Correlation between the lipophilicity of substituted phenols and their inhibition of the Na+/K+-ATPase of Chinese hamster ovary cells

Identification of organic eluates from four polymer‐based dental filling materials

“…These compounds are volatile enough for detection by GC-MS. All eluates found in this study are of small molecular weight and mainly lipophilic, and therefore expected to interact with cell membranes (43). It has been suggested that accumulation of lipophilic compounds in membranes may evoke toxic reactions (44).…”

“…For this reason most studies on large monomers have been analyzed by (high-pressure liquid chromatography) HPLC (7,35,38). It has been suggested that accumulation of lipophilic compounds in membranes may evoke toxic reactions (44). These compounds are volatile enough for detection by GC-MS. All eluates found in this study are of small molecular weight and mainly lipophilic, and therefore expected to interact with cell membranes (43).…”

Identification of organic eluates from four polymer‐based dental filling materials

“…These compounds are volatile enough for detection by GC-MS. All eluates found in this study are of small molecular weight and mainly lipophilic, and therefore expected to interact with cell membranes (43). It has been suggested that accumulation of lipophilic compounds in membranes may evoke toxic reactions (44).…”

“…For this reason most studies on large monomers have been analyzed by (high-pressure liquid chromatography) HPLC (7,35,38). It has been suggested that accumulation of lipophilic compounds in membranes may evoke toxic reactions (44). These compounds are volatile enough for detection by GC-MS. All eluates found in this study are of small molecular weight and mainly lipophilic, and therefore expected to interact with cell membranes (43).…”

Acetylcholinesterase and ATPase activities in erythrocyte ghosts are not affected by 1,2,4-trichlorobenzene: Implications for toxicity by narcotic chemicals

“…This can be done if the effects are expressed on the basis of the calculated concentration of test chemical in the membrane at equilibrium. Here we make some assumptions in order to calculate, on the basis of the available literature [15,27–30], effective membrane concentrations at which membrane proteins are affected. The exact protocols of the experiments described in Ahlers et al [27] and Cascorbi and Ahlers [28] have been published separately [31,32].…”

Quantitative retention-biological activity relationship study by micellar liquid chromatography

“…It was recognized very early that chromatography offered sig-nificant advantages in measurement speed when it could be used. Several methods have been practiced over the previous 40 years including frontal analysis (FA) (6)(7)(8)(9)(10)(11), frontal analysis by characteristic points (FACP) (12,13), peak-maxima methods (14), elution by characteristic point (ECP) (15)(16)(17)(18)(19), and step-and-pulse (minor disturbance) methods (20)(21)(22)(23)(24). These methods have been reviewed by others (25-27).…”

Identification of organic eluates from four polymer‐based dental filling materials

“…These compounds are volatile enough for detection by GC-MS. All eluates found in this study are of small molecular weight and mainly lipophilic, and therefore expected to interact with cell membranes (43). It has been suggested that accumulation of lipophilic compounds in membranes may evoke toxic reactions (44).…”

“…For this reason most studies on large monomers have been analyzed by (high-pressure liquid chromatography) HPLC (7,35,38). It has been suggested that accumulation of lipophilic compounds in membranes may evoke toxic reactions (44). These compounds are volatile enough for detection by GC-MS. All eluates found in this study are of small molecular weight and mainly lipophilic, and therefore expected to interact with cell membranes (43).…”

Acetylcholinesterase and ATPase activities in erythrocyte ghosts are not affected by 1,2,4-trichlorobenzene: Implications for toxicity by narcotic chemicals

“…This can be done if the effects are expressed on the basis of the calculated concentration of test chemical in the membrane at equilibrium. Here we make some assumptions in order to calculate, on the basis of the available literature [15,27–30], effective membrane concentrations at which membrane proteins are affected. The exact protocols of the experiments described in Ahlers et al [27] and Cascorbi and Ahlers [28] have been published separately [31,32].…”

Quantitative retention-biological activity relationship study by micellar liquid chromatography

“…It was recognized very early that chromatography offered sig-nificant advantages in measurement speed when it could be used. Several methods have been practiced over the previous 40 years including frontal analysis (FA) (6)(7)(8)(9)(10)(11), frontal analysis by characteristic points (FACP) (12,13), peak-maxima methods (14), elution by characteristic point (ECP) (15)(16)(17)(18)(19), and step-and-pulse (minor disturbance) methods (20)(21)(22)(23)(24). These methods have been reviewed by others (25-27).…”

Identification of organic eluates from four polymer‐based dental filling materials

“…These compounds are volatile enough for detection by GC-MS. All eluates found in this study are of small molecular weight and mainly lipophilic, and therefore expected to interact with cell membranes (43). It has been suggested that accumulation of lipophilic compounds in membranes may evoke toxic reactions (44).…”

“…For this reason most studies on large monomers have been analyzed by (high-pressure liquid chromatography) HPLC (7,35,38). It has been suggested that accumulation of lipophilic compounds in membranes may evoke toxic reactions (44). These compounds are volatile enough for detection by GC-MS. All eluates found in this study are of small molecular weight and mainly lipophilic, and therefore expected to interact with cell membranes (43).…”

Acetylcholinesterase and ATPase activities in erythrocyte ghosts are not affected by 1,2,4-trichlorobenzene: Implications for toxicity by narcotic chemicals

“…This can be done if the effects are expressed on the basis of the calculated concentration of test chemical in the membrane at equilibrium. Here we make some assumptions in order to calculate, on the basis of the available literature [15,27–30], effective membrane concentrations at which membrane proteins are affected. The exact protocols of the experiments described in Ahlers et al [27] and Cascorbi and Ahlers [28] have been published separately [31,32].…”

Quantitative retention-biological activity relationship study by micellar liquid chromatography

“…It was recognized very early that chromatography offered sig-nificant advantages in measurement speed when it could be used. Several methods have been practiced over the previous 40 years including frontal analysis (FA) (6)(7)(8)(9)(10)(11), frontal analysis by characteristic points (FACP) (12,13), peak-maxima methods (14), elution by characteristic point (ECP) (15)(16)(17)(18)(19), and step-and-pulse (minor disturbance) methods (20)(21)(22)(23)(24). These methods have been reviewed by others (25-27).…”