Correlation of hematological parameters and cycle threshold in ambulatory patients with SARS‐CoV‐2 infection

Abstract

Introduction Former studies have shown that hematologic parameters are affected by the SARS‐CoV‐2 infection which has caused a global health problem. Therefore, this research aims to identify the most frequent symptoms and comorbidities in SARS‐CoV‐2 infected outpatients; besides, to analyze hematological parameters and their correlation with cycle threshold (Ct) values. Methods We analyzed a total of sixty outpatients with SARS‐CoV‐2 infection. They were divided according to sex. Afterward, a questionnaire was carried out to find out their symptoms and comorbidities. Additionally, blood biometry data were correlated with the Ct value, respectively. Results Sixty patients were analyzed; the mean age was 43 years. All patients were from Nayarit, Mexico. The frequency index showed that the main symptoms were headache and anosmia, and the comorbidities were obesity and smoking. The analysis of blood biometry showed a clear increase in red blood cells (RBC) related parameters in women. In both sexes an increase in the number of white blood cells (WBC) was observed. Also, all the hematological alterations correlated with the grade of infection. Conclusion Headache and anosmia are the most common symptoms according to the frequency index, the main comorbidities were obesity and smoking. Also, there is a Ct value correlation with hematological parameters (WBC, mean corpuscular volume, mean corpuscular hemoglobin, hemoglobin); they can be used as a prognostic marker of infection.

Comparative Analysis of Age, Sex, and Viral Load in Outpatients during the Four Waves of SARS-CoV-2 in A Mexican Medium-Sized City

“…The most reliable method for the detection of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is RT-PCR [5]. This technique is expensive and inaccessible to most people; the advances in vaccination have compensated in some way for these deficiencies, since the vaccination of high-risk groups has reduced the mortality rate and viral shedding [47][48][49][50].…”

“…The symptomatology of SARS-CoV-2 is highly variable; however, common symptoms are observed in other infectious diseases. Patients exhibit fever, dry cough, loss of smell and/or taste, gastrointestinal complaints, headache, muscle pain, and chest pain, and in severe cases, respiratory distress and inability to speak or move, or even death [2][3][4][5].…”

SARS-CoV-2 Genomic Surveillance in Nayarit, Mexico (Summer-Winter 2021-2022)

“…Then patients were swabbed (nasopharynx/oropharynx) using two medical grade flocked nylon swabs (iClean ® ), which were placed on the mucosa while gently swirled for a few seconds, then removed while rotating and placed in 2.5 mL of the sterile viral transport medium (VTM). Sterile VTM (pH 7.10) was prepared according to Girón-Pérez et al (16).…”

EN PRENSA. Graphical-mathematical model to estimate CO2 concentration level as an indicator of SARS-CoV-2 transmission. EN PRENSA

“…Además, para evitar incluir en este ensayo a cualquier portador asintomático de SARS-CoV-2, un día antes del ensayo se recogió una muestra de saliva (2 mL) de todos los participantes según el protocolo descrito previamente por Girón-Pérez et al (2021), se analizó el gen E mediante qRT-PCR y la presencia del virus mediante el protocolo adaptado de Berlín (Corman et al, 2020;Girón-Pérez et al,2021). Todos los pacientes fueron debidamente informados, aceptaron el uso de la información con fines científicos y firmaron un consentimiento informado antes de las medidas de los parámetros antropométricos y la recolección de muestras.…”