Correlation of Optical Intensity on Optical Coherence Tomography and Visual Outcome in Central Retinal Artery Occlusion

Chen, Haoyu; Hu, Xia; Qiu, Zhiqiao; Chen, Weiqi; Chen, Xinjian

doi:10.1097/iae.0000000000001017

Cited by 38 publications

(32 citation statements)

References 25 publications

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“…31 In a later study of 15 patients with CRAO, the same group identified a strong association by Spearman correlation with final BCVA to the optical intensity ratio, a parameter derived by dividing the optical intensity of inner retina by the optical intensity of photoreceptor/RPE layer (r = 0.825, p < 0.001). 32 …”

Section: Ophthalmic Investigationmentioning

confidence: 99%

Central Retinal Artery Occlusion: Acute Management and Treatment

Mehta

Marco

Goldhardt³

et al. 2017

Curr Ophthalmol Rep

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Purpose of Review This review will seek to answer if advances in ophthalmic imaging and evolution of treatment modalities have shed further light on the epidemiology, pathophysiology, diagnosis, and acute management of acute CRAO. Recent Findings Imaging characteristics of acute CRAO have been further characterized with the use of fluorescein angiography, optical coherence tomography (OCT), OCT-angiography, and indocyanine-green angiography. Layer segmentation of OCT imaging has found inner retinal layer hyper-reflectivity to be a common finding in acute CRAO. Non-invasive therapies, fibrinolytic delivery, and surgical interventions for acute CRAO have been further evaluated as potential management tools. Summary A large body of literature reports very inconsistent treatment success with a wide variety of modalities. Currently, there is no clear evidence supporting the use of fibrinolytics in acute CRAO. Large, multicenter, randomized control trials are necessary to elucidate the role of the various acute treatment options in the management of CRAO.

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Section: Ophthalmic Investigationmentioning

confidence: 99%

Central Retinal Artery Occlusion: Acute Management and Treatment

Mehta

Marco

Goldhardt³

et al. 2017

Curr Ophthalmol Rep

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“…An OIR of the inner retina over the RPE calculated from grayscale JPEG images exported from commercial OCT software was found to be associated with a poorer functional outcome in patients with central retinal artery occlusion. 17 Similarly, subretinal fluid OIR obtained by comparing the intensity of a manually segmented region of subretinal fluid with that of the vitreous cavity has been shown to be capable of distinguishing exudation from patients with central serous chorioretinopathy to those with neovascular AMD. 23,24 Browning et al 14 recently used a qualitative analysis and ischemia grading scale to evaluate inner retinal reflectivity in CRVO.…”

Section: Discussionmentioning

confidence: 99%

“…Acute central retinal artery occlusion demonstrates uniform hyperreflectivity of the ganglion cell layer. 17 Paracentral acute middle maculopathy, which is believed to represent focal ischemia at the capillary level, manifests as increased reflectivity at the level of the inner nuclear layer. 18 The degree of reflectivity in the inner retina after acute CRVO varies considerably, but has not been evaluated quantitatively to date as a potential visual prognostic marker.…”

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confidence: 99%

Increased Inner Retinal Layer Reflectivity in Eyes With Acute CRVO Correlates With Worse Visual Outcomes at 12 Months

Mehta

Lavinsky

Gattoussi

et al. 2018

Invest. Ophthalmol. Vis. Sci.

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In acute CRVO, ganglion cell layer changes at 1 month, including increased reflectivity and increased heterogeneity of reflectivity signal as expressed as OIR and OIR variance, were associated with a poorer visual prognosis at 1 year. Technique calibration with larger sample sizes and automated integration into OCT platforms will be necessary to determine if OIR can be a clinically useful prognostic tool.

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“…Previously, we have observed increased optical intensity in retinal inner layers during the acute phase of central retinal artery occlusion, which could be a potential biomarker for retinal ischemia. 30,31 Similarly, the increased optical intensity of inner retinal layers in endophthalmitis eyes suggests that inflammation of retinal vessel results in vascular occlusion, subsequently leading to retinal ischemia, and finally atrophy occurs in the retinal inner layers causing irreversible visual impairment.…”

Section: Discussionmentioning

confidence: 99%

Atrophy of retinal inner layers is associated with poor vision after endophthalmitis: a spectral domain optical coherence tomography study

Chen

et al. 2017

Eye

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PurposeTo investigate the retinal structural changes in endophthalmitis and their association with visual outcome.Patients and methodsForty-five eyes of 45 patients diagnosed with endophthalmitis were included. Spectral domain optical coherence tomography (SD-OCT) was performed after inflammation was controlled. The relationship between SD-OCT features and best-corrected visual acuity (BCVA) at the last follow-up was analyzed.ResultsThe structural changes included inner segment ellipsoid (ISe) disruption (49%), atrophy of retinal inner layers (24%), epimacular membrane (24%), and macular edema (24%). BCVA was worse in patients with ISe disruption (P=0.005) and retinal inner layers' atrophy (P=0.004) compared with those without. There was no significant difference of BCVA between the patients with and without epimacular membrane, or intraretinal cysts. Multivariate regression showed that atrophy of retinal inner layers (b=0.41±0.17, P=0.022) was the only independent factor associated with BCVA.ConclusionAtrophy of retinal inner layers is associated with visual impairment in endophthalmitis, despite successful management.

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Correlation of Optical Intensity on Optical Coherence Tomography and Visual Outcome in Central Retinal Artery Occlusion

Abstract: Optical intensity ratio on OCT is highly correlated with visual prognosis in central retinal artery occlusion. It may be a potential biomarker of retinal ischemia.

Cited by 38 publications

References 25 publications

Central Retinal Artery Occlusion: Acute Management and Treatment

Central Retinal Artery Occlusion: Acute Management and Treatment

Increased Inner Retinal Layer Reflectivity in Eyes With Acute CRVO Correlates With Worse Visual Outcomes at 12 Months

Atrophy of retinal inner layers is associated with poor vision after endophthalmitis: a spectral domain optical coherence tomography study

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