Correlation of Serum FGF23 and Chronic Kidney Disease‐Mineral and Bone Abnormality Markers With Cardiac Structure Changes in Maintenance Hemodialysis Patients

Zeng, Dewang; Zha, Aiyun; Lei, Ying; Yu, Zongchao; Cao, Rui; Li, Ling; Song, Zhuoheng; Li, Weilong; Li, Yunyi; Li, Haiping; Huang, Shang-Xiao; Dong, Xiangnan; Krämer, Bernhard K.; Hocher, Berthold; Li, Yin; Yun, Chen; Morgera, Stanislao; Guan, Baozhang; Yu, Meng; Liu, Fanna; Hu, Bo; Luan, Shaodong

doi:10.1155/2023/6243771

Cited by 3 publications

(2 citation statements)

References 25 publications

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“…The first presentation of CKD-MBD is mostly characterized by biochemical abnormalities. In advanced stages of the illness, individuals may have bone and muscular pain, weakness, fractures, and even avascular necrosis [5] . CKD patients had a significantly elevated prevalence of bone fractures.…”

Section: ~ 2 ~mentioning

confidence: 99%

Prevalence of mineral bone disorders in chronic kidney disease patients in Gharbia governorate

Rabea,

Okda,

Saad

et al. 2024

Int. J. Adv. Res. Med.

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Background: As kidney function deteriorates, there is a gradual breakdown in the balance of minerals and hormones in the body. The mineral and endocrine functions play a crucial role in regulating of bones. Chronic kidney disease (CKD) -mineral bone disorders (MBD) refer to a wide-ranging clinical condition that arises as a result of CKD, affecting the body's mineral and bone metabolism. The objective of this study was to assess the frequency of mineral bone disorder (MBD) in patients with CKD in Gharbia governorate. Methods: This cross-sectional and comparative study was carried out from January 2018 to December 2019 at Tanta University Hospitals and Gharbia governmental and central hospitals on 1400 patients aged more than 18 years old, both sexes. Patients are categorized into two equal groups: Group 1: (n=700) non-hemodialysis-dependent CKD patients and Group 2: (n=700) hemodialysis-dependent CKD patients. Results: The frequency of elevated bone turnover was substantially greater in the individuals with ESRD compared to those with CKD (42.9% vs 1.4%, p<0.001). Conversely, the occurrence of poor bone turnover was notably greater in the CKD patients compared to the ESRD patients (78.6% vs 35.7%, p<0.001). A strong positive connection was seen between serum PTH levels and age (r = 0.122; p< 0.001), blood urea (r = 0.402; p< 0.001), serum creatinine (r = 0.467; p< 0.001), serum phosphorus (r = 0.549; p< 0.001), and ALP (r = 0.595; p< 0.001). A strong inverse relationship was seen between blood PTH levels and eGFR (r = -0.558; p< 0.001), as well as serum calcium levels (r = -0.646; p< 0.001). A strong correlation was seen between several categories of bone mineral density (BMD) and the features and etiology of CKD (p<0.001). Conclusions: In Gharbia Governorate, BMD is prevalent in CKD. 80% of the patients with nondialyzable CKD and ESRD had low and high bone turnover.

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Section: ~ 2 ~mentioning

confidence: 99%

Prevalence of mineral bone disorders in chronic kidney disease patients in Gharbia governorate

Rabea,

Okda,

Saad

et al. 2024

Int. J. Adv. Res. Med.

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“…Other studies highlighted the role of FGF-23 in predicting the progression of CAC [ 72 , 73 ], also independently from hyperphosphatemia, LVH and cardiac hypertrophy [ 74 ]. It has recently been shown that dialysis patients with higher interleukin-6 (IL-6) values experience greater progression than those with lower values [ 75 ].…”

Section: Prediction Of Cad In Patients With Eskdmentioning

confidence: 99%

Coronary Artery Disease in Patients Undergoing Hemodialysis: A Problem that Sounds the Alarm

Barbuto,

Hu,

Abenavoli

et al. 2024

Rev. Cardiovasc. Med.

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Chronic kidney disease (CKD) is affecting more and more individuals over time. The importance of the increased prevalence is enhanced by the close association with the increased risk of poor individual outcomes such as death, fatal and non-fatal cardiovascular (CV) events and progression to end stage kidney disease (ESKD). ESKD requires replacement treatment such as hemodialysis (HD), a particular and complex context that unfortunately has been rarely considered in observational studies in the last few decades. The current perspective of HD as a bridge to kidney transplant requires greater attention from observational and experimental research both in the prevention and treatment of CV events in ESKD patients. We present a narrative review by performing a literature review to extrapolate the most significant articles exploring the CV risk, in particular coronary artery disease (CAD), in ESKD and evaluating possible innovative diagnostic and therapeutic tools in these patients. The risk of CAD increases linearly when the estimated glomerular filtration rate (eGFR) declines and reached the most significant level in ESKD patients. Several diagnostic techniques have been evaluated to predict CAD in ESKD such as laboratory tests (Troponin-T, N-terminal pro b-type natriuretic peptide, alkaline phosphatase), echocardiography and imaging techniques for vascular calcifications evaluation. Similarly, treatment is based on lifestyle changes, medical therapy and invasive techniques such as coronary artery bypass grafting (CABG) and percutaneous coronary intervention (PCI). Unfortunately in the literature there are no clear indications of the usefulness and validity of biomarkers and possible treatments in ESKD patients. Considering the ESKD weight in terms of prevalence and costs it is necessary to implement clinical research in order to develop prognostic reliable biomarkers for CV and CAD risk prediction, in patients with ESKD. It should be highlighted that HD is a peculiar setting that offers the opportunity to implement research and facilitates patient monitoring by favoring the design of clinical trials.

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Hemodiafiltration with endogenous reinfusion for uremic toxin removal in patients undergoing maintenance hemodialysis: a pilot study

Lu,

Fang,

et al. 2024

Renal Failure

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Correlation of Serum FGF23 and Chronic Kidney Disease‐Mineral and Bone Abnormality Markers With Cardiac Structure Changes in Maintenance Hemodialysis Patients

Cited by 3 publications

References 25 publications

Prevalence of mineral bone disorders in chronic kidney disease patients in Gharbia governorate

Prevalence of mineral bone disorders in chronic kidney disease patients in Gharbia governorate

Coronary Artery Disease in Patients Undergoing Hemodialysis: A Problem that Sounds the Alarm

Hemodiafiltration with endogenous reinfusion for uremic toxin removal in patients undergoing maintenance hemodialysis: a pilot study

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