Correlation of adverse effects of cisplatin administration in patients affected by solid tumours: A retrospective evaluation

Astolfi, Laura; Ghiselli, Sara; Guaran, Valeria; Chicca, Milvia; Simoni, Edi; Olivetto, Elena; Lelli, G.; Martini, Alessandro

doi:10.3892/or.2013.2279

Cited by 197 publications

(143 citation statements)

References 44 publications

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“…Chemotherapeutic agents have non-specific cellular effects and can cause diffuse cell death and tissue toxicity. Side effects like nausea, vomiting, neuro and nephrotoxicity and bone marrow suppression are among the most frequent side effects of these type of therapies (4,5).…”

Section: Introductionmentioning

confidence: 99%

The Effects of Frankincense on Oral Squamous Cell Carcinoma Cell Line

Jaafari‐Ashkavandi¹,

Hamedi²,

Assar³

et al. 2017

Int J Cancer Manag

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Background: Cytotoxic effects of Frankincense resin have been shown on some cancer cell lines. Due to its low side effects, this study was designed to evaluate the anticancer properties of water soluble elements of Frankincense oleo-gum-resin on human oral squamous cell carcinoma cell line. Methods:Oleo-gum-resin was macerated in ethanol. After filtration, the water soluble fraction of dried residue was extracted. KB cells were treated with 0, 62.5, 125, 250 and 500 µg/mL concentrations of obtained Frankincense aqueous fractions and with Doxorubicin as positive control. Frankincense induced cell cytotoxicity; apoptosis and proliferation were investigated using WST assay, Annexin V-FITC/PI, and Ki-67 staining, respectively. Data were analyzed using Kruskal-Wallis test by SPSS 17 software.Results: IC50 of 137.21 µg/mL was obtained from Frankincense aqueous fraction after 48 hours. The percentage of apoptotic cells was elevated in a time-and dose-dependent manner. There was no statistical difference in the Ki-67 expression of KB cells, using different concentration of Frankincense aqueous fraction after 24 and 48 hours (P = 0.083). Doxorubicin inhibited cells growth essentially through apoptosis. Conclusions:Frankincense aqueous fractions seem to suppress KB cell growth through the induction of apoptosis and necrosis rather than the inhibition of proliferation and hence might be a potential anticancer agent. Structural analysis and purification of potent components are suggested for determining more definitive results.

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Section: Introductionmentioning

confidence: 99%

The Effects of Frankincense on Oral Squamous Cell Carcinoma Cell Line

Jaafari‐Ashkavandi¹,

Hamedi²,

Assar³

et al. 2017

Int J Cancer Manag

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“…Testing precision HDR with Cas9MAV remains for future work. For therapeutic Cas9 applications, the induction of synthetic dose lethality could be a means to reduce the therapeutic dose and side effects of Cisplatin (27). Furthermore, the well-established NHS/EDC conjugation technique used to fuse nanobody and Cas9 variants of interest, with subsequent purification via gel filtration, brings receptor-mediated Cas9 delivery within the scope of the basic research lab.…”

Section: Resultsmentioning

confidence: 99%

Receptor Mediated Delivery of Cas9-Nanobody Induces Cisplatin Synthetic Dose Sensitivity

Roche

Olesen

Hussain

et al. 2018

Preprint

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26The CRISPR/Cas9 system has shown great potential for precisely editing genomic DNA 27 sequences by introducing site-specific DNA cuts that are subsequently repaired by the cell. 28However, delivery of the CRISPR ribonucleoprotein remains an understudied area and hinders 29 realizing the full potential of the system. We prepared Cas9 ribonucleoprotein complexes 30 chemically conjugated to the 7D12 nanobody and demonstrate receptor-mediated transfection of 31Cas9 into A549 non-small-cell lung cancer cells via binding to the epithelial growth factor receptor 32 for subsequent cell internalization. We further show that transfection with a Cas9 33 ribonucleoprotein targeting the BRCA2 gene results in an enhanced sensitivity to the 34 chemotherapeutic drug Cisplatin, and thereby induces a synthetic dose lethality in A549 cells. 35 36

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“…Nephrotoxicity; diarrhea; vomiting [153] Mild hematologic toxicity; diarrhea; vomiting [44] Unknown Unknown…”

Section: Side Effectsmentioning

confidence: 99%

Recent Considerations in the Application of RAPTA‐C for Cancer Treatment and Perspectives for Its Combination with Immunotherapies

Rausch

Dyson

Nowak-Śliwińska

2019

Advanced Therapeutics

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The organometallic ruthenium(II) [Ru(arene)Cl2PTA] PTA -1,3,5-triaza-7-phosphaadamantane compound, RAPTA-C, represents an innovative anti-cancer therapeutic and a better-tolerated alternative to platinum (Pt)-based chemotherapeutic drugs in the treatment of cancer. RAPTA-C exhibits anti-metastatic, anti-angiogenic, and anti-tumoral activities through protein and histone-deoxyribonucleic acid alterations. In comparison to other ruthenium-based drugs, which have been recently evaluated in clinical trials, RAPTA-C is strikingly competitive, especially when administered in combination with other targeted drugs. In this review, the uniqueness of RAPTA-C as an anti-cancer chemotherapeutic compared to metal-based drugs under clinical evaluation and those approved by the Food and Drug Administration is emphasized; specifically, comparing the application of RAPTA-C to platinum-based drugs, for example, cisplatin and oxaliplatin, as well as to prominent ruthenium-based compounds, such as NAMI-A imidazolium-trans-tetrachloro(dimethylsulfoxide) imidazoleruthenium(III) and trans-[tetrachlorobis (1Hindazole) ruthenate(III)] (KP1019)/(N)KP1339(N)KP1339 -sodium. Additionally, the possible correlation between RAPTA-C and immune response modulation, as well as potential applications of RAPTA-C in combination with immune therapeutic regimens, is highlighted.

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Correlation of adverse effects of cisplatin administration in patients affected by solid tumours: A retrospective evaluation

Cited by 197 publications

References 44 publications

The Effects of Frankincense on Oral Squamous Cell Carcinoma Cell Line

The Effects of Frankincense on Oral Squamous Cell Carcinoma Cell Line

Receptor Mediated Delivery of Cas9-Nanobody Induces Cisplatin Synthetic Dose Sensitivity

Recent Considerations in the Application of RAPTA‐C for Cancer Treatment and Perspectives for Its Combination with Immunotherapies

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