Correlation between serum transforming growth factor β1, interleukin‑6 and neonatal respiratory distress syndrome

Abstract

Trend and correlation of transforming growth factor β1 (TGF-β1) and interleukin-6 (IL-6) in serum of children with neonatal respiratory distress syndrome (NRDS) were investigated. A total of 75 NRDS children born in the Xiangyang Central Hospital from July 2015 to August 2017 were analyzed retrospectively. A total of 45 NRDS premature infants who received pulmonary surfactant (PS) within 12 h after birth were treated as PS group, 30 who did not receive PS treatment as non-PS group, and 32 premature infants without NRDS in the same period were selected as control group. Serum levels of TGF-β1 and IL-6 were detected by enzyme linked immunosorbent assay (ELISA) at various time points after birth and their correlation was analyzed. The expression level of TGF-β1 in serum of children in PS group was significantly higher than that in control group on days 1 and 3 after birth (P<0.05). The expression level of TGF-β1 in non-PS group increased continuously with the increase of number of days and was significantly higher than that in control group on days 1, 3 and 7 after birth (P<0.05), and significantly higher than that in PS group on days 3 and 7 after birth (P<0.05). The analysis of the correlation between the severity of the disease and the expression levels of TGF-β1 and IL-6 showed that the expression levels were elevated with the increase of the disease severity. The expression levels of TGF-β1 and IL-6 were positively correlated with severity of the disease (r=0.7509, P<0.05; r=0.8056, P<0.05). The expression levels of TGF-β1 and IL-6 in PS and non-PS groups were positively correlated (r=0.9042, P<0.05; r=0.8905, P<0.05). The results showed that serum TGF-β1 and IL-6 were elevated in NRDS children, and there was a positive correlation between them.

Lung Ultrasound in the Evaluation of Neonatal Respiratory Distress Syndrome

“…NRDS arises in approximately 7% of all neonates and is a leading cause of death in preterm neonates (<37 gestation weeks). 18,19 Thus, close imaging monitoring and instant treatment of NRDS is urgently needed. Currently, a variety of imaging techniques and modalities have been introduced, including chest radiology, computed tomography (CT), fluoroscopy, MR imaging, nuclear medicine, and ultrasound.…”

“…NRDS arises in approximately 7% of all neonates and is a leading cause of death in preterm neonates (<37 gestation weeks) 18,19 . Thus, close imaging monitoring and instant treatment of NRDS is urgently needed.…”

Neonatal Respiratory Distress Syndrome: Things to Consider and Ways to Manage

“…Transforming growth factor β1 (TGF-β1) is a cytokine, which has the responsibility for regulating and differentiating different cell lines [20,21]. These studies have marked the role of TGF-β1 in development of various acute and chronic lung injuries and concluded that this factor can be used as a diagnostic and prognostic one [22]. The same role has been considered for interleukin-6, which is a glycoprotein secreted mostly from T cells and mononuclear macrophages causing inflammatory reactions [23,24].…”