Correlation of Boiling Ranges of Some Petroleum Solvents With Irritant Action on Skin

Klauder, Joseph V.

doi:10.1001/archderm.1947.01520080057007

Cited by 23 publications

(4 citation statements)

References 3 publications

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“…Thus no generalized increased skin reactivity to the tests with primary irritants could be demonstrated in the 'eczematous* as compared to the 'non-eczematous' subjects. DISCUSSION Klauder & Brill (1947) estimated the tolerance of the skin by patch testing with a number of solvents. They considered the tests practical for the selection of persons for work in which there was exposure to petroleum solvents.…”

Section: Resultsmentioning

confidence: 99%

Skin reactions to primary irritants and predisposition to eczema

Björnberg

1974

Br J Dermatol

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Section: Resultsmentioning

confidence: 99%

Skin reactions to primary irritants and predisposition to eczema

Björnberg

1974

Br J Dermatol

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“…The altered 'set point' of the triggering mechanism for skin inflammation in response to irritants may explain the persistence of eczema in clinical situations such as allergic contact dermatitis, where eczema persists without apparent significant re-exposure to the offending allergen. This may also be fundamental to the development of persistent dermatitis from mild irritants as past work with lubricants suggests (6). This mechanism surely involves the mononuclear phagocyte system.…”

Section: Chemical Analysismentioning

confidence: 99%

“…The factors which determine the inflammatory response to irritants in humans are not fully elucidated. Trauma alters it (6,14) as does concomitant allergic contact dermatitis (1-3). Common experience links consititutional dermatitis such as dyshidrotic eczema and atopic eczema to a greater propensity to develop irritant contact dermatitis.…”

Section: Chemical Analysismentioning

confidence: 99%

The effect of the guinea pig maximization protocol on the irritant response to deodorized kerosene – the excited skin syndrome^*

Nethercott

Lawrence

1983

Contact Dermatitis

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Deodorized kerosene in a concentration of 50 g/100 g in pet. did not cause cutaneous inflammation in 10 control guinea pigs. The proportion of 19 guinea pigs exhibiting inflammation following exposure to deodorized kerosene in the guinea pig maximization test increased, but the increase was not significant. The response in a group of 40 animals, half exposed to tetraethyleneglycol diacrylate and half to nonylphenol polyethoxylate-6, increased (z = 3.505, p = 0,004). The inflammatory response was related to concentration in both groups of animals which exhibited inflammatory responses to deodorized kerosene. The relevance of this alteration and irritant response to the interpretation of predictive tests in animals for sensitization, routine patch testing and repeated insult contact dermatitis is discussed.

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“…In this category may be facial intolerance of all decorative, self-care and therapeutic agents ('status cosmeticus'). Reduction in irritation threshold was observed in humans with repeated insult contact dermatitis due to lubricating oils (15).…”

Section: Irritabilitymentioning

confidence: 99%

Managing the excited skin syndrome: patch testing hyperirritable skin

Mitchell¹,

Maibach²

1997

Contact Dermatitis

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Inflammation-modulating phenomena (IMPs), humoral and cellular, fluctuate during the course of irritant and allergic contact dermatitis influencing irritability of the skin. The patch test procedure is a biological assay, a titration of responses to IMPs which can produce hyporeactivity or hyperirritability of the skin of patients who have dermatitis (PDs) and a single patch test is a 'snapshot' of the tempo of an evolving process. The excited skin syndrome (ESS) refers to hyperirritability from clinical and patch test dermatitis creating false-positive patch test reactions which are not reproducible when dermatitis and IMPs have subsided. During ESS, the threshold for irritancy decreases and irritant reactions increase. Patch test concentrations should be determined and ESS investigated in PDs having enhanced IMPs, not in 'normal' individuals, and if a patch test result is important to a patient the test should be performed more than once. Variable reproducibility is inherent in the patch test method, but ESS can be managed by appropriate testing and retesting, and search for relevance.

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Correlation of Boiling Ranges of Some Petroleum Solvents With Irritant Action on Skin

Cited by 23 publications

References 3 publications

Skin reactions to primary irritants and predisposition to eczema

Skin reactions to primary irritants and predisposition to eczema

The effect of the guinea pig maximization protocol on the irritant response to deodorized kerosene – the excited skin syndrome^*

Managing the excited skin syndrome: patch testing hyperirritable skin

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Correlation of Boiling Ranges of Some Petroleum Solvents With Irritant Action on Skin

Cited by 23 publications

References 3 publications

Skin reactions to primary irritants and predisposition to eczema

Skin reactions to primary irritants and predisposition to eczema

The effect of the guinea pig maximization protocol on the irritant response to deodorized kerosene – the excited skin syndrome*

Managing the excited skin syndrome: patch testing hyperirritable skin

Contact Info

Product

Resources

About

The effect of the guinea pig maximization protocol on the irritant response to deodorized kerosene – the excited skin syndrome^*