Correlation of Functional Impairment and Morphological Alterations in Patients With Group 2A Idiopathic Juxtafoveal Retinal Telangiectasia

Abstract

To correlate functional impairment with morphological alterations in patients with group 2A idiopathic juxtafoveal retinal telangiectasia.

High-Resolution Photoreceptor Imaging in Idiopathic Macular Telangiectasia Type 2 Using Adaptive Optics Scanning Laser Ophthalmoscopy

“…This finding is similar to the finding reported by Schmitz-Valckenberg et al 7 that scotomas could be located next to fixation points even if there were no visible angiographic abnormalities. Taken together with these results in previous studies, our findings suggest that dark regions seen on AO-SLO images do not represent neuronal damage secondary to vascular abnormalities, but rather earlier neuronal changes involved in the pathogenesis of MacTel type 2.…”

High-Resolution Photoreceptor Imaging in Idiopathic Macular Telangiectasia Type 2 Using Adaptive Optics Scanning Laser Ophthalmoscopy

“…This finding is similar to the finding reported by Schmitz-Valckenberg et al 7 that scotomas could be located next to fixation points even if there were no visible angiographic abnormalities. Taken together with these results in previous studies, our findings suggest that dark regions seen on AO-SLO images do not represent neuronal damage secondary to vascular abnormalities, but rather earlier neuronal changes involved in the pathogenesis of MacTel type 2.…”

Fundus Autofluorescence in Type 2 Idiopathic Macular Telangiectasia: Correlation with Optical Coherence Tomography and Microperimetry

“…Pigment clumping and RPE hyperplasia in type 2 IMT tends to occur predominantly in the temporal parafoveal region3 while the varied RPE changes seen using FAF in patients with AMD tends to occur throughout the macula without a predilection for any specific area 24 . Although we did not note any significant decrements in retinal sensitivity on MP testing or in central visual acuity in eyes with early disease, it should be noted that others have reported decreased scotopic sensitivity using fine matrix mapping as an early feature of type 2 IMT11…”

Perifoveal Müller Cell Depletion in a Case of Macular Telangiectasia Type 2

“…Since MacTel type 2 patients are known to suffer from reduced retinal sensitivity and visual acuity 16–18 we also studied photoreceptors in our MacTel type 2 specimen. As expected, in the control specimen rods (stained with anti-rhodopsin) were excluded from the fovea but clearly visible in the macula and throughout the periphery whereas cones were concentrated in the fovea (Fig.…”

High-Resolution Photoreceptor Imaging in Idiopathic Macular Telangiectasia Type 2 Using Adaptive Optics Scanning Laser Ophthalmoscopy

“…This finding is similar to the finding reported by Schmitz-Valckenberg et al 7 that scotomas could be located next to fixation points even if there were no visible angiographic abnormalities. Taken together with these results in previous studies, our findings suggest that dark regions seen on AO-SLO images do not represent neuronal damage secondary to vascular abnormalities, but rather earlier neuronal changes involved in the pathogenesis of MacTel type 2.…”

Fundus Autofluorescence in Type 2 Idiopathic Macular Telangiectasia: Correlation with Optical Coherence Tomography and Microperimetry

“…Pigment clumping and RPE hyperplasia in type 2 IMT tends to occur predominantly in the temporal parafoveal region3 while the varied RPE changes seen using FAF in patients with AMD tends to occur throughout the macula without a predilection for any specific area 24 . Although we did not note any significant decrements in retinal sensitivity on MP testing or in central visual acuity in eyes with early disease, it should be noted that others have reported decreased scotopic sensitivity using fine matrix mapping as an early feature of type 2 IMT11…”

Perifoveal Müller Cell Depletion in a Case of Macular Telangiectasia Type 2

“…Since MacTel type 2 patients are known to suffer from reduced retinal sensitivity and visual acuity 16–18 we also studied photoreceptors in our MacTel type 2 specimen. As expected, in the control specimen rods (stained with anti-rhodopsin) were excluded from the fovea but clearly visible in the macula and throughout the periphery whereas cones were concentrated in the fovea (Fig.…”

High-Resolution Photoreceptor Imaging in Idiopathic Macular Telangiectasia Type 2 Using Adaptive Optics Scanning Laser Ophthalmoscopy

“…This finding is similar to the finding reported by Schmitz-Valckenberg et al 7 that scotomas could be located next to fixation points even if there were no visible angiographic abnormalities. Taken together with these results in previous studies, our findings suggest that dark regions seen on AO-SLO images do not represent neuronal damage secondary to vascular abnormalities, but rather earlier neuronal changes involved in the pathogenesis of MacTel type 2.…”

Fundus Autofluorescence in Type 2 Idiopathic Macular Telangiectasia: Correlation with Optical Coherence Tomography and Microperimetry

“…Pigment clumping and RPE hyperplasia in type 2 IMT tends to occur predominantly in the temporal parafoveal region3 while the varied RPE changes seen using FAF in patients with AMD tends to occur throughout the macula without a predilection for any specific area 24 . Although we did not note any significant decrements in retinal sensitivity on MP testing or in central visual acuity in eyes with early disease, it should be noted that others have reported decreased scotopic sensitivity using fine matrix mapping as an early feature of type 2 IMT11…”

Perifoveal Müller Cell Depletion in a Case of Macular Telangiectasia Type 2

“…Since MacTel type 2 patients are known to suffer from reduced retinal sensitivity and visual acuity 16–18 we also studied photoreceptors in our MacTel type 2 specimen. As expected, in the control specimen rods (stained with anti-rhodopsin) were excluded from the fovea but clearly visible in the macula and throughout the periphery whereas cones were concentrated in the fovea (Fig.…”