019

JIMDC

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Background: Pathological changes that mainly affect prostate gland are prostatitis, benign prostatic hyperplasia (BPH) and cancerous lesions. Digital rectal examination (DRE), Transrectal Ultrasonography (TUS), and prostate specific antigen (PSA) followed by histopathological examination, are routinely used tests for diagnosis of prostate lesions. The aim of the present study is to determine the role of serum PSA levels in differentially diagnosing the different types of prostate lesions.Material and Methods: This retrospective (observational) study was conducted in Ibn-e-Sina Hospital Multan. Data of 2189 patients who were operated from 2007 to 2017 due to prostatic lesions were included in this analysis. Patients with BPH, prostatitis, prostate carcinoma and Prostatic Intraepithelial Neoplasia (PIN) were grouped according to serum PSA levels (ranging from 0 to >100 ng/ml) into five groups. Frequencies and percentages were calculated for different histopathological findings. Association of PSA levels with different histological patterns was determined with chi-square test with P-value < 0.05 taken as significant difference.Results: Mean age of patients was 62.45+10.64 years. On histopathology, BPH was diagnosed in 1676 (76.56%) patients, prostatitis in 133 (6.07%), carcinoma in 378 (17.26%) and PIN in 02 (0.09%) patients, respectively. Serum PSA levels of 4.01-10 ng/ml were found in 1050 (62.64%) BPH patients and in 59 (44.36%) prostatitis patients. Serum PSA levels of 10.01-20 ng/ml were found in only 40 (2.4%) BPH patients, 47 (35.33%) prostatitis patients, 22 (5.82%) carcinoma patients and in 1 (50.0%) PIN patient. Serum PSA levels of 20.01-100 ng/ml were found in 32 (1.9%) BPH patients, 11 (8.27%) prostatitis patients, 302 (79.89%) carcinoma patients, and in 1 (50.0%) PIN patient. Serum PSA levels of >100 ng/ml were absent in patients with BPH and PIN, and present in 1 (0.75%) prostatitis and 54 (14.28%) carcinoma patients.Conclusion: Benign prostatic hyperplasia was the commonest lesion in our patients (76.56%) with serum PSA levels >10 ng/ml reported in all patients with prostate carcinoma and prostatic intraepithelial neoplasia (PIN) patients.

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Section: Discussioncontrasting

confidence: 99%

Association of Serum PSA Levels with Histopathological Pattern of Prostate Lesions

Samad¹,

Fayyaz²,

Siddiqa³

et al. 2019

JIMDC

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“…In present study, 50.86% cases were benign and 49.14% cases were malignant, comparable to 60.91% benign cases and 37.27% malignant cases in the study done by Varsha Khant et al (2017). [6] Another study by Dr. Atchyuta .M et al (2016) [7] had 79.7% benign cases and 20.3% malignant cases. Geographical location and environment may account for this uneven distribution of benign and malignant lesions.…”

Section: Discussionsupporting

confidence: 81%

“…Geographical location and environment may account for this uneven distribution of benign and malignant lesions. The above studies by Varsha Khant et al (2017) [6] and Atchyuta .M et al(2016) [7] included prostatic biopsies as well as prostate www.pacificejournals.com/apalm eISSN: 2349-6983; pISSN: 2394-6466 chips(Transrectal Urethral Resection of Prostate chips), whereas we included only TRUS biopsies. This can also account for more benign cases in these studies.…”

Section: Discussionmentioning

confidence: 99%

Prostate Specific Antigen (PSA) Levels and its Correlation to Prostatic Lesions

Londhe

Shah²

2018

APALM

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Special stain (ZN stain) and immunohistochemistry (HMW-CK, p63 and AMACR) were used in granulomatous prostatitis and suspicious lesions respectively. ABSTRACTBackground: To correlate PSA levels with prostatic lesions and grade of Prostatic adenocarcinoma Methods:The study includes male patients with lower urinary tract complaints, advised to get their PSA levels and Transrectal ultrasound (TRUS) guided prostatic biopsy done. Study design was observational and retrospective. Universal sampling method has been used for selection, during study period May 2015 to September 2016. Ethical clearance has been obtained from Medical Ethical Committee of Saifee Hospital. We received 116 TRUS biopsies in the described time frame. The relevant data for these were collected from the hospital and departmental records.Results: Out of 116 cases, 57 cases were malignant and 59 cases were benign. Fifty-three (93%) of the malignant cases and 54 (91.5%) of the benign cases had PSA levels above 4 ng/ml. Thus, association of PSA level and type of lesion was found to be statistically insignificant (p >0.05). The mean PSA level was 19.67ng/ml in Grade 1 Prostatic adenocarcinoma, 10.84ng/ml in Grade 2 Prostatic adenocarcinoma, 21.07ng/ml in Grade 3 Prostatic adenocarcinoma, 39.06ng/ml in Grade 4 Prostatic adenocarcinoma and 399.26ng/ml in Grade 5 Prostatic adenocarcinoma. Thus, the mean PSA level increased as the grade increased but it was statistically not significant (p>0.05).Conclusion: Serum PSA level as tumor marker has limitations. Thus, histopathological examination is more specific for correct diagnosis in clinically suspicious cases.

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“…Outcome of some studies are similar to our findings of 73.91%. 11,14 In older age group involvement of chronic prostatitis associated with nodular hyperplasia is a common finding. There were 15.21% cases of this type in this series.…”

Section: Discussionmentioning

confidence: 99%

“…Prostate specific antigen assessment released from this gland is helpful in screening and detection of lesion. 11 However, its variability may not be specific for cancer detection as it may be raised in various other disease of prostate. The clinic-pathologic parameters like Gleason grading, imaging finding and molecular markers are combined together to provide better and more accurate prognosis of tumor and ultimately to make proper treatment and management course.…”

Section: Introductionmentioning

confidence: 99%

Spectrum of prostate gland lesions: a clinico-pathologic study in south-western Bihar, India

Kumar

Ahmad

2019

Int J Adv Med

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Background: Prostate gland is an endocrine dependent organ in males and age-related lesions involve it. Inflammation, benign nodular hyperplasia and tumours are the commonest to involve it worldwide. Occasionally some other pathological changes can also involve it. The study was carried out for the first time to know the spectrum and prevalence of prostate lesions which will be of help to the clinicians in this location.Methods: Retrospective study was carried out for a period of four years and out of surgical cases of males which underwent operative procedure, prostate cases were retrieved and in the department of pathology, haematoxylin and eosin stained slides were evaluated and diagnosed.Results: A total of 138 cases were included and five cases were excluded from this series. Benign nodular hyperplasia (73.9%) was the commonest finding followed by chronic prostatitis associated with hyperplasia (15.2%), atypical glandular hyperplasia (2.9%) and prostatic intraepithelial neoplasia (2.1%). Malignant tumours were 5.8% constituting adenocarcinoma prostate as the most common (62.5%). A case of hemangiopericytoma was also diagnosed.Conclusions: Benign nodular hyperplasia of prostate is the most common affliction among males starting at age 45 years. Early consultation and screening will be of immense value. Adenocarcinoma prostate may involve at age around 58 years.

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Correlation of serum prostate-specific antigen level in various prostate pathology in elderly men

Cited by 8 publications

References 10 publications

Association of Serum PSA Levels with Histopathological Pattern of Prostate Lesions

Association of Serum PSA Levels with Histopathological Pattern of Prostate Lesions

Prostate Specific Antigen (PSA) Levels and its Correlation to Prostatic Lesions

Spectrum of prostate gland lesions: a clinico-pathologic study in south-western Bihar, India

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