Correlation of High Sensitivity C-Reactive Protein and Calcific Aortic Valve Disease

Arterial hypertension in degenerative non-severe aortic stenosis

“…In the present study we noticed significantly higher levels of inflammatory markers (WBC and CRP) in severe AS-patients what could be probably an evidence of degenerative AS severity, similar to results of Galante et al [17]. However in some studies no significant relationship between CRP levels and severity of AS was found [18,19] and the theory of inflammation exists in the early stage of evolving AS [3,19]. On the other hand, the studied non severe AS-patients had bigger atherosclerotic burden comparing to opposite group: incorrect serum lipid profile (higher level of triglyceride and cholesterol ratio), higher BMI, creatinine levels similar to other studies [6,20], frequently CAD and previous MI.…”

Validation of Plasma Biomarkers in Degenerative Calcific Aortic Stenosis

“…Homocysteine is a marker associated with endothelial dysfunction, however due to the poor statistical power, the exact role of homocysteine in CAS could not be established (11,12). Osteopontin is of special interest as a biomarker for CAS, since it is the only molecule directly involved in the ectopic calcification phenomenon that occurs in the latter stages of CAS (13,14). Table II.…”

The Inflammatory Infiltrate in Calcific Aortic Stenosis is Characterized by Clonal Expansions of T Cells and is Associated with Elevated Proportions of Circulating Activated and Effector Memory CD8 T Cells

“…The results in those with bicuspid CAS were entirely similar to those found in tricuspid CAS, indicating that this immune response was an intrinsic feature of CAS and not likely to be secondary to immunosenescence. It is possible that the significant elevations of CRP reported in CAS cases (Galante et al 2001, Jeevanantham et al 2007) is a constitutive component of the CD8 T cell activation and differentiation to a memory-effector phenotype, together reflecting the presence of a systemic adaptive immune response. A www.intechopen.com lesser degree of activation and differentiation to the memory effector phenotype was found in the CD4 T cell subset in approximately half of the cases.…”