Correlation between Survival and Tumour Characteristics in Patients with Chondrosarcoma

Kamal, Achmad Fauzi; Husodo, Kurniadi; Prabowo, Yogi; Hutagalung, Errol Untung

doi:10.1177/230949901502300323

Cited by 14 publications

(16 citation statements)

References 17 publications

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“…Similarly, p73 expression was found to be an early event in human oral carcinogenesis, and patients with epithelial dysplasia positive for p73 had malignant transformation and developed squamous cell carcinoma by their 2-year follow-up (27). In agreement with these reports, our data showed a correlation between p73 methylation and CS histological grade, which is classified based on cellularity, atypia, and pleomorphism (28,29). In particular, there was significantly lower p73 methylation in grade 1 CS compared to that of grade 2 and grade 3, thereby indicating an association between CS transformation/differentiation and p73 methylationregulated protein expression.…”

Section: Discussionsupporting

confidence: 89%

Aberration of p73 Promoter Methylation in Chondrosarcoma

Liu

Garbutt

Hornicek

et al. 2017

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Section: Discussionsupporting

confidence: 89%

Aberration of p73 Promoter Methylation in Chondrosarcoma

Liu

Garbutt

Hornicek

et al. 2017

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“…Many studies reported that the tumor size was associated with better survival of chondrosarcoma patients 21, 27. Kamal et al 7 found that tumor size was not correlated with survival and Bindiganavile et al 22 revealed that tumor volume (in mL) was not a predictor in chondrosarcoma. In our cohort, tumor size > 10 cm was an independent predictor of both OS and CSS.…”

Section: Discussionmentioning

confidence: 99%

“…The 5-year survival rate for chondrosarcoma is 75.2%, which is much higher than that of osteosarcoma and Ewing sarcoma 3. Tumor size, grade, stage, local recurrence, metastasis at presentation, systemic treatment, and radiotherapy are all associated with the prognosis of chondrosarcoma 4-7. Patients with chondrosarcoma and metastasis often have a poor prognosis 8, 9.…”

Section: Introductionmentioning

confidence: 99%

Predictors of the survival of patients with chondrosarcoma of bone and metastatic disease at diagnosis

Wang¹,

Chen²,

Chen³

et al. 2019

J. Cancer

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Purpose : Chondrosarcoma with metastatic disease has a very poor prognosis. However, the prognosis and potential prognostic factors of patients with primary chondrosarcoma of bone and metastasis at presentation have not been documented because of its rarity. Therefore, we examined the prognosis of this special cohort and identify possible prognostic factors. Methods : The Surveillance, Epidemiology, and End Results (SEER) program database was used to identify patients with primary chondrosarcoma of bone and metastatic disease at diagnosis from 2000 to 2013. The prognostic analysis was performed using the Kaplan-Meier method and a Cox proportional hazards regression model. Results : The SEER database contained 264 cases. The overall survival (OS) and cancer-survival specific (CSS) rates of the entire group at 5 years were 28.4% and 31.2%, respectively. The median OS and CSS were 14.0 ± 2.5 and 17.0 ± 2.6 months, respectively. Multivariate analysis revealed that low tumor grade, surgical treatment, tumor size < 10 cm, and first primary tumor were associated with improved OS. Tumor grade, tumor size, and surgery were independent predictors of CSS. Radiation therapy had no effect on either OS or CSS. Conclusion : Among patients with primary chondrosarcoma of bone and metastasis at presentation, low tumor grade, surgical treatment, tumor size < 10 cm, and first primary tumor predict prolonged survival.

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“…According to literature, proton therapy could have been a primary option, but the patient refused to move far away from his residency. CS are still considered fairly radioresistant tumors and, according to literature, CS require doses greater than 60 Gy to achieve local control after incomplete resection [ 6 ]. Even if hypofractionated, RT is not the standard in HN district, we chose a hypofractionated schedule to obtain a higher EQD2 taking into account the biological resistance of CS; moreover, a slight hypofractionation was reported also by other authors in the literature [ 3 ].…”

Section: Discussionmentioning

confidence: 99%

Management of Nasal Septum Chondrosarcoma Occurring in Elderly: A Case Report

Belgioia¹,

Vaccara²,

Bacigalupo³

et al. 2017

Cureus

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Chondrosarcomas (CS) are tumors affecting mainly pelvis, long bones and ribs in middle aged people; involvement of head and neck is rare and nasal septum location is exceptional. We report the follow-up of an 85-year-old patient suffering from head and neck CS. Magnetic resonance imaging (MRI) showed a mass originating from nasal septum. The patient underwent to debulking surgery and adjuvant hypofractionated radiotherapy with excellent tolerability and no evidence of recurrence after 16 months. Hypofractionated radiotherapy delivered with advanced technique (helical tomotherapy) allowed to deliver high doses radiation in elderly patients with limited toxicity.

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Correlation between Survival and Tumour Characteristics in Patients with Chondrosarcoma

Abstract: The survival rate was lower in patients with higher Evan grading, metastasis, or local recurrence.

Cited by 14 publications

References 17 publications

Aberration of p73 Promoter Methylation in Chondrosarcoma

Aberration of p73 Promoter Methylation in Chondrosarcoma

Predictors of the survival of patients with chondrosarcoma of bone and metastatic disease at diagnosis

Management of Nasal Septum Chondrosarcoma Occurring in Elderly: A Case Report

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