Hemodialysis-related porphyria cutanea tarda (HRPCT) is characterized by porphyria-like blisters on sun-exposed parts of the face, arms and hands due to elevated porphyrin levels. Conjunctival squamous cell carcinoma (CSCC) is a rare cancer that typically occurs on the sun-damaged ocular surface of elderly male patients. Herein, we report a case of CSCC in a 72-year-old patient who had been on hemodialysis for 8 years, and had been followed up with a diagnosis of HRPCT for 3 years. To our knowledge, this is the first case report documenting an association between HRPCT and CSCC, which may reflect a pathogenetic process connecting them.