Correlation of Osteoporosis and Calcium Urolithiasis in Adult Population

Abstract

Introduction:Scientific studies indicate that there is a correlation between decreased bone mineral density and the age of the patient, especially in post menopausal women.Goal:The aim of our study was to assess the connection between osteoporosis and the age of respondents, based on the DEXA findings in patients with calcium urolithiasis.Material and methods:The study was prospectively and conducted in University Clinical Center Banja Luka, at the Urology Clinic and Clinic of Internal Medicine. In this study the respondents were divided into two groups: experimental group–subjects with calcium urolithiasis and control group without calcium urolithiasis. The study included 240 patients, in both groups of 120 patients who were divided into three age groups: 20-40 years, 40-60 years and more than 60 years. In both groups of respondents was conducted determination of bone mineral density in L2-L4 vertebra lumbar spine and hip by DEXA method.Results:Observing the whole sample of the experimental group, according to age groups it can be noticed that DEXA results are at 72.5% normal, 27.5% below expected value, more in women within older subgroups, 20% show signs of osteopenia and osteoporosis in 7.5 %. Share of patients with osteoporosis is statistically different (p<0.05) only between sub-groups 20-40 years and over 60 years. Although appears absolute difference in the participation of patients with osteopenia by age groups, the differences are not statistically significant (p>0.05). The share of patients with normal DEXA values was significantly lower in the group over 60 years compared to the other two age groups (p<0.05). At age subgroups of the control group, the youngest group of respondents share with normal DEXA finding is 95% and among the oldest group (over 60 years) this share is much lower and is 60%, which represents a statistically significant difference, and confirms the relationship (p<0.01). Normal DEXA findings decreases with increasing years, the share of those who do not have normal findings is higher in the elderly population.Conclusion:Our study has just shown that in adult patients with calcium urolithiasis osteoporosis is more prevalent in older patients and more pronounced in patients with calcium urolithiasis in relation to the population without the same.

Kidney Stone Disease and Osteoporosis: A Mendelian Randomization Study

“…A retrospective study of 57 patients with recurrent kidney stones, as well as 54 controls, also indicated that patients with recurrent kidney stones had signi cantly lower bone mineral density [18]. According to a study that grouped patients with urolithiasis by age, osteoporosis incidence increased with age [19]. Carbone et al 7 present a different perspective.…”

Association of Urolithiasis With Osteoporosis in Postmenopausal Women: Risk Predictors for the Disease

“…New studies by multiple regression show signifi cant impact of age and daily calcium intake on bone mass loss in urolithiasis patients. Signifi cantly reduced bone mass was found in urolithiasis patients compared to control group, and it was more prevalent in older population, especially women in menopause (19).…”

Osteoporosis Complicating Some Inborn or Acquired Diseases

“…20 % of calcium stone formers have osteopenia and 7 % osteoporosis. Although normal DXA declines with increasing age, osteoporosis is more prevalent and more pronounced in older patients (over 60 years of age) with nephrolithiasis (Bijelic et al 2016). On the other hand, Sakhaee et al (2017) did not find any association between urine calcium and BMD in patients with calcium nephrolithiasis in a large group of males and estrogen treated females.…”