Correlation of drug response in patients and in the clonogenic assay with solid human tumour xenografts

Murine Models to Evaluate Novel and Conventional Therapeutic Strategies for Cancer

“…Several reports support the use of this model, 46,47 including a clinical response comparison study that used a large panel of xenografts derived from patient biopsies. 8,48 This study observed a correlation with clinical outcome for both tumor resistance (97%) and sensitivity (90%). It was concluded that if primary tumors are used, xenograft models can predict clinical activity similar to the clonogenic assay.…”

Murine Models to Evaluate Novel and Conventional Therapeutic Strategies for Cancer

“…Several reports support the use of this model, 46,47 including a clinical response comparison study that used a large panel of xenografts derived from patient biopsies. 8,48 This study observed a correlation with clinical outcome for both tumor resistance (97%) and sensitivity (90%). It was concluded that if primary tumors are used, xenograft models can predict clinical activity similar to the clonogenic assay.…”

2-benzoxazolyl and 2-benzimidazolyl hydrazones derived from 2-acetylpyridine: A novel class of antitumor agents

“…To obtain more detailed information about the antiproliferative activity of the compounds they were tested in clonogenic assays using human tumor xenografts. An excellent correlation of drug response in clonogenic assays and in patients has been found 24. The antiproliferative effects of the new compounds were tested with human bladder, colorectal, non‐small cell lung, small cell lung, mammary, melanoma, prostate and renal tumor cells.…”

“…The present results show that the novel hydrazones may be good candidates. In colony‐forming assays with human tumor xenografts, which exhibit an excellent correlation with the tumor response in patients,24 high antiproliferative activity in colon carcinoma, small cell lung carcinoma and melanoma cell lines was observed (Fig. 4).…”

Synthesis, Cytotoxicity, and Antitumor Activity of Copper(II) and Iron(II) Complexes of 4N-Azabicyclo[3.2.2]nonane Thiosemicarbazones Derived from Acyl Diazines

“…To obtain more detailed information about the antiproliferative activity, selected compounds were tested in a clonogenic assay using human tumor xenografts. An excellent correlation of drug response in clonogenic assays and in patients has been found . The antiproliferative effects of the new compounds were tested in vitro in four human colorectal, one large cell lung, one small cell lung, two breast, two melanoma, two ovarial, two pancreas, and one renal tumor xenograft models (Table ).…”

“…An excellent correlation of drug response in clonogenic assays and in patients has been found. 21 The antiproliferative effects of the new compounds were tested in vitro in four human colorectal, one large cell lung, one small cell lung, two breast, two melanoma, two ovarial, two pancreas, and one renal tumor xenograft models (Table 2). Also in this assay, the compounds exhibited remarkable antiproliferative activity.…”

Murine Models to Evaluate Novel and Conventional Therapeutic Strategies for Cancer

“…Several reports support the use of this model, 46,47 including a clinical response comparison study that used a large panel of xenografts derived from patient biopsies. 8,48 This study observed a correlation with clinical outcome for both tumor resistance (97%) and sensitivity (90%). It was concluded that if primary tumors are used, xenograft models can predict clinical activity similar to the clonogenic assay.…”

2-benzoxazolyl and 2-benzimidazolyl hydrazones derived from 2-acetylpyridine: A novel class of antitumor agents

“…To obtain more detailed information about the antiproliferative activity of the compounds they were tested in clonogenic assays using human tumor xenografts. An excellent correlation of drug response in clonogenic assays and in patients has been found 24. The antiproliferative effects of the new compounds were tested with human bladder, colorectal, non‐small cell lung, small cell lung, mammary, melanoma, prostate and renal tumor cells.…”

“…The present results show that the novel hydrazones may be good candidates. In colony‐forming assays with human tumor xenografts, which exhibit an excellent correlation with the tumor response in patients,24 high antiproliferative activity in colon carcinoma, small cell lung carcinoma and melanoma cell lines was observed (Fig. 4).…”

Synthesis, Cytotoxicity, and Antitumor Activity of Copper(II) and Iron(II) Complexes of 4N-Azabicyclo[3.2.2]nonane Thiosemicarbazones Derived from Acyl Diazines

“…To obtain more detailed information about the antiproliferative activity, selected compounds were tested in a clonogenic assay using human tumor xenografts. An excellent correlation of drug response in clonogenic assays and in patients has been found . The antiproliferative effects of the new compounds were tested in vitro in four human colorectal, one large cell lung, one small cell lung, two breast, two melanoma, two ovarial, two pancreas, and one renal tumor xenograft models (Table ).…”

“…An excellent correlation of drug response in clonogenic assays and in patients has been found. 21 The antiproliferative effects of the new compounds were tested in vitro in four human colorectal, one large cell lung, one small cell lung, two breast, two melanoma, two ovarial, two pancreas, and one renal tumor xenograft models (Table 2). Also in this assay, the compounds exhibited remarkable antiproliferative activity.…”

Murine Models to Evaluate Novel and Conventional Therapeutic Strategies for Cancer

“…Several reports support the use of this model, 46,47 including a clinical response comparison study that used a large panel of xenografts derived from patient biopsies. 8,48 This study observed a correlation with clinical outcome for both tumor resistance (97%) and sensitivity (90%). It was concluded that if primary tumors are used, xenograft models can predict clinical activity similar to the clonogenic assay.…”

2-benzoxazolyl and 2-benzimidazolyl hydrazones derived from 2-acetylpyridine: A novel class of antitumor agents

“…To obtain more detailed information about the antiproliferative activity of the compounds they were tested in clonogenic assays using human tumor xenografts. An excellent correlation of drug response in clonogenic assays and in patients has been found 24. The antiproliferative effects of the new compounds were tested with human bladder, colorectal, non‐small cell lung, small cell lung, mammary, melanoma, prostate and renal tumor cells.…”

“…The present results show that the novel hydrazones may be good candidates. In colony‐forming assays with human tumor xenografts, which exhibit an excellent correlation with the tumor response in patients,24 high antiproliferative activity in colon carcinoma, small cell lung carcinoma and melanoma cell lines was observed (Fig. 4).…”

Synthesis, Cytotoxicity, and Antitumor Activity of Copper(II) and Iron(II) Complexes of 4N-Azabicyclo[3.2.2]nonane Thiosemicarbazones Derived from Acyl Diazines

“…To obtain more detailed information about the antiproliferative activity, selected compounds were tested in a clonogenic assay using human tumor xenografts. An excellent correlation of drug response in clonogenic assays and in patients has been found . The antiproliferative effects of the new compounds were tested in vitro in four human colorectal, one large cell lung, one small cell lung, two breast, two melanoma, two ovarial, two pancreas, and one renal tumor xenograft models (Table ).…”

“…An excellent correlation of drug response in clonogenic assays and in patients has been found. 21 The antiproliferative effects of the new compounds were tested in vitro in four human colorectal, one large cell lung, one small cell lung, two breast, two melanoma, two ovarial, two pancreas, and one renal tumor xenograft models (Table 2). Also in this assay, the compounds exhibited remarkable antiproliferative activity.…”