2016
DOI: 10.1590/0103-8478cr20151062 View full text |Buy / Rent full text
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Abstract: Cardiotoxicity induced by doroxubicin generates systolic disfunction and myocardial remodeling with presence of myofibroblasts. These cells are thought to be attracted to the injured heart to avoid the development of congestive

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“…In agreement with Gava et al . [32] , the present work showed the only cells expressed α-SMA in the myocardium of control group were vascular smooth muscle cells. However two weeks AZ treatment induced significant increase in α-SMA immunostained elongated cells among the cardiomyocytes indicated intense proliferation of myofibroblasts.…”
Section: Discussionsupporting
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“…In agreement with Gava et al . [32] , the present work showed the only cells expressed α-SMA in the myocardium of control group were vascular smooth muscle cells. However two weeks AZ treatment induced significant increase in α-SMA immunostained elongated cells among the cardiomyocytes indicated intense proliferation of myofibroblasts.…”
Section: Discussionsupporting
“…Under pathological conditions, these fibroblasts are transformed into myofibroblasts which are responsible for excessive production of fibronectin and collagen resulted in myocardial fibrosis. Since myofibroblasts exhibited characteristics of fibroblasts and smooth muscle cells, their presence in the myocardium can be assessed by immunohistochemical detection of alpha smooth muscle actin (α-SMA) [32] .…”
Section: Discussionmentioning