Correlation of narrow band imaging endoscopy and histopathology in the diagnosis of nonerosive reflux disease

Abstract

Background /Aim:Narrow band imaging (NBI) is a novel, innovative high-resolution endoscopic technique, which utilizes spectral narrow band filter for the visualization of mucosal patterns and microvasculature. Nonerosive reflux disease (NERD) is a type of gastroesophageal reflux disease (GERD) and it is characterized by reflux symptoms without mucosal breaks on white light endoscopy (WLE). Biopsies from distal esophagus of GERD patients show group of histologic features such as basal cell hyperplasia, elongation of lamina propria papillae, and inflammatory cells. The present study was undertaken to evaluate diagnostic utility of NBI endoscopy and biopsy study in NERD patients and also to correlate NBI endoscopy findings with histologic features of GERD.Patients and Methods:A total of 71 cases of NERD having symptom score more than 10 and those not having erosion on WLE were recruited prospectively and underwent NBI endoscopic examination. Two mucosal biopsies were taken at 3 cm above the squamocolumnar junction.Results:Histologic features of GERD were seen in 50 (70.4%) out of 71 cases. No significant correlation between NBI endoscopic findings with histologic features of GERD was found.Conclusion:The present study showed that histopathologic evaluation of distal esophageal mucosa has promising diagnostic value over NBI endoscopy in NERD patients. Use of newly introduced NBI technique requires tremendous familiarity for the detection of the cases of NERD, which show histologic features of GERD.

Screening of endoscopic microerosions in non-erosive esophagitis by high-definition digestive endoscopy coupled with narrow-band imaging and microerosions analysis by immunohistochemical, pHmetric and histology

“…It was evidenced that none of the findings verified was significant in relation to the characteristic histological alterations of GERD. The study revealed histological changes compatible with GERD in 70.4% of the patients [36].…”

Enfermedad por reflujo gastroesofágico como factor asociado a asma bronquial en población pediátrica

“…Sin embargo, no se encontró una relación estadísticamente significativa entre esofagitis y asma bronquial. Dicho hallazgo que podría explicarse con el hecho de que puede existir sintomatología de ERGE sin la presencia de hallazgos endoscópicos y que la severidad de estos síntomas tampoco se correlaciona con los hallazgos endoscópicos, como lo señalan los estudios de Zuberi BF et al y Arul P. et al (16,17) . Por otra parte, hay estudios como el de Ashraf K et al que sugieren que, si existe una asociación entre estas variables, por lo que nuestro resultado permanece controversial (18) .…”

GERD-related chronic cough: Possible mechanism, diagnosis and treatment

“…Baseline impedance is highly sensitive in detecting GERC and distinguishing between different phenotypes, with a reported specificity of 95% and a positive predictive value of 96% ( Naik et al, 2019 ). Low baseline impedance has been associated with LES insufficiency, esophageal hypersensitivity, abnormal esophageal acid exposure, typical GERD symptoms, and positive acid perfusion tests ( Woodland et al, 2013 ; Zhong et al, 2013 ; Arul et al, 2015 ; Lottrup et al, 2017 ). The role of MI in GERC needs further investigation.…”