Correlation of Microglial Activation with White Matter Changes in Dementia with Lewy Bodies

Nicastro, Nicolas; Mak, Elijah; Williams, Guy B.; Surendranathan, Ajenthan; Bevan-Jones, William Richard; Passamonti, Luca; Vazquez-Rodriguez, P.; Su, Li; Arnold, Robert; Aigbirhio, Franklin I.; Rowe, James B.

doi:10.1101/599241

Cited by 1 publication

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“…The most prominent changes were seen in the corona radiata, corpus callosum, superior longitudinal fasciculus, sagittal stratum and internal capsule. This is in keeping with some previous region of interest studies [30,31] though others have not found changes in these areas [32]. Previous region of interest studies have also reported decreased FA in regions including the uncinate and inferior occipitofrontal fasciculi in DLB compared with controls [5,32,33].…”

Section: Discussionsupporting

confidence: 91%

Diffusion imaging in dementia with Lewy bodies: Associations with amyloid burden, atrophy, vascular factors and clinical features

Donaghy

Firbank

Petrides

et al. 2020

Parkinsonism & Related Disorders

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White matter disruption in dementia has been linked to a variety of factors including vascular disease and cortical pathology. We aimed to examine the relationship between white matter changes on diffusion tensor imaging (DTI) in DLB and factors including vascular disease, structural atrophy and amyloid burden. MethodsParticipants with DLB (n=29), Alzheimer's disease (AD, n=17) and healthy controls (n=20) had clinical and neuropsychological assessments followed by structural and diffusion tensor 3T MRI and 18 F-Florbetapir PET-CT imaging. Voxelwise statistical analysis of white matter fractional anisotropy (FA) and mean diffusivity (MD) was carried out using Tract-Based Spatial Statistics with family-wise error correction (p<0.05). ResultsDLB and AD groups demonstrated widespread increased MD and decreased FA when compared with controls. There were no differences between the DLB and AD groups.In DLB, increased MD and decreased FA correlated with decreased grey matter and hippocampal volumes as well as vascular disease. There was no correlation with cortical florbetapir SUVR. The relationship between DTI changes and grey matter/hippocampal volumes remained after including Cumulative Illness Rating Scale-Geriatric vascular score as a covariate. ConclusionsWidespread disruption of white matter tracts is present in DLB and is associated with vascular disease, reduced hippocampal volume and reduced grey matter volume, but not with cortical amyloid deposition. The mechanism behind the correlation observed between hippocampal volume and white matter tract disruption should be investigated in future cohorts using tau imaging, as hippocampal atrophy has been shown to correlate with tau deposition in DLB.

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